Scopus İndeksli Yayınlar / Scopus Indexed Publications

Permanent URI for this collectionhttps://hdl.handle.net/11413/6358

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Now showing 1 - 12 of 12

Open Access
Biochemical and Proteomic Analyses in Drought-Tolerant Wheat Mutants Obtained by Gamma Irradiation
(MDPI, 2024) Şen, Ayşe; GÜMÜŞ, TAMER; Temel, Aslıhan; Öztürk, İrfan; ÇELİK, ÖZGE
The bread wheat cultivar (Triticum aestivum L. cv. Sagittario) as a parental line and its mutant, drought-tolerant lines (Mutant lines 4 and 5) were subjected to polyethylene glycol (PEG)-induced drought. Drought stress resulted in decreased chlorophyll levels and the accumulation of proline and TBARS, despite increases in activities of catalase, peroxidase, and superoxide dismutase enzymes. Transcription of the genes encoding these enzymes and delta-1-pyrroline 5-carboxylase synthetase was induced by drought. 2-DE gel electrophoresis analysis identified differentially expressed proteins (DEPs) in the mutant lines, which are distinguished by "chloroplast", "mitochondrion", "pyruvate dehydrogenase complex", and "homeostatic process" terms. The drought tolerance of the mutant lines might be attributed to improved photosynthesis, efficient ATP synthesis, and modified antioxidant capacity. In addition to proteomics data, the drought tolerance of wheat genotypes might also be assessed by chlorophyll content and TaPOX gene expression. To our knowledge, this is the first proteomic analysis of gamma-induced mutants of bread wheat. These findings are expected to be utilized in plant breeding studies.
Open Access
Briot-Bouquet Differential Subordinations for Analytic Functions Involving the Struve Function
(MDPI, 2022) ÇETİNKAYA, ASENA; Cotirla, Luminita-Ioana
We define a new class of exponential starlike functions constructed by a linear operator involving normalized form of the generalized Struve function. Making use of a technique of differential subordination introduced by Miller and Mocanu, we investigate several new results related to the Briot-Bouquet differential subordinations for the linear operator involving the normalized form of the generalized Struve function. We also obtain univalent solutions to the Briot-Bouquet differential equations and observe that these solutions are the best dominant of the Briot-Bouquet differential subordinations for the exponential starlike function class. Moreover, we give an application of fractional integral operator for a complex-valued function associated with the generalized Struve function. The significance of this paper is due to the technique employed in proving the results and novelty of these results for the Struve functions. The approach used in this paper can lead to several new problems in geometric function theory associated with special functions.
Open Access
Deciphering the Mechanism of Melatonin-Induced Enhancement of Photosystem II Function in Moderate Drought-Stressed Oregano Plants
(MDPI, 2024) Moustaka, Julietta; Sperdouli, Ilektra; İŞGÖREN, SUMRUNAZ; Şaş, Begüm; Moustakas, Michael
Melatonin (MT) is considered as an antistress molecule that plays a constructive role in the acclimation of plants to both biotic and abiotic stress conditions. In the present study, we assessed the impact of 10 and 100 μM MT foliar spray, on chlorophyll content, and photosystem II (PSII) function, under moderate drought stress, on oregano (Origanum vulgare L.) plants. Our aim was to elucidate the molecular mechanism of MT action on the photosynthetic electron transport process. Foliar spray with 100 μM MT was more effective in mitigating the negative impact of moderate drought stress on PSII function, compared to 10 μM MT. MT foliar spray significantly improved the reduced efficiency of the oxygen-evolving complex (OEC), and PSII photoinhibition (Fv/Fm), which were caused by drought stress. Under moderate drought stress, foliar spray with 100 μM MT, compared with the water sprayed (WA) leaves, increased the non-photochemical quenching (NPQ) by 31%, at the growth irradiance (GI, 205 μmol photons m−2 s−1), and by 13% at a high irradiance (HI, 1000 μmol photons m−2 s−1). However, the lower NPQ increase at HI was demonstrated to be more effective in decreasing the singlet-excited oxygen (1O2) production at HI (−38%), in drought-stressed oregano plants sprayed with 100 μM MT, than the corresponding decrease in 1O2 production at the GI (−20%), both compared with the respective WA-sprayed leaves under moderate drought. The reduced 1O2 production resulted in a significant increase in the quantum yield of PSII photochemistry (ΦPSII), and the electron transport rate (ETR), in moderate drought-stressed plants sprayed with 100 μM MT, compared with WA-sprayed plants, but only at the HI (+27%). Our results suggest that the enhancement of PSII functionality, with 100 μM MT under moderate drought stress, was initiated by the NPQ mechanism, which decreased the 1O2 production and increased the fraction of open PSII reaction centers (qp), resulting in an increased ETR. © 2024 by the authors.
