(İstanbul Kültür Üniversitesi, 2008) Öztürk, Fatma; Daloğlu, Cihan; Açık, Leyla; Kılıç, Mehmet; Koç, Mahmut
Molecula r mutations to proto - oncogene sequences
may be involved in the pathogenesis of human
thyroid neoplasm. Problems on oncogenes and
tumor supressor genes activation in cell circle
could cause tumor. Many oncogenes and tumor
suppressing genes exist in varying percentages in
various types of thyroid cancers. Ras, Gsp, Ret or
Trk oncogenes can be involve in thyroid tumors .
Members of t h e Ras gene family (H-ras, K-ras, and
N-ras) are signal transferring proteins. These
genes codes for 21 kDa GTP binding proteins. We
studied 24 thyroid cancer and 77 control for ras
gene point mutations in two different codons (12
and 13) using a restriction fragment length
polymorphism technique. According to enzyme
digesting, no c-K-ras gene codon 12/13 and N-ras
gene codon 12 point mutation were observed in
any of the samples we studied .
