BeyinMer / Beyin Dinamiği Araştırma Merkezi

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    Auditory Event-Related Delta Oscillatory Responses are Reduced in Patients with Mild Cognitive Impairment
    (Elsevier Science Inc, 360 Park Ave South, New York, Ny 10010-1710 Usa, 2012-04-15) Kurt, Pınar; Emek Savaş, Derya Durusu; Batum, Kübra; Turp Gölbaşı, Bilge; Güntekin, Bahar; Karşıdağ, Sibel; Yener, Görsev; BAŞAR, EROL; 24351; 227002; 142090; 204666; 9297; 142226; 143760
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    Patients with Mild Cognitive Impairment Display Reduced Auditory Event-Related Delta Oscillatory Responses
    (Hindawi Publishing Corporation, 410 Park Avenue, 15Th Floor, #287 Pmb, New York, Ny 10022 Usa, 2014) Kurt, Pınar; Emek Savaş, Derya Durusu; Batum, Kübra; Turp, Bilge; Güntekin, Bahar; Karşıdağ, Sibel; Yener, Görsev; 24351; 227002; 142090; 204666; 9297; 143760
    Background. Event-related oscillations (ERO) may provide a useful tool for the identification of cognitive deficits in mild cognitive impairment (MCI) and Alzheimer's disease (AD). In the present study, we investigate peak-to-peak amplitude of auditory eventrelated delta oscillations of MCI subjects. Method. The study included twenty-two consecutive patients with MCI recruited in neurology clinic and 21 age-and education-matched normal elderly controls. A classical auditory oddball paradigm was used in the experiments. EEG was recorded from F-3, F-z, F-4, C-3, C-z, C-4, P-3, P-z, P-4, O-1, O-z, and O-2 locations. The maximum peak-to-peak amplitudes for each subject's averaged delta response (0.5-2.2Hz) weremeasured. Results. The amplitudes between groups differed significantly at the frontal and mid-centroparietal locations. ANOVA on delta responses revealed a significant effect for groups (F-(1.41) = 4.84, P = 0.033), indicating a larger delta response for healthy controls thanMCI subjects. Post hoc comparisons revealed that peak-to-peak delta response was significantly larger for healthy controls than for MCI over electrode sites F-3, F-z, F-4, C-z, C-4, and Pz. Discussion. Event-related delta frequency band seems to be the most affected oscillatory response in cognitive impairment due to AD. Therefore, it deserves to be investigated as a candidate electrophysiological biomarker in further studies.