Open Access
The Efficacy of Night Bracing in the Treatment of Adolescent İdiopathic Scoliosis: A Systematic Review
(MDPI, 2024) Çolak, Tuğba Kuru; Dereli, Elif Elçin; Akçay, Burçin; APTİ, ADNAN; Maeso, Santiago Lasa
Background/Objectives: The effectiveness of night braces alone or in combination with other treatments for adolescent idiopathic scoliosis remains unclear. This systematic review study aimed to review and analyze the available literature to determine whether night braces are an effective treatment for idiopathic scoliosis. Methods: A total of 162 databases, including Cochrane Library (reviews, protocols, trials), Web of Science, PubMed, Medline, Scopus, PEDro, CINAHL (EBSCO), Ovid and Google Scholar, were searched for published articles from inception to February 2024. The available literature was screened by the following terms: "scoliosis and night-time brace", "scoliosis and night brace", "scoliosis and part-time bracing", "scoliosis and Providence" and "scoliosis and Charleston". Results: Twenty studies were included; only one study was a randomized controlled trial, and most of the studies were retrospectively designed. Providence, Charleston and Boston braces were used as night braces. The Cobb angle was evaluated in all studies, and Cobb angle change after treatment and surgical treatment rates were the parameters that were evaluated the most. In one study, the angle of trunk rotation, quality of life, perception of spinal appearance, and physical activity level were measured. In one study, sagittal plane assessments were performed in addition to the Cobb angle. Conclusions: The results of this review suggest that there is no evidence to support the use of night braces in the treatment of adolescent idiopathic scoliosis. Randomized controlled trials with a well-designed methodology are needed to determine the efficacy of night braces.
Open Access
Examining the Necessity of Evaluating Life Skills in Health Education
(Journal of Research and Health, 2024) Darabi, Fatemeh; SHABANI, SEVİL MOMENİ
Open Access
Gebe Okulu Eğitimcilerinin Gözüyle Endokrin Bozucular: Nitel Bir Çalışma
(Atatürk Üniversitesi, 2024) MİRAL, MUKADDES TURAN; Siyahtaş, Gamze Fışkın
Amaç: Bu araştırmanın amacı gebe okulu programlarında eğitimci olarak görev alan ebe ve hemşirelerin endokrin bozucular konusundaki bilgi ve tutumlarını incelemektir. Yöntem: Fenomenolojik tipte tasarlanan araştırmanın evreni, İstanbul ilindeki gebe okulu programlarında eğitimci olarak görev yapan 44 ebe/hemşireden oluşmuştur (N=44). Ölçüt örnekleme yöntemi kullanılarak örneklem veri doygunluğu takip edilmiş ve doygunluk sağlandığında veri toplama işlemi tamamlanmıştır (n=7). 13 Eylül 2021 tarihinde yapılan araştırmada, veriler odak grup yöntemi ile araştırmacılar tarafından oluşturulan yarı yapılandırılmış görüşme formuyla toplanmıştır. Nicel veriler, tanımlayıcı istatistiksel analizler kullanılarak, nitel veriler ise içerik analiziyle değerlendirilmiştir. Bulgular: Ebe ve hemşirelerin görüşme formuna verdikleri cevaplar doğrultusunda; endokrin bozucuların önemi, endokrin bozucular bilgisi, endokrin bozucular farkındalığı oluşturma ve gebe eğitimine entegrasyon şeklinde dört adet tema oluşturulmuştur. Prenatal dönem eğiticilerinin endokrin bozucuların öneminin farkında olmalarına rağmen konu hakkındaki bilgilerinin yetersiz olduğu belirlenmiştir. Ayrıca katılımcıların konunun prenatal eğitimlerde yer alması ve farkındalık geliştirilebilmesi için çeşitli önerilerinin bulunduğu saptanmıştır. Sonuç: Ebe ve hemşirelerin endokrin bozuculara yönelik çok fazla bilgilerinin olmadığı hatta kısmen yanlış bilgilere sahip oldukları görülmüştür. Eğitici eğitimlerinin içeriğine endokrin bozucularla ilgili konuların eklenerek bilinçlendirme çalışmalarının arttırılması gerektiği sonucuna varılmıştır.
