Welcome to the Open Access System!
OpenAccess@IKU is the Academic Open Access System of Istanbul Kultur University. It was established in June 2014 to digitally store and open access the academic outputs of Istanbul Kultur University in international standards. OpenAccess@IKU includes academic outputs such as articles, presentations, thesis, books, book chapters, reports produced within the body of Istanbul Kultur University.
Recent Submissions
Investigation the Role of miR-506 in Metformin-Induced Cell Death Mechanism in MCF-7 and MDA-MB-231 Breast Cancer Cells
(Manisa Celal Bayar Üniversitesi Fen Bilimleri Enstitüsü, 2024) RENCÜZOĞULLARI, ÖZGE; QAYOUMI, SURAYA
Micro RNAs (miRNA) play a role in basic cellular processes such as cell growth, development, cell cycle and apoptosis by affecting gene expression. Abnormal regulation or changes in expression of miRNAs can be observed in many diseases, especially cancer. Therefore, miRNAs are also being investigated as potential therapeutic targets. It has been suggested that miR-506 may be expressed at low levels in various types of cancer and this may contribute to cancer development. In this study, the effect of miR-506 on the sensitivity of breast cancer cells to metformin was evaluated in terms of its effect on cell survival and apoptotic mechanism. Metformin caused a dose-dependent decrease in cell viability and induced loss of mitochondrial membrane potential in MCF-7 cells while MDA-MB-231 cells were more resistant. The colony formation and migration potential of both cell lines with increased miR-506 expression were significantly suppressed after metformin treatment. Additionally, apoptotic cell death triggered by metformin was induced in both cell lines when miR-506 expression was increased. In conclusion, miR-506 acts as a tumor suppressor in MCF-7 and MDA-MB-231 cells and increases their sensitivity to metformin, indicating the potential of miR-506 to be an important therapeutic target in future studies.
Çocukluk Çağı Travmaları ile Suça Yönelik Tutumlar Arasındaki İlişkide Psikopatolojik Belirtilerin Paralel Çoklu Aracı Rollerinin İncelenmesi
(Galenos Yayınevi, 2024) ERBAY, AYHAN
Amaç: Çocukluk çağı travmaları ile suça yönelik tutumlar arasındaki ilişkide psikopatolojik belirtilerin aracı bir etkiye sahip olup olmadığının analiz edilmesi amaçlanmıştır. Yöntem: Belirtilen amaca ulaşabilmek adına ilişkisel tarama modelinden hareket edilmiş, uygunda örnekleme tekniğiyle Ocak 2023-Ocak 2024 tarihlerini kapsayan bu çalışmaya 18 yaşından büyük toplamda 391 kişi çevrimiçi ortamda katılım sağlamıştır. Çocukluk çağı travmaları ile suça yönelik tutumlar arasındaki ilişkide psikopatolojik belirtiler paralel çoklu aracılık rolü analizi ile incelenmiştir. Bulgular: Çocukluk çağı travmalarının suça yönelik tutumlar üzerinden doğrudan bir etki yaratmadığı gözlenmiştir. Benzer şekilde çocukluk çağı travmalarının kontrol edildiği ve psikopatolojik belirtilerin suça yönelik tutumlar üzerindeki etkileri incelendiğinde hiçbir psikopatolojik belirtinin doğrudan şiddete yönelik tutumlar üzerinde etkiye sahip olmadığı ancak kişilerarası duyarlık ve düşmanlık belirtilerinin dolaylı olarak ilişkiyi güçlendirme olasılığına sahip olduğu belirlenmiştir. Sonuç: Suça yönelik tutumlarda bireysel özellikler veya deneyimlenen travmaların tetiklediği bir mekanizmadan öte içinde yaşanılan ailenin, mahallenin ve toplumun bireye etkilerinin bir sonucu olarak ortaya çıktığı psikopatolojik özellikler veya geçmiş dönemki travmaların ise suça yönelimi ancak toplumsal şartlar uygunsa tetiklediği sonucuna ulaşılmıştır.
IoT-Based Fire Detection: A Comparative Study of Machine Learning Techniques
(Niğde Ömer Halisdemir Üniversitesi, 2024) AYRANCI, AHMET AYTUĞ; Erkmen, Burcu
Fires that cannot be detected quickly become uncontrollable. The fires that start to spread uncontrollably pose a significant danger to humans and natural life. Especially in public and crowded areas, fires can lead to possible loss of life and massive property damage. Because of this, it is necessary to detect fires as accurately and quickly as possible. Smoke detectors used with Internet of Things (IoT) technology can exchange data with each other. In this study, data collected from two different types of IoT-based smoke detectors were processed using machine learning algorithms. The k-Nearest Neighbor (k-NN), Multilayer Perceptron (MLP), Radial Basis Function (RBF) Network, Naïve Bayes (NB), Decision Tree (DT), Random Forest (RF), and Logistic Model Tree (LMT) algorithms were used. The data obtained from the smoke detectors were processed using machine learning algorithms to create a highly successful model design. The aim of the study is to design an artificial intelligence-based system that enables the early detection of fires occurring both indoors and outdoors.
Analysis of Instagram Content of the United Nations World Tourism Organization (UN Tourism)
(Gaziantep Üniversitesi Sosyal Bilimler Enstitüsü, 2024) Hazarhun, Eda; Bülbül, Serdar; ARSLAN, PELİN FATMA TUNA; Çetinsöz, Burçin Cevdet
The aim of this study is to discover what kind of posts are shared on the official Instagram page of the World Tourism Organization and the general information (number of followers, followed, number of posts, etc.) of the account. For this purpose, 213 photos and texts shared on the official Instagram account of the World Tourism Organization between 1 January 2023 and 1 January 2024 (one year) were subjected to content analysis. As a result of the content analysis; 12 main themes were identified: "celebrations", "country promotions", "tourism statistics", "tourism reports", "guidelines", "declaration", "tourism programs and strategies", "important days", "announcements", "news", "tourism types" and "tourism ambassadors". According to these themes, it has been determined that the World Tourism Organization used particular importance to strategies for ensuring both environmental and cultural sustainability in tourism, innovation and digitalization practices in tourism, global climate change and the development of tourism education. In addition, the World Tourism Organization focuses on the development of alternative tourism types such as "sustainable tourism", "gastronomy tourism", "responsible tourism", "rural tourism", "mountain tourism", "greener tourism", "event tourism", "marine tourism", "indigenous tourism", "sport tourism" and "accessible tourism", which enable tourism to spread to twelve months in destinations, reduce environmental destruction, protect local cultural values and transfer them to future generations and provide tourists with different experiences. This study contributes to the enrichment of the relevant literature by revealing the tourism strategies and policies that the World Tourism Organization has recently focused on and the alternative tourism types that have become a trend.
BİRCAN, N. GÖZDE
Dr. Öğr. Üyesi
