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Inhibition of autophagy by 3-MA potentiates purvalanol-induced apoptosis in Bax deficient HCT 116 colon cancer cells 

Çoker Gürkan, Ajda; Arısan, Elif Damla; Obakan, Pınar; Güvenir, Esin; Palavan Unsal, Narçin (Elsevier Inc, 525 B Street, Ste 1900, San Diego, Ca 92101-4495 Usa, 2014-10-15)
The purine-derived analogs, roscovitine and purvalanol are selective synthetic inhibitors of cyclin-dependent kinases (CDKs) induced cell cycle arrest and lead to apoptotic cell death in various cancer cells. Although a ...
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Roscovitine-treated He La cells finalize autophagy later than apoptosis by downregulating Bcl-2 

Çoker Gürkan, Ajda; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Özfiliz Kılbaş, Pelin; Köse, Betsi; Bıçkıcı, Güven; Palavan Ünsal, Zeynep Narçın (Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2015-03)
The cell cycle is tightly regulated by the family of cyclin-dependent kinases (CDKs). CDKs act as regulatory factors on serine and threonine residues by phosphorylating their substrates and cyclins. CDK-targeting drugs ...
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mTOR is a fine tuning molecule in CDK inhibitors-induced distinct cell death mechanisms via PI3K/AKT/mTOR signaling axis in prostate cancer cells 

Berrak, Özge; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Palavan Ünsal, Zeynep Narçın (Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands, 2016-10)
Purvalanol and roscovitine are cyclin dependent kinase (CDK) inhibitors that induce cell cycle arrest and apoptosis in various cancer cells. We further hypothesized that co-treatment of CDK inhibitors with rapamycin, an ...
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Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells 

Obakan, Pınar; Arısan, Elif Damla; Özfiliz Kılbaş, Pelin; Çoker Gürkan, Ajda; Palavan Unsal, Narçin (Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands, 2014)
Purvalanol A is a specific CDK inhibitor which triggers apoptosis by causing cell cycle arrest in cancer cells. Although it has strong apoptotic potential, the mechanistic action of Purvalanol A on significant cell signaling ...
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Cyclin-dependent kinase inhibitors, roscovitine and purvalanol, induce apoptosis and autophagy related to unfolded protein response in HeLa cervical cancer cells 

Özfiliz Kılbaş, Pelin; Sarıkaya, Bahar; Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Arısan, Elif Damla; Temizci, Benan; Palavan Ünsal, Zeynep Narçın (Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands, 2018-10)
Roscovitine (Rosc) and purvalanol (Pur) are competitive inhibitors of cyclin-dependent kinases (CDKs) by targeting their ATP-binding pockets. Both drugs are shown to be effective to decrease cell viability and dysregulate ...
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mTOR signalling alters cell fate following inhibition of cyclin-dependent kinases due to androgen receptor status in prostate cancer cells 

Arısan, Elif Damla; Berrak, Ozge; Obakan, Pınar; Çoker Gürkan, Ajda; Palavan Unsal, Narçin (Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2014)
Purvalanol and roscovitine are cyclin dependent kinase (CDK) inhibitors that induce cell cycle arrest and apoptosis in various cancer cells. We further hypothesized that co-treatment of CDK inhibitors with rapamycin, an ...
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CDK inhibitors-induced SSAT expression requires NF kappa B and PPAR gamma in MCF-7 breast cancer cells 

Obakan Yerlikaya, Pınar; Yıldırım, Şeyma; Öztürk, Mert Burak; Berrak, Özge; Çoker Gürkan, Ajda; Arısan, Elif Damla; Ünsal Palavan, Zeynep Narçın (TUBİTAK Scientific & Technical Research Council Turkey, Ataturk Bulvarı No 221, Kavaklıdere, Ankara, 00000, Turkey, 2015)
The cyclin-dependent kinase (CDK) inhibitors purvalanol and roscovitine are therapeutic agents that control cell proliferation through regulating cell-cycle machinery. They also affect polyamine (PA) metabolism, which is ...
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Polyamines modulate the roscovitine-induced cell death switch decision autophagy vs. apoptosis in MCF-7 and MDA-MB-231 breast cancer cells 

Arısan, Elif Damla; Akkoç, Yunus; Akyüz, Kaan Gencer; Kerman, Ezgi Melek; Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Palavan Ünsal, Zeynep Narçın (Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2015-06)
Current clinical strategies against breast cancer mainly involve the use of anti-hormonal agents to decrease estrogen production; however, development of resistance is a major problem. The resistance phenotype depends on ...

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AuthorArısan, Elif Damla (8)Çoker Gürkan, Ajda (8)Obakan Yerlikaya, Pınar (5)Palavan Ünsal, Zeynep Narçın (4)Obakan, Pınar (3)Palavan Unsal, Narçin (3)Özfiliz Kılbaş, Pelin (3)Berrak, Özge (2)Akkoç, Yunus (1)Akyüz, Kaan Gencer (1)... View MoreSubject
Roscovitine (8)
Apoptosis (7)Autophagy (7)Purvalanol (4)Phosphorylation (3)Polyamines (3)Bcl-2 (2)Breast cancer (2)Cervical cancer (2)Induced Apoptosis (2)... View MoreDate Issued2014 (3)2015 (3)2016 (1)2018 (1)Has File(s)No (7)Yes (1)

İstanbul Kültür University

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Istanbul Kültür University, Ataköy Campus E5 Karayolu Üzeri Bakırköy 34158, İstanbul / TURKEY
Copyright © İstanbul Kültür University

Creative Commons Lisansı
IKU Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Designed by  UNIREPOS