Welcome to IKU Academic Digital Archive System
OpenAccess@IKU is Istanbul Kultur University's Academic Digital Archive System, established in June 2014 to digitally store and provide open access to academic and artistic outputs in line with international standards and intellectual property rights. The system includes various outputs such as articles, presentations, theses, books, book chapters, reports, encyclopedias, and works of art produced by the university's faculty members and students.
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Recent Submissions
Evaluation of the Relationship Between Nomophobia and Anxiety Level in Young People: An Example From Turkey
(Taylor & Francis Ltd., 2025) KIVANÇ, MERAL MADENOĞLU; Yılmaz, Ülkü; ÇETİN, AYKE NİSA; SABA, EMRE ESER
With the development of communication technology, smartphones have started to fulfill many functions. Frequently used smartphones can cause health problems. Nomophobia is one of these disorders and is known as the fear of being away from cell phones. In this study, it was aimed to examine the relationship between nomophobia and anxiety levels of health sciences faculty students.The study was conducted with 383 students (in the departments of nursing, nutrition and dietetics, physiotherapy and rehabilitation) in the faculty of health sciences of a foundation university between November 2022 and June 2023. The study data were collected by face-to-face questionnaire method. 'Descriptive Data Form', 'Uskudar Nomophobia Scale' and 'Anxiety Rating Scale' were used to collect data. SPSS 24 statistical program was used in the analysis of the study. When the smartphone usage characteristics of the participants were evaluated, it was found that 42.6% of them were anxious when the battery ran out, 44.1% of them sometimes thought that the smartphone affected their academic success, 39.9% of them sometimes delayed eating and sleeping, 50.9% of them thought that the smartphone had physical, psychological and social harms, 46% of them sometimes thought that they were dependent on the smartphone. As the level of nomophobia increases, the anxiety level and sub-dimension scores of individuals increase. When the relationship between nomophobia level and anxiety level was evaluated; it was determined that the level of impairment in functionality, overuse, inability to communicate, and anxiety level of individuals increased as the level of nomophobia increased.
Ethical Decision-Making and Artificial Intelligence in Nursing Education: An Integrative Review
(Sage Publishing, 2025) Şengül, Tuba; Sarıköse, Seda; GÜL, ASİYE
The integration of artificial intelligence technologies is transforming healthcare and nursing education, offering significant benefits for patient care and professional development. However, as their use grows, it is crucial to address the ethical implications to ensure that fundamental principles like justice and integrity are maintained in both clinical and educational settings. The aim of this integrative review is to explore the ethical challenges, risks, and future perspectives of integrating artificial intelligence into nursing education. It examines how these tools influence ethical decision-making processes, identifies critical barriers, and proposes strategies for ethical implementation. Following an integrative review methodology, 184 articles were identified, with 124 remaining after duplicate removal. Fifteen peer-reviewed studies analyzed. The methodological quality of the included studies was assessed using appropriate Joanna Briggs Institute Critical Appraisal Checklists based on study design. Searches were conducted in the PubMed, Cochrane Library, MEDLINE (Ovid), Scopus, Web of Science, CINAHL, and ScienceDirect databases from 2014 to September 2024. Data was analysed using constant comparative analysis. The review is registered in the PROSPERO database (CRD42024609440). Guided by Rest's Four-Component Model of Moral Behavior, the synthesis was organized under four components. Moral Sensitivity included themes such as ethical and psychosocial effects, data privacy, equity in access, and cultural sensitivity. Moral Judgment covered ethical reasoning skills, AI accuracy, bias, and academic integrity. Moral Motivation addressed over-reliance on AI and the need for ethical frameworks. Moral Character highlighted educator roles and research priorities for ethical AI use. Artificial intelligence offers transformative opportunities for nursing education, but also presents significant ethical challenges. To ensure its responsible integration, nursing curricula must adopt clear ethical frameworks, equip educators with the skills to guide students and address disparities in access.