Open Access
In Silico Evaluation of ERQ Bioactive Tripeptide as an Anticancer Agent and an Inhibitor of SARS-CoV-2 Enzymes
(Istanbul University Press, 2024) Yılmaz, Gözde; Çelik, Sefa; Özel, Ayşen Erbölükbaş; AKYÜZ, SEVİM
Objective: Short peptides play a significant role in exploring drugs with higher selectivity and fewer side effects in cancer and COVID-19 therapies. This study evaluated the anticancer and anti-COVID-19 activities of Glu-Arg-Gln (ERQ) tripeptide for the first time. To discover the potentiality of the tripeptide as an anticancer and as a SARS-CoV-2 inhibitor, molecular docking analysis of ERQ tripeptide with DNA (PDB ID: 1BNA) and a variety of SARS-CoV-2 enzymes, namely. Main protease (PDB IDs: 6M03, 6LU7) and Spike glycoprotein (PDB ID: 6VXX) were performed. Materials and Methods: To determine the binding efficiency of ERQ to target DNA and proteins, molecular docking processes were carried out using the Autodock Vina program. The sorts of bonds and interacting residues in ERQ/DNA and ERQ/protein complexes were determined. Results: Molecular docking simulations of ERQ tripeptide against 1BNA, 6M03, 6LU7, and 6VXX were performed, and the interactions between the docked ligand and target residues were determined. The binding mechanisms of ERQ with the receptors were clarified. The binding affinities of ERQ towards the targets were predicted to be between -6.3 and -6.7 kcal/mol. ERQ showed the highest binding affinity to Spike glycoprotein (6VXX), with an estimated binding energy of -6.7 kcal/mol. Conclusion: Molecular docking simulations revealed the potential of ERQ tripeptide as an anticancer and anti-COVID-19 agent. High binding affinity against 1BNA (-6.4 kcal/mol), 6M03 (-6.3 kcal/mol), 6LU7 (-6.6 kcal/mol), and 6VXX (-6.7 kcal/mol) indicated that ERQ could be an excellent new natural therapy for the treatment of cancer and COVID-19. © 2024 Istanbul University Press. All rights reserved.
Open Access
Indigo Carmine Binding to Cu(II) in Aqueous Solution and Solid State: Full Structural Characterization Using NMR, FTIR and UV/Vis Spectroscopies and DFT Calculations
(MDPI, 2024) Braz, Sofia; Justino, Licinia L. G.; Ramos, M. Luisa; FAUSTO, RUI
The food industry uses indigo carmine (IC) extensively as a blue colorant to make processed food for young children and the general population more attractive. Given that IC can act as a ligand, this raises concerns about its interactions with essential metal ions in the human body. In view of this interest, in the present investigation, the copper(II)/indigo carmine system was thoroughly investigated in aqueous solution and in the solid state, and the detailed structural characterization of the complexes formed between copper(II) and the ligand was performed using spectroscopic methods, complemented with DFT and TD-DFT calculations. NMR and UV/Vis absorption spectroscopy studies of the ligand in the presence of copper(II) show changes that clearly reveal strong complexation. The results point to the formation of complexes of 1:1, 1:2 and 2:1 Cu(II)/IC stoichiometry in aqueous solution, favored in the pH range 6-10 and stable over time. DFT calculations indicate that the coordination of the ligand to the metal occurs through the adjacent carbonyl and amine groups and that the 1:1 and the 2:1 complexes have distorted tetrahedral metal centers, while the 1:2 structure is five-coordinate with a square pyramidal geometry. FTIR results, together with EDS data and DFT calculations, established that the complex obtained in the solid state likely consists of a polymeric arrangement involving repetition of the 1:2 complex unit. These results are relevant in the context of the study of the toxicity of IC and provide crucial data for future studies of its physiological effects. Although the general population does not normally exceed the maximum recommended daily intake, young children are highly exposed to products containing IC and can easily exceed the recommended dose. It is, therefore, extremely important to understand the interactions between the dye and the various metal ions present in the human body, copper(II) being one of the most relevant due to its essential nature and, as shown in this article, the high stability of the complexes it forms with IC at physiological pH.
