(İstanbul Kültür Üniversitesi, 2009) Palavan-Ünsal, Narçin; ARISAN, ELİF DAMLA
Mitochondria is a gatekeeper of cell death with
dual function in survival and death decision.
Mitochondria is also an important center for
reactive oxgen species (ROS) production within
most mammalian cells. The bulk of mitochondrial
ROS generation can occur at relatively high rates
compared to cytosolic ROS production and is
primarily determined by metabolic conditions.
This event contributes to mitochondrial damage
in a range of pathologies and is also important in
redox signalling from the organelle to the rest of
the cell. Mitochondria targetting strategies in the
therapeutical options are promising to increase
the ROS generation to induce the apoptosis in
cancer cells. Identification of molecular basis of
therapeutic potential of mitochondrial ROS
generation may provide more successful
therapeutic tools in cancer therapy.
