Publication: 39 spatial arrangement of the animal male germ cell genome: II. 2d-3d Simulation and visualization of spatial configuration of major chromosome 2 in Drosophila sperm
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Date
2007-09
Authors
Alexandrov, Igor D.
Stepanenko, Victor A.
Alexandrova, Margarita V.
Journal Title
Journal ISSN
Volume Title
Publisher
İstanbul Kültür Üniversitesi
Abstract
Data on the non-random distribution of radiationinduced
inversion breakpoints were used as genetic
markers for 2D and 3D modeling of the largescale
architecture of the chromosome 2 in
Drosophila sperm genome at the time of irradiation.
During modeling, Gmax program with application
of splines, the additional objects and operations
as well as the methods of visualization of
macromolecular biostructures were employed. A
specific megarosette-loop model of spatial
arrangement of chromatin fiber in the haploid
sperm nucleus can account well for the experimental
data.
Description
Keywords
2D/3D models, large-scale chromosome geometry, sperm genome, Drosophila, 2D/3D modelleri, sperm genom, büyük ölçekli kromozom geometrisi