Meslek Yüksekokulları / Vocational Schools

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    Effect of Environment in Increasing Sustainable Competitiveness at Tourism Destination
    (Peter Lang AG, 2020) Ertuğral, Suna Muğan; TEKELİ, HACER NEYİR; Arslan, Sezgi Gedik
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    Evaluation of the Effects of Blockchain Technology Characteristics on SCOR Model Supply Chain Performance Measurement Attributes Using an Integrated Fuzzy MCDM Methodology
    (Taylor & Francis Ltd., 2023) Çıkmak, Sinan; Kantoğlu, Barış; KIRBAÇ, GÖKHAN
    This research aims to investigate and identify the effects of blockchain technology (BT) characteristics on SCOR supply chain (SC) performance measurement attributes. To achieve this, initially, the importance weights of blockchain characteristics (BC) in the context of the SC are determined by using the Interval Type-2 Fuzzy AHP. Furthermore, in order to rank Supply Chain Operation Reference (SCOR) model SC performance measurement attributes, the Interval Type-2 Fuzzy TOPSIS method is used. As for the conclusion, this research signifies that decentralised, security, and immutability are among the top three in terms of importance weights for SC while the consensus is ranked last and as for BC, SCOR model SC performance measurement attributes are ranked as reliability, asset management efficiency, responsiveness, cost, and agility. This study and its outcomes may serve organisations that are striving to boost their SC performance by applying BT.
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    Shedding Light Into the Biological Activity of Aminopterin, Via Molecular Structural, Docking, and Molecular Dynamics Analyses
    (Taylor & Francis Inc., 2023) Çelik, Sefa; YILMAZ, GÖZDE; AKYÜZ, SEVİM; Özel, Ayşen E.
    In this study, the structural and anticancer properties of aminopterin, as well as its antiviral characteristics, were elucidated. The preferred conformations of the title molecule were investigated with semiempirical AM1 method, and the obtained the lowest energy conformer was then optimized by using density functional (DFT/B3LYP) method with 6-311++G(d,p) as basis set. The vibrational frequencies of the optimized structure were calculated by the same level of theory and were compared with the experimental values. The vibrational assignments were performed based on the computed potential energy distribution (PED) of the vibrational modes. The molecular electrostatic potential (MEP) and frontier molecular orbitals (HOMO, LUMO) analyses were carried out for the optimized structure and the chemical reactivity has been scrutinized. To enlighten the biological activity of aminopterin as anticancer and anti-COVID-19 agents, aminopterin was docked into DNA, & alpha;(IIB)& beta;(3) and & alpha;(5)& beta;(1)integrins, human dihydrofolate reductase, main protease (M-pro) of SARS-CoV-2 and SARS-CoV-2/ACE2 complex receptor. The binding mechanisms of aminopterin with the receptors were clarified. The molecular docking results revealed the strong interaction of the aminopterin with DNA (-8.2 kcal/mol), & alpha;(IIB)& beta;(3) and & alpha;(5)& beta;(1) integrins (-9.0 and -10.8 kcal/mol, respectively), human dihydrofolate reductase (-9.7 kcal/mol), M-pro of SARS-CoV-2 (-6.7 kcal/mol), and SARS-CoV-2/ACE2 complex receptor (-8.1 kcal/mol). Moreover, after molecular docking calculations, top-scoring ligand-receptor complexes of the aminopterin with SARS-CoV-2 enzymes (6M03 and 6M0J) were subjected to 50 ns all-atom MD simulations to investigate the ligand-receptor interactions in more detail, and to determine the binding free energies accurately. The predicted results indicate that the aminopterin may significantly inhibit SARS-CoV-2 infection. Thus, in this study, as both anticancer and anti-COVID-19 agents, the versatility of the biological activity of aminopterin was shown.
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    Turkey's Economy From Different Perspectives After 1980: The Past, Present and the Future
    (Peter Lang AG, 2020) Yılmaz, Ebru Gül; TEKELİ, HACER NEYİR
    Turkey has a crucial change in terms of economic infrastructure after the decision of opening up the economy at 1980. Following import substituting industrialization strategy ended with an economic crisis at the end of 1970s. With the beginning of 1980s in January a very radical economic program has announced that brought economic liberalization. After economic liberalization each economic dynamic has changed as never going to be the same again especially after opening up the capital account completely at 1989. The aim of this book is to share the academic research outputs and the field experiences on Turkey's economy for the related period with contributors from different backgrounds and different perspectives. The contributors to this book with their both academic and field experience provide a broad scanning understanding of the Turkey's Economy after 1980's and also expand the readers horizon on having a better understanding of expectations for the future. We appreciate them for becoming a team and we sincerely thank each of them for sharing their experience and expertise.