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Roscovitine treatment inhibited cell proliferation and induced apoptosis via modulating activity of Stat3 and Foxo1 under control of Akt in LNCaP prostate cancer cells

Arısan, Elif Damla; Gümüşkaptan, Çağrı; Berrak, Özge; Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Ünsal, Zeynep Narçin (2015)

Cyclin dependent kinases (CDKs) are known activators of nuclear hormone receptors; such as androgen receptor (AR) via modulating several cell survival signaling routes. However, novel CDK inhibitors might also prevent cell ...

Purvalanol and roscovitine exert their apoptotic effect differently in terms of mTOR downstream signalling route

Doğruel, Tuğçe; Berrak, Özge; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Ünsal, Zeynep Narçin (2015)

Forced Bcl-2 expression induced prevented roscovitine induced-autophagy via in PC3 cells” 3rd AntiCancer Agent Development Congress

Acar, Sevilay; Berrak, Özge; Gümüşkaptan, Çağrı; Obakan Yerlikaya, Pınar; Arısan, Elif Damla (2015)

Diminished Cyclin Dependent Kinase Activity and mTOR Are Critical In The Cell Death DecisionThrough Affecting STAT Signalling Differently In Prostate Cancer Cells

Arısan, Elif Damla; Gümüşkaptan, Çağrı; Berrak, Özge; Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Ünsal, Zeynep Narçin (2017)

The combination of rapamycin with purvalanol and roscovitine induces autophagy through PI3K/AKT and Ras/Raf/Erk pathways regulation in DU 145 prostate cancer cells

Berrak, Özge; Arısan, Elif Damla; Yerlikaya, Pınar Obakan; Çoker Gürkan, Ajda; Ünsal, Zeynep Narçin (2014)

Investigation the role of CDK inhibitors on ER stress-mediated apoptosis in LNCaP prostate cancer cells

Hacıbektaşoğlu, Harbiye; Arısan, Elif Damla; Berrak, Özge; Gümüşkaptan, Çağrı; Çoker Gürkan, Ajda; Obakan Yerlikaya, Pınar; Ünsal, Zeynep Narçin (2015)

Investigation the potential role of FoxO members in the purvalanol and roscovitine-induced autophagy in LNCaP and DU 145 prostate cancer cells

Berrak, Özge; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Ünsal, Zeynep Narçin (2015)

mTOR signaling alters cell fate following inhibition of cyclin-dependent kinases due to androgen receptor status in prostate cancer cells

Arısan, Elif Damla; Berrak, Özge; Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Ünsal, Zeynep Narçin (2014)

The combination of rapamycin with CDK inhibitors purvalanol and roscovitine induces autophagy by modulating different mTOR complexes in DU 145 prostate cancer cells