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Inhibition of PI3K signaling triggered apoptotic potential of curcumin which is hindered by Bcl-2 through activation of autophagy in MCF-7 cells 

Akkoç, Yunus; Berrak, Özge; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Palavan Ünsal, Zeynep Narçın (Elsevier France-Editions Scientifiques Medicales Elsevier, 23 Rue Linois, 75724 Paris, France, 2015-04)
Curcumin is a natural anti-cancer agent derived from turmeric (Curcuma longa). Curcumin triggers intrinsic apoptotic cell death by activating mitochondrial permeabilization due to the altered expression of pro-and ...
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Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells 

Obakan, Pınar; Arısan, Elif Damla; Özfiliz Kılbaş, Pelin; Çoker Gürkan, Ajda; Palavan Unsal, Narçin (Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands, 2014)
Purvalanol A is a specific CDK inhibitor which triggers apoptosis by causing cell cycle arrest in cancer cells. Although it has strong apoptotic potential, the mechanistic action of Purvalanol A on significant cell signaling ...
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DENSpm overcame Bcl-2 mediated resistance against Paclitaxel treatment in MCF-7 breast cancer cells via activating polyamine catabolic machinery 

Akyol, Zeynep; Çoker Gürkan, Ajda; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Palavan Ünsal, Zeynep Narçın (Elsevier France-Editions Scientifiques Medicales Elsevier, 23 Rue Linois, 75724 Paris, France, 2016-12)
Purpose: The Bcl-2 mediated resistance is one of the most critical obstacle in cancer therapy. Conventional chemotherapeutics such as Paclitaxel, a commonly used in the treatment of metastatic breast cancer, is not sufficient ...
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Bag-1 promotes cell survival through c-Myc-mediated ODC upregulation that is not preferred under apoptotic stimuli in MCF-7 cells 

Özfiliz Kılbaş, Pelin; Kızılboğa, Tuğba; Demir, Salih; Palavan Ünsal, Zeynep Narçın; Arısan, Elif Damla; Dinler Doğanay, Gizem (Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ USA, 2015-07)
Bag-1, Bcl-2 associated athanogene-1, is a multifunctional protein that can regulate a wide variety of cellular processes: proliferation, cell survival, transcription, apoptosis and motility. Bag-1 interacts with various ...
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Downregulation of c-Myc mediated ODC expression after purvalanol treatment is under control of upstream MAPK signaling axis in MCF-7 breast cancer cells 

Obakan, Pınar; Alkurt, Gizem; Köse, Betsi; Çoker Gürkan, Ajda; Arısan, Elif Damla; Coşkun, Deniz; Palavan Unsal, Narçin (Tubitak Scientific & Technical Research Council Turkey, Ataturk Bulvarı No 221, Kavaklıdere, Ankara, 00000, Turkey, 2014)
Roscovitine and purvalanol are specific cyclin-dependent kinase (CDK) inhibitors, which induce apoptosis by triggering cell cycle arrest in various cancer cells such as colon, prostate, and breast cancer cells. Although ...
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Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-kappa B signaling and polyamine metabolism in breast cancer cells 

Çoker Gürkan, Ajda; Çelik, Merve; Uğur, Merve; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Durdu, Zeynep Begüm; Ünsal Palavan, Zeynep Narçın (2018-08)
Curcumin is assumed to be a plant-derived therapeutic drug that triggers apoptotic cell death in vitro and in vivo by affecting different molecular targets such as NF-kappa B. Phase I/II trial of curcumin alone or with ...
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Polyamines modulate the roscovitine-induced cell death switch decision autophagy vs. apoptosis in MCF-7 and MDA-MB-231 breast cancer cells 

Arısan, Elif Damla; Akkoç, Yunus; Akyüz, Kaan Gencer; Kerman, Ezgi Melek; Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Palavan Ünsal, Zeynep Narçın (Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2015-06)
Current clinical strategies against breast cancer mainly involve the use of anti-hormonal agents to decrease estrogen production; however, development of resistance is a major problem. The resistance phenotype depends on ...

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AuthorArısan, Elif Damla (7)Çoker Gürkan, Ajda (6)Obakan Yerlikaya, Pınar (4)Palavan Ünsal, Zeynep Narçın (4)Akkoç, Yunus (2)Obakan, Pınar (2)Palavan Unsal, Narçin (2)Özfiliz Kılbaş, Pelin (2)Akyol, Zeynep (1)Akyüz, Kaan Gencer (1)... View MoreSubject
Breast cancer (7)
Apoptosis (6)Polyamines (3)c-Myc (2)Curcumin (2)Death (2)Paclitaxel (2)Polyamine (2)Roscovitine (2)Activated Protein-Kinase (1)... View MoreDate Issued2015 (3)2014 (2)2016 (1)2018 (1)Has File(s)No (6)Yes (1)

İstanbul Kültür University

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Istanbul Kültür University, Ataköy Campus E5 Karayolu Üzeri Bakırköy 34158, İstanbul / TURKEY
Copyright © İstanbul Kültür University

Creative Commons Lisansı
IKU Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Designed by  UNIREPOS