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Orlistat is a fatty acid synthase (FASN) inhibitor caused the modulation of AMPK and lipogenesis signaling axis in PC3 prostate cancer cells but not in PNT1A prostate epithelial cells

Nebiler, Esra; Adacan, Kaan; Arısan, Elif Damla; Çoker Gürkan, Ajda; Obakan Yerlikaya, Pınar; Palavan Ünsan, Narçın (2017)

Prostate cancer is one the leading cancer type after lung cancer among male. Obesity is one of the known risk factor for developing highly aggressive and metastatic prostate cancer, which is an obstacle in cancer therapy. ...

Epibrassinolide Treatment Caused Autophagy or Apoptosis Decision in a Time-Dependent Manner through ER Stress in Colon Cancer Cells

Obakan Yerlikaya, Pınar; Adacan, Kaan; Arısan, Elif Damla; Çoker Gürkan, Ajda; Ünsal, Zeynep Narçin (2017)

Epibrassinolide (EBR) is a natural plant polyhydroxysteroid with structural similarity to steroid hormones. Lately we showed by SILAC assay that EBR treatment induces apoptosis by significantly altering the expressions of ...

Epibrassinolide controls polyamine levels to induce autophagy in Mouse Embryonic Fibroblasts

Adacan, Kaan; Obakan Yerlikaya, Pınar; Arısan, Elif Damla; Çoker Gürkan, Ajda; Ünsal, Zeynep Narçin (2016)

EBR induced autophagy in colon carcinoma cell lines

Adacan, Kaan; Obakan Yerlikaya, Pınar; Arısan, Elif Damla; Çoker Gürkan, Ajda; Ünsal, Zeynep Narçin (2015-07)

Endoplasmic reticulum stress is activated after epibrassinolide treatment leading autophagy in wild type and Atg5/ mouse embryonic fibroblasts: a survival mechanism in nonmalignant cells.

Adacan, Kaan; Obakan Yerlikaya, Pınar; Arısan, Elif Damla; Çoker Gürkan, Ajda; Ünsal, Zeynep Narçin (2017)

Autophagy is a process of cellular selfdegradation during which macromolecules, damaged/aged organelles and proteins are delivered to the lysosome by engulfment within doublemembrane vesicles. The accumulation of ...