Computational Insights Into the Mechanism of Action of Bleomycin as Anticancer and Antibacterial Agent-Via Molecular Docking and Molecular Dynamics
(Wiley, 2025) Er, Alev; Çelik, Sefa; Özel, Ayşen E.; AKYÜZ, SEVİM
Bleomycin (BLM) is the first-line clinical antibiotic used in the treatment of cancer. It inhibits DNA metabolism and is used in conjunction with other anticancer medications to treat various kinds of malignant tumors. This work focuses on examining more fully the bioactivity of BLM as both anticancer and antibacterial agents. Due to the structure-function relationship, the conformational study of the molecule was carried out first, and its potential conformations were identified. Afterwards, using the energy minimization feature of the YASARA structure program, the obtained lowest energy conformation of the molecule and the receptor taken from the protein databank (ligand-free) were optimized. BLM was subjected to molecular docking tests with two antibiotic-binding proteins (PDB IDs: 1ewj and 2zw7) to determine its action mechanism as a TN5 transposon inhibitor. Moreover, its binding affinities towards thymidylate kinase (TMK) (PDB ID: 4qgg) Escherichia coli DNA gyrase B (PDB ID: 6f86) were also evaluated to reveal its antibacterial potential. Additionally, ligand-receptor interactions were assessed via molecular dynamics (MD) process to confirm the stability of BLM docked into antibiotic binding protein (1ewj), TMK (4qgg) and E. coli DNA gyrase B (6f86) within 500 ns (for 1ewj and 6f86) or 200 ns of time (for 4qgg). Molecular mechanics/Poisson-Boltzmann Surface Area methods (MM/PBSA) were used to compute the binding energies through MD simulations. Dynamics cross correlation matrices (DCCM) analysis and principal component analysis (PCA) on the MD data were performed. Results have cleared the mechanism of action of BLM having anticancer and antibacterial properties.
Non-Normative Childhood in Heteronormative Order
(Wiley, 2025) Çelebi, Gizem; YAĞAN, SEVCAN
This study examines the childhood experiences of LGBT+ adults who were born and raised in Turkey and spent their childhood and adolescence in Turkey within the framework of family, friendship, education, life, and social spheres. The research group consists of 11 participants aged between 18 and 30, 10 of whom are still living in Turkey and 1 of whom moved abroad in adulthood. The participants were selected by snowball sampling method. The research was conducted based on a phenomenological design, which is a qualitative research method. One-to-one in-depth interviews were conducted with each participant. The findings reveal that the participants were exposed to gender norms in their family, friends, educational, and social environments and that this significantly affected their self-discovery processes from an early age. It was determined that the 'coming out' processes and social acceptance of the participants spread over a long period of time. The research highlights the urgent need for structural reforms to protect the rights of LGBT+ children and increase social acceptance.
Single-Crystal Polarized Raman Spectra of 6-Bromopyridine-2-Carbaldehyde
(Wiley, 2025) Brito, Anna Luiza B.; Nogueira, Bernardo A.; ILDIZ, GÜLCE ÖĞRÜÇ; Tommasini, Matteo; FAUSTO, RUI
The room temperature (RT) single-crystal polarized Raman spectra of 6-bromopyridine-2-carbaldehyde (BPCA) have been obtained and interpreted based on fully periodic DFT calculations for the P21/a (No. 14; monoclinic) crystal of the compound. The calculations, performed with the CRYSTAL software employing the Becke three parameters Lee, Yang, and Parr (B3LYP) functional and the polarization-consistent triple-zeta valence plus polarization basis set (pob-TZVP), were able to reproduce very well the experimental data, thus allowing a detailed assignment of the Raman active Ag and Bg modes to individual bands. The isotropic non-polarized Raman spectrum of BPCA was also calculated and shown to agree very well with the corresponding experimental Raman spectrum. Finally, the RT infrared spectrum of BPCA was also revisited in light of the performed periodic calculations, improving on previously reported interpretation based on extrapolation of the interpretation of the spectra obtained for the isolated molecule of the compound to the crystalline phase. In this crystalline system, intermolecular interactions exert only a minor influence on the intramolecular vibrational potential. As such, this study also serves as a benchmark for the employed computational approach, demonstrating its ability to capture the effects of both crystallographic periodicity and symmetry on the polarization features of vibrational spectra.