Welcome to IKU Academic Digital Archive System
OpenAccess@IKU is Istanbul Kultur University's Academic Digital Archive System, established in June 2014 to digitally store and provide open access to academic and artistic outputs in line with international standards and intellectual property rights. The system includes various outputs such as articles, presentations, theses, books, book chapters, reports, encyclopedias, and works of art produced by the university's faculty members and students.
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Recent Submissions
ŞENGÜN, NEZİHE
Dr. Öğr. Üyesi
Alterations in Biomarkers Associated with Cardiovascular Health and Obesity with Short-Term Lifestyle Changes in Overweight Women: The Role of Exercise and Diet
(MDPI, 2024) Pala, Ragip; Cinar, Vedat; Akbulut, Taner; Larion, Alin; Padulo, Johnny; Russo, Luca; Migliaccio, Gian Mario; ŞENGÜN, NEZİHE
Background and Objectives: In this study, the effects of an eight-week exercise and nutrition program on blood lipids, glucose, insulin, insulin resistance (HOMA-IR), leptin, ghrelin, irisin, malondialdehyde (MDA), and Growth Differentiation Factor 15 (GDF15) in overweight women were investigated. Materials and Methods: A total of 48 women volunteers participated in this study. The participants were randomly divided into four groups: control (C), exercise (E), nutrition (N), exercise + nutrition (E + N). While no intervention was applied to group C, the other groups participated in the predetermined programs for 8 weeks. At the beginning and end of this study, body composition was measured and blood samples were taken. Results: It was determined that the body composition components, lipid profile indicators, insulin, glucose, insulin resistance, leptin, ghrelin, irisin, and MDA parameters examined in this study showed positive changes in the intervention groups. Group E had a greater effect on body muscle percentage, MDA, and irisin levels, while group N had a greater effect on blood lipids and ghrelin levels. Conclusions: As a result, it is thought that lifestyle changes are important to improve cardiovascular health and combat obesity, and that maintaining a healthy diet together with exercise may be more effective.
A Fast and Responsive Turn-On Fluorescent Probe Based on a Quinone Conjugated Alkoxy Derivative for Biothiols and a Cellular Imaging Study
(Tubitak Scientific & Technological Research Council Turkey, 2024) Nemetova, Ulviyye; Onem, Ayse Nur; Er, Alev; Celik, Sefa; Ozel, Aysen E.; AKYÜZ, SEVİM; Ozyurek, Mustafa; Ayla, Sibel Sahinler
The detection of intracellular biothiols (cysteine, N-acetyl cysteine, and glutathione) with high selectivity and sensitivity is important to reveal biological functions. In this study, a 2-(2-methoxy-4-methylphenoxy)-3-chloro-5,8-dihydroxynaphthalene-1,4dione (DDN-O) compound (3) was newly synthesized and used as a fluorogenic probe (detector molecule) in the fluorometric method for the rapid, highly selective, and sensitive determination of biothiols. The intensity values (lambda ex = 260 nm, lambda em = 620 nm) of the product were measured by adding biothiols to the reaction medium at varying concentrations and the glutathione equivalent thiol content values of each biothiol were calculated. Using compound 3, glutathione as the reference biothiol was detected in the linear concentration range of 10-70 mu M and the LOD value was found to be 0.11 mu M. Biothiol detection with structurally simple compound 3 was performed at the cellular level within 1 min and the probe was also successfully used in bioimaging with low cytotoxicity. It was concluded that this probe can serve as an alternative to existing fluorescence-based biothiol probes with applications in rapid biothiol detection at the cellular level for biological functions. To evaluate the molecular structure of 3, conformational analysis was performed using the PM3 semiempirical method. The most stable obtained molecular geometry was then optimized at the DFT/wb97xd/6-311++G(d,p) level of theory. Frontier molecular orbitals (HOMO and LUMO) and molecular electrostatic potential map analyses were performed for the optimized structure. Molecular docking studies demonstrated the interactions of 3 with HAS (1AO6) and FhGST (2FHE) target proteins.
Okul Öncesi Dönemde Çocuğu Olan Ebeveynlerin Duygu Sosyalleştirme Davranışları ve Duygusal İstismar Potansiyelleri Arasındaki İlişkinin İncelenmesi
(Türk Psikologlar Derneği, 2024) Ülker, Ayça; AYDOS, EMİNE HANDE
Erken dönemlerde maruz kalınan olumsuz yaşantıların uzun dönemde yaratabileceği riskler göz önüne alındığında çocuğun psikolojik, fizyolojik ve duygusal gelişiminde ailenin, çocuğun duygularına ve duygusal gereksinimlerine verdiği yanıtların önemli olduğu görülmektedir. Bu bağlamda mevcut araştırma, ebeveynlerin duygu sosyalleştirme yaklaşımlarının çocuklarını duygusal açıdan istismar etme potansiyelleri üzerindeki yordayıcı etkisinin araştırılmasını amaçlamaktadır. Araştırmanın örneklemi, okul öncesi dönemde çocuğa sahip 206 ebeveynden oluşmaktadır. Çocukların Olumsuz Duyguları ile Başa Çıkma Ölçeği ve 3-6 Yaş Çocuğa Sahip Ebeveynlere Yönelik Duygusal İstismar Potansiyeli Ölçeği aracılığıyla toplanan verilere regresyon analizi uygulanmıştır. Sonuçlar, ebeveynlerin küçümseyici duygu sosyalleştirme tepkilerinin duygusal istismara neden olan davranış potansiyellerini yordadığını ve destekleyici duygu sosyalleştirme tepkilerinin bir arada, duygusal istismara ilişkin önleyici davranışları yordadığını ortaya koymuştur. Bulgular, duygusal istismarı önleyici ve duygu sosyalleştirme davranışlarını destekleyici etkili ebeveynlik müdahaleleri bağlamında tartışılmıştır.
Quasi-Cauchy Sequences on Asymmetric Metric Spaces
(Univ Nis, Fac Sci Math, 2024) DAĞCI, FİKRİYE İNCE; Çakallı, Hüseyin
In recent years, quasi-Cauchy sequences have been studied by many authors in the real line and in metric spaces. In this paper, we investigate the concepts of quasi Cauchyness of sequences, ward compactness and ward continuity in asymmetric metric spaces. We prove that forward totally boundedness coincides with upward compactness, backward totally boundedness coincides with downward compactness, an upward continuous function on a subset E of an asymmetric metric space X to an asymmetric metric space Y is forward continuous under the condition that forward convergence implies backward convergence on X. We also prove some other interesting theorems.