Open Access
Life Cycle Assessment Analysis Based on Material Selection in Sustainable Airport Buildings
(MDPI, 2024) UĞURAL, MEHMET NURETTİN; ÖZYILMAZ, MERVE RÜYA; Burgan, Halil Ibrahim
Sustainable airport buildings aim to minimize environmental impacts through energy efficiency, water conservation, and waste management. This is achieved by employing green building materials and utilizing renewable energy sources to reduce their carbon footprint. In this study, life cycle assessment (LCA) was conducted to assess the environmental impacts of three main construction materials—concrete, steel, and wood—used in sustainable airport buildings. These materials were selected for their widespread use in eight different airport terminal buildings with sustainability certifications. The environmental impacts of these materials were calculated and compared using OpenLCA 1.9.0 software and the ECOinvent database, adhering to the standards set forth by the Environmental Product Declaration (EPD) initiative. The findings indicate that wood, as a construction material, has a significantly lower impact on global warming compared to steel and concrete, with a global warming potential (GWP) ratio of less than 60%. Steel, with a GWP of approximately 90% of that of concrete, also showed a lower impact than concrete. Additionally, other environmental impacts, such as stratospheric ozone depletion potential (ODP) and acidification potential (AP), were also examined, highlighting the trade-offs associated with each material. © 2024 by the authors.
Open Access
A New Azide-Bridged Polymeric Manganese (III) Schiff Base Complex with an Allylamine-Derived Ligand: Structural Characterization and Activity Spectra
(MDPI, 2024) Talebi, Aynaz; Salehi, Mehdi; Jesus, A. J. Lopes; Kubicki, Maciej; FAUSTO, RUI; Golbedaghi, Reza
This paper reports the synthesis and structural characterization of a novel azide-bridged polymeric manganese (III) Schiff base complex, using 2-((allylimino)methyl)-6-ethoxyphenol as a ligand. The crystal structure of the synthesized compound, elucidated by single-crystal X-ray diffraction analysis, indicates that it crystallizes in the monoclinic space group P21/c. The complex is found to display an octahedral geometry in which the central manganese Mn(III) coordinates with two bidentate donor Schiff base ligands via oxygen and nitrogen atoms. In addition, the metallic centers are linked together to form a one-dimensional chain bridged by end-to-end azide ligands. To offer a more thorough characterization of the synthesized compound, the study incorporates experimental data from FT-IR, UV-Vis, and cyclic voltammetry, alongside computational results from Hirshfeld surface analysis and DFT calculations conducted for both the ligand and complex. The computational analyses provided valuable insights into the intrachain and interchain interactions within the crystal structure, clarified the conformational characteristics of the isolated ligand molecule, and aided in the interpretation of the experimental IR spectra. Furthermore, an assessment of the compound’s drug-like properties was conducted using activity spectra for substances (PASS) predictions, revealing potential pharmacological activities. © 2024 by the authors.
Open Access
Recycling Ophthalmic Lens Wastewater in a Circular Economy Context: A Case Study with Microalgae Integration
(MDPI, 2024) FAUSTO, RUI
Water pollution poses a global threat to ecosystems and human health and is driven by the presence of various contaminants in wastewater, including nano- and microplastics. Despite the magnitude of this problem, the majority of global wastewater is released untreated into water bodies. To combat this issue, a multi-strategy approach is needed. This study explores a circular economy-based solution for treating emerging pollutants, particularly wastewater from ophthalmic spectacle lens production. Our approach integrates solid waste materials into polymeric and cement matrices while also utilising wastewater for microalgae cultivation. This innovative strategy focuses on biomass generation and economic valorisation. By adopting a circular economy model, we aim to transform environmental pollutants from wastewater into valuable organic products. A key component of our approach is the utilisation of microalgae, specifically Nannochloropsis sp., known for its high lipid content and resilience. This microalgae species serves as a promising biobased feedstock, supporting the production of innovative biobased products, such as biopolymers, for ophthalmic lens manufacturing. Our interdisciplinary approach combines microalgae technology, analytical chemistry, cement production, and polymer processing to develop a sustainable circular economy model that not only addresses environmental concerns, but also offers economic benefits. This study underscores the potential of harnessing high-value products from waste streams and underscores the importance of circular economy principles in tackling pollution and resource challenges.
Open Access
Structure Preserving Schemes for Coupled Nonlinear Schrödinger Equation
(Institute of Physics, 2024) AKKOYUNLU, CANAN; ŞAYLAN, PELİN
The numerical solution of CNLS equations are studied for periodic wave solutions. We use the first order partitioned average vector field method, the second order partitioned average vector field composition method and plus method. The nonlinear implicit schemes preserve the energy and the momentum. The results show that the methods are successful to get approximation. © 2024 Institute of Physics Publishing. All rights reserved.

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