(İstanbul Kültür Üniversitesi, 2007-09) Chandawrkar, Akash; Özdinler, P. Hande
ALS (Amyotrophic lateral sclerosis) is a complex
neurodegenerative disorder that affects
corticospinal motor neurons in the cortex, corticobrainstem
neurons and the spinal motor neurons in
the spinal cord. ALS can develop both due to
genetic or sporatic causes. The genetic causes of
the disease are largerly unknown, but the cellular
interactions between motor neurons and their
environment are beginning to elicudate insights
into the cellular pathogenesis of the disease. Even
though cognition, memory and other brain
functions are left intact in patient, the severed
motor neuron circuitry leaves them paralyzed. To
develop therapeutic approaches in ALS, there is a
growing need to understand each and every
component of the motor neuron circuitry, and their
interaction in detail. In this rewiew, we will
introduce cellular components of the complex
neurocircuitry and discuss their possible
contribution for therapeutic approaches in ALS.
