Publication:
Fetuin-A 742 (C/T) and 766 (C/G) polymorphic sites are associated with increased risk of myocardial infarction in older patients (40 years of age)

dc.contributor.authorÇoker Gürkan, Ajda
dc.contributor.authorPalavan Ünsal, Zeynep Narçın
dc.contributor.authorARISAN, ELİF DAMLA
dc.contributor.authorGENÇ, SELMA
dc.contributor.authorYERLİKAYA, PINAR OBAKAN
dc.contributor.authorCOŞKUN, DENİZ
dc.contributor.authorID125860tr_TR
dc.contributor.authorID113920tr_TR
dc.contributor.authorID156421tr_TR
dc.contributor.authorID6125tr_TR
dc.date.accessioned2018-07-13T07:29:40Z
dc.date.available2018-07-13T07:29:40Z
dc.date.issued2015-07
dc.description.abstractInflammation and genetics have key roles in the pathogenesis of atherosclerosis, and the etiology of myocardial infarction (MI). Recent studies have indicated that lower serum levels of fetuin-A may accelerate the vascular mineralization process, which leads to pathophysiological conditions, such as coronary heart disease and chronic renal failure. The aim of the present study was to evaluate the association between specific fetuin-A polymorphisms (742 and 766) that are associated with circulating serum levels, and MI cases. The study consisted of 292 participants; 146 healthy control subjects and 146 patients with MI. The patient group was divided into two subgroups: 56 MI40 years and 90 MI40 years. The genotype distribution of fetuin 742 (C/T) and fetuin 766 (C/G) were determined by restriction enzyme digestion of polymerase chain reaction products. A significant difference was determined between the patients with MI and the control subjects with regards to fetuin-A 742 C/T gene polymorphism (P=0.028), regardless of age. Genotype distributions of fetuin-A 742 (C/G, P= 0.004) and 766 (C/T, P=0.017) were statistically different in the older patients with MI (MI40 years old), as compared with the healthy controls; however, there were no significant differences between the younger patients with MI and the controls, with regards to fetuin-A 742 C/T (P=0.519) and 766 C/G (P=0.653) gene polymorphisms. In addition, an association was observed between the presence of fetuin-A 742 T and 766 G alleles, and MI cases. The present study demonstrates that fetuin-A 742 (C/T) and 766 (C/G) genotypes may be risk factors for MI in patients older than 40 years of age.tr_TR
dc.identifier.issn1791-2997
dc.identifier.other1791-3004
dc.identifier.pubmed25815703
dc.identifier.pubmed25815703en
dc.identifier.urihttps://doi.org/10.3892/mmr.2015.3521
dc.identifier.urihttps://hdl.handle.net/11413/2066
dc.identifier.wos358134400186
dc.identifier.wos358134400186en
dc.language.isoen_UStr_TR
dc.publisherSpandidos Publ Ltd, Pob 18179, Athens, 116 10, Greecetr_TR
dc.relationMolecular Medicine Reportstr_TR
dc.subjectFetuin-Atr_TR
dc.subjectMyocardial infarctiontr_TR
dc.subjectSingle nucleotide polymorphismstr_TR
dc.subjectAlpha(2)-Heremans-Schmid Glycoprotein/Fetuin-Atr_TR
dc.subjectCoronary-artery calcificationtr_TR
dc.subjectUnstable anginatr_TR
dc.subjectCardiovascular-diseasestr_TR
dc.subjectGene polymorphismstr_TR
dc.subjectHeart-diseasetr_TR
dc.subjectGlobal burdentr_TR
dc.subjectSerumtr_TR
dc.subjectAhsgtr_TR
dc.titleFetuin-A 742 (C/T) and 766 (C/G) polymorphic sites are associated with increased risk of myocardial infarction in older patients (40 years of age)tr_TR
dc.typeArticle
dspace.entity.typePublication
local.indexed.atpubmed
local.indexed.atwos
relation.isAuthorOfPublication3d33e154-a50c-46b8-ad6e-25a26bf11cf0
relation.isAuthorOfPublication0e4cdd7a-4bc0-4b19-9aad-a55731ff14a2
relation.isAuthorOfPublication387670e2-5a88-4937-b3da-1dda9aedfbdd
relation.isAuthorOfPublication44df5e00-bc42-470a-98e0-12025ec91466
relation.isAuthorOfPublication.latestForDiscovery3d33e154-a50c-46b8-ad6e-25a26bf11cf0

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