Welcome to IKU Academic Digital Archive System
OpenAccess@IKU is Istanbul Kultur University's Academic Digital Archive System, established in June 2014 to digitally store and provide open access to academic and artistic outputs in line with international standards and intellectual property rights. The system includes various outputs such as articles, presentations, theses, books, book chapters, reports, encyclopedias, and works of art produced by the university's faculty members and students.
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Sözcük Ölümü ve Erinç Edatı Üzerine
(Türk Dil Kurumu, 2025) TÜRK, VAHİT
Bir dilde eş anlamlı sözlerin uzun süre bir arada yaşaması çok karşılaşılan bir durum değildir. Dillerde sözlerin kullanımdan düşmesinin çeşitli nedenleri vardır. Nedenlerden bir kısmıyla bütün dillerde karşılaşılır, bir kısmı ise dillerin kendi tarihiyle ilgilidir. Söz ölümü genellikle bir sözün anlam alanına dilin kendi kaynağından ya da başka bir dilden bir sözün girmesi nedeniyle olur. Ana yurttan ya da ana kitleden uzaklaşan kitlelerin dilinde zaman içinde değişmeler görülmeye başlanır ve bu durum lehçe oluşumlarının da asıl nedeni olur. Türk dili, sözcükleri öncelikle ad ve eylem olarak iki ana bölüme ayırır. Sıfat, zarf, zamir; sözcüklerin cümle içinde yüklendikleri görev adlarıdır. Türk dilinin yapısında edatın olmadığı, bu sözcük çeşidinin sonradan adlardan ya da eylemlerden türetildiği dilcilerin benimsediği bir görüştür. Edatlar, kalıplaşmış ve kendi başlarına anlam yükü olmayan ancak cümlenin anlamına katkısı olan sözlerdir. Erinç, Türk dilinin ana yardımcı eylemlerinden biri olan er- eyleminden türemiş, Bengü Taşlarda, Uygur ve Hakanlı metinlerinde karşılaşılan bir sözcüktür. Bu sözcüğün cümleye katkısı, anlama kesinlik ya da olasılık katmaktır. Hakanlı metinlerinden sonra yazı dilinde karşılaşılmayan bu sözcük yerini er- ve özellikle tur- eyleminin geniş zaman çekimli biçimlerine bırakmıştır. Bugünkü Türk yazı dillerinde de erinç sözünün cümleye kattığı işlevle turur biçiminden gelen -dIr bildirme ya da kuvvetlendirme eki kullanılmaktadır.
Photochemistry of 2-Aminooxazole: A Matrix-isolation and Computational Study of a Putative Key Prebiotic Molecule
(Royal Society of Chemistry, 2025) Nunes, Cláudio M.; Viegas, Luís P.; Tripathi, Anuj; Braz, Sofia; FAUSTO, RUI
2-Aminooxazole 1 is a key intermediate in plausible prebiotic pathways to activated pyrimidine ribonucleotides. However, its photochemistry and underlying reaction mechanism remain unclear. Here, we present a combined matrix-isolation infrared spectroscopic and computational investigation of the UV-induced photochemistry of 1. Narrowband irradiation at 220 nm of 1 isolated in cryogenic Ar or N2 matrices leads mainly to 3-amino-1-formyl nitrile ylide. Minor products included 3-amino-2-formyl-2H-azirine and, most likely, two tautomeric 2-iminooxazoles. The nitrile ylide photoreverts to 1 (380 nm), whereas 2-formyl-2H-azirine photoisomerizes to imidoylketene (320 nm). Spin–flip time-dependent density functional (SF-TDDFT) computations reveal a cascade of conical intersections following excitation to the S2 state of 1, providing a mechanistic explanation for the observed C–O ring-opening and predominant formation of the nitrile ylide. Overall, these findings elucidate the photoreactivity mechanism of 2-aminooxazole and can contribute to understanding the behavior of this pivotal molecule under early Earth UV conditions.
The naa40 Deletion Is Associated with Extended Chronological Lifespan and Changes in Energy and Lipid Metabolism in Fission Yeast
(Pleiades Publishing, 2025) Çalici Z; BUSE, ÖZDEN; Tarhan Ç.
Abstract: Aging is associated with various physiological and molecular changes, including epigenetic reprogramming and metabolic remodeling. N-alpha-acetyltransferase 40 (NAA40), encoded by naa40, has emerged as a key factor connecting chromatin dynamics to cellular metabolism among epigenetic regulators. NAA40 specifically acetylates the N-termini of histones H4 and H2A, thereby influencing gene expression and maintaining the metabolic balance. In mammalian systems, the depletion of NAA40 increases intracellular acetyl-CoA levels, which impacts lipid metabolism and stress response pathways. However, the overall effects of naa40 deletion in organisms are not fully understood. In this study, we examined the functional consequences of naa40 deletion in Schizosaccharomyces pombe by analyzing changes in chronological lifespan, glucose consumption, lipid metabolism, and oxidative stress. Our findings indicate that the loss of NAA40 significantly extends the lifespan, decreases glucose utilization, alters lipid distribution, and reduces lipid peroxidation. These metabolic changes are similar to the cellular adaptations observed under calorie restriction. Our results support a model in which naa40 deletion triggers chromatin remodeling and reprograms the metabolic pathways, ultimately leading cells to a quiescent-like state characterized by increased stress resistance and extended survival. These findings underscore the importance of NAA40 as a critical link between epigenetic regulation and the mechanisms that promote metabolic longevity.
COŞKUN, ASLIHAN
Dr. Öğr. Üyesi
Genetic Codes of Housing: Morphological Reading of Traditional Antalya Houses
(MDPI, 2025) COŞKUN, ASLIHAN; Haştemoğlu, Hasan Şehmuz
This study focuses on the traditional houses of Kaleiçi, Haşim İşcan, and Balbey neighborhoods, which constitute the historical center of Antalya and reflect the cultural continuity of the organic urban texture dating back to the Hellenistic period. The aim is to reveal how climatic, topographic and cultural factors shape the spatial organization of these traditional houses. Using the space syntax method, the study analyzes nine sample houses to examine their morphological structure. The findings show that while the ground floors are mostly arranged as service areas and the upper floors as living spaces, the sofa emerges as the most integrated space despite varying depths across neighborhoods. Moreover, spatial differences between the neighborhoods indicate contextual diversity, yet the persistence of sofa-centered organization underlines the role of cultural continuity in housing morphology. By emphasizing the centrality of the sofa and demonstrating how cultural factors sustain typological patterns over time, this study contributes to the literature on space syntax-based morphology and offers practical insights for contemporary housing design that considers climatic and cultural contexts.