Welcome to IKU Academic Digital Archive System
OpenAccess@IKU is Istanbul Kultur University's Institutional Repository , established in June 2014 to digitally store and provide open access to academic and artistic outputs in line with international standards and intellectual property rights. The system includes various outputs such as articles, presentations, theses, books, book chapters, reports, encyclopedias, and works of art produced by the university's faculty members and students.
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Recent Submissions
Letter to the Editor Regarding "Effectiveness of Bracing Combined With Exercise-based Treatment of Adolescent Idiopathic Scoliosis: Assessing the Synergistic Benefits: A Systematic Review"
(Wolters Kluwer, 2025) Çolak, Tuğba Kuru; Akçay, Burçin; APTİ, ADNAN; Dereli, Elif Elçin
Artificial Intelligence-Assisted Optimization of Extraction Enhances the Biological Activity of Phylloporia Ribis
(Nature Publishing Group, 2025) KORKMAZ, ARAS FAHRETTİN; Gürgen, Ayşenur; Krupodorova, Tetiana; Sevindik, Mustafa; Akata, Ilgaz
This research focuses on enhancing the extraction efficiency of Phylloporia ribis and assessing its biological functions. Key parameters including extraction temperature, duration, and ethanol-to-water ratio were optimized through both Response Surface Methodology (RSM) and an integrated Artificial Neural Network-Genetic Algorithm (ANN-GA) approach. The extracts obtained via ANN-GA exhibited greater antioxidant activity and higher concentrations of phenolic constituents such as gallic acid, quercetin, and vanillic acid. Compared to RSM-optimized samples, ANN-GA extracts demonstrated superior free radical scavenging, stronger ferric reducing power, and a more potent dose-dependent inhibition of cell proliferation. In addition, P. ribis extracts showed enzyme-inhibitory properties against acetylcholinesterase and butyrylcholinesterase, suggesting their potential utility in pharmaceutical and biotechnological applications. The ANN-GA method appears to be a promising tool for maximizing both the yield of phenolic compounds and the biological efficacy of extracts. Further advanced biotechnological optimization studies are advised to unlock the full therapeutic potential of P. ribis.
Tailored Multibody Tibiofemoral Joint Model for Precision Care
(Wiley, 2025) KUCHIMOV, SHAVKAT NADIR; Ozkan, Mehmed; Temelli, Yener
Knee motion involves intricate coordination among various anatomical structures. Effective treatment of knee pathologies requires precise identification of deformities and accurate surgical interventions, which often involve rapid tissue modification based on established knowledge. However, motion disorders are typically detected long after surgery. To address this, a simulation environment is proposed to plan and analyze surgical impacts on knee motion. Comprehensive knee joint modeling is crucial for a successful simulation. Clinically accepted movement procedures based on passive knee motion make tibiofemoral articulation modeling sufficient. Proposed model tibiofemoral articulation, incorporating 15 ligaments, tibial and femoral bones, and cartilages. Ligaments' tensile, bones', and cartilages' contact forces (CFs) define internal force interactions. Anatomical structures, their shapes, positions, and attachment points are identified from MRI, ensuring patient-specific modeling. Simulation results are compared to cadaver data using passive knee motion. Two rotational and three translational dependent joint motions (JMs) are compared pairwise. The results are highly correlated with the clinical benchmark. Pearson's correlation show a strong association between experimental and simulated passive knee flexions (PKFs; r > 0.89). The comparison is statistically significant with p < 0.05. Anterior-posterior translation showed the highest correlation (R-2 = 0.994). The findings indicate that the simulated model closely replicates actual knee responses.
Aronia (Chokeberry) Fruit Extract is a Potential Candidate for Managing Metabolic Syndrome in Elderly Patients
(Routledge, 2025) BALTACI, PELİN CİN; Eyupoglu, Ozan Emre; Kankaya, Selin; Yavuzer, Hakan
Objectives: Natural products like Aronia (Aronia melanocarpa) are promising candidates to manage metabolic abnormalities due to their bioactive compounds. This study aimed to evaluate the effects of daily Aronia fruit extract supplementation on the components of Metabolic Syndrome (MetS), cardiovascular health, inflammation, and atherogenic markers in elderly patients. Methods: Our study is a randomized controlled trial of 44 subjects (12 males and 32 females) diagnosed with MetS. The study groups were the intervention group (n = 22), which received daily 10 g Aronia fruit extract for 8 wk, and the control group, which did not receive the extract (n = 22). Demographics, dietary intake, and food habits were recorded by an extended survey. Baseline and post-intervention measurements of anthropometric data, dietary intake, cardiovascular parameters, blood pressure, blood lipid composition, plasma atherogenic index (PAI), triglyceride (TG), and the triglyceride-glucose index (TyG), and biomarkers of inflammation, including tumor necrosis factor-alpha (TNF-α), Interleukin 6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and oxidative stress biomarkers, were represented as delta values. Results: No significant changes were observed in anthropometric measurements within or between groups over the 8 wk. However, several cardiovascular health parameters, including diastolic blood pressure (−10.00 mmHg), PAI index (−0.06), triglycerides (−9.0 mg/dL), and low-density lipoprotein cholesterol (LDL-C) (−6.30 mg/dL) were significantly decreased in the intervention group compared to the control group at the end of 8 wk of use (p < 0.05). Inflammatory markers TNF-α (−7.87 pg/mL) and IL-6 (−0.58 pg/mL), as well as oxidative stress markers, oxidized low-density lipoprotein (ox-LDL) (−132.17 U/L) and small dense low-density lipoprotein (sdLDL) (−0.79 mg/dL), also significantly decreased in the intervention group (p < 0.001). Conclusion: Our findings suggest that daily supplementation with Aronia fruit extract significantly improves cardiovascular health markers and reduces inflammation and oxidative stress in elderly patients with MetS. Hence, Aronia extract may be an effective dietary supplement for managing MetS in high-risk groups.
Optical Soliton Solution of the Benney–Roskes/Zakharov–Rubenchik Systems
(World Scientific, 2025) UÇAR, MEHMET FATİH
The study focuses on deriving optical soliton solutions for the Benney–Roskes (BR) and Zakharov–Rubenchik (ZR) system. To achieve this, complex wave transformations are applied to convert the system of partial differential equations (PDEs) into a more manageable form of ordinary differential equation (ODE). This transformation simplifies the analysis and facilitates the extraction of exact solutions. The new Kudryashov method (nKM) is employed to solve the resulting nonlinear ODE (NODE). This powerful analytical technique allows for the derivation of various types of soliton solutions, including bright solitons, kink solitons, and singular solitons. Each type of soliton represents different physical phenomena and wave behaviors, providing a comprehensive understanding of the system’s dynamics. The study includes the visualization of the obtained soliton solutions through graphical representations. These visualizations help in understanding the spatial and temporal evolution of the solitons and their interaction with the medium. Furthermore, the study analyzes how changes in the system’s parameters individually affect the shape, amplitude, and width of the solitons. This parametric analysis is crucial for predicting and controlling soliton behavior in practical applications. These are the main distinctive parts and novelties of this study. By deriving and analyzing soliton solutions, the study provides deeper insights into the nonlinear interactions within the BR and ZR system. Understanding these interactions is essential for applications in optical communications, where solitons can be used to transmit information over long distances without significant loss or distortion.