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Inhibition of autophagy by 3-MA potentiates purvalanol-induced apoptosis in Bax deficient HCT 116 colon cancer cells 

Çoker Gürkan, Ajda; Arısan, Elif Damla; Obakan, Pınar; Güvenir, Esin; Palavan Unsal, Narçin (Elsevier Inc, 525 B Street, Ste 1900, San Diego, Ca 92101-4495 Usa, 2014-10-15)
The purine-derived analogs, roscovitine and purvalanol are selective synthetic inhibitors of cyclin-dependent kinases (CDKs) induced cell cycle arrest and lead to apoptotic cell death in various cancer cells. Although a ...
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Roscovitine-treated He La cells finalize autophagy later than apoptosis by downregulating Bcl-2 

Çoker Gürkan, Ajda; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Özfiliz Kılbaş, Pelin; Köse, Betsi; Bıçkıcı, Güven; Palavan Ünsal, Zeynep Narçın (Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2015-03)
The cell cycle is tightly regulated by the family of cyclin-dependent kinases (CDKs). CDKs act as regulatory factors on serine and threonine residues by phosphorylating their substrates and cyclins. CDK-targeting drugs ...
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Inhibition of PI3K signaling triggered apoptotic potential of curcumin which is hindered by Bcl-2 through activation of autophagy in MCF-7 cells 

Akkoç, Yunus; Berrak, Özge; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Palavan Ünsal, Zeynep Narçın (Elsevier France-Editions Scientifiques Medicales Elsevier, 23 Rue Linois, 75724 Paris, France, 2015-04)
Curcumin is a natural anti-cancer agent derived from turmeric (Curcuma longa). Curcumin triggers intrinsic apoptotic cell death by activating mitochondrial permeabilization due to the altered expression of pro-and ...
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Diclofenac induced apoptosis via altering PI3K/Akt/MAPK signaling axis in HCT 116 more efficiently compared to SW480 colon cancer cells 

Arısan, Elif Damla; Ergül, Zehragül; Bozdağ, Gülnihal; Rencüzoğulları, Özge; Çoker Gürkan, Ajda; Obakan Yerlikaya, Pınar; Coşkun, Deniz; Ünsal, Zeynep Narçin (Springer Link, 2018-12)
Diclofenac is a preferential cyclooxygenase 2 inhibitor (COX-2) and member of non-steroidal anti-inflammatory drugs (NSAIDs). Inflammation is one of the main reason of poor prognosis of colon cancer cases; thereby NSAIDs ...
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mTOR is a fine tuning molecule in CDK inhibitors-induced distinct cell death mechanisms via PI3K/AKT/mTOR signaling axis in prostate cancer cells 

Berrak, Özge; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Palavan Ünsal, Zeynep Narçın (Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands, 2016-10)
Purvalanol and roscovitine are cyclin dependent kinase (CDK) inhibitors that induce cell cycle arrest and apoptosis in various cancer cells. We further hypothesized that co-treatment of CDK inhibitors with rapamycin, an ...
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Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells 

Obakan, Pınar; Arısan, Elif Damla; Özfiliz Kılbaş, Pelin; Çoker Gürkan, Ajda; Palavan Unsal, Narçin (Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands, 2014)
Purvalanol A is a specific CDK inhibitor which triggers apoptosis by causing cell cycle arrest in cancer cells. Although it has strong apoptotic potential, the mechanistic action of Purvalanol A on significant cell signaling ...
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Lack of functional p53 renders DENSpm-induced autophagy and apoptosis in time dependent manner in colon cancer cells 

Çoker Gürkan, Ajda; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Palavan Ünsal, Zeynep Narçın (Springer Wien, Sachsenplatz 4-6, Po Box 89, A-1201 Wien, Austria, 2015-01)
Polyamines (PAs), such as putrescine, spermidine and spermine, are alkyl-amines that are essential for cell growth, proliferation, differentiation and cancer progression in eukaryotic cells. A designed PA analogue; DENSpm, ...
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Cyclin-dependent kinase inhibitors, roscovitine and purvalanol, induce apoptosis and autophagy related to unfolded protein response in HeLa cervical cancer cells 

Özfiliz Kılbaş, Pelin; Sarıkaya, Bahar; Obakan Yerlikaya, Pınar; Çoker Gürkan, Ajda; Arısan, Elif Damla; Temizci, Benan; Palavan Ünsal, Zeynep Narçın (Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands, 2018-10)
Roscovitine (Rosc) and purvalanol (Pur) are competitive inhibitors of cyclin-dependent kinases (CDKs) by targeting their ATP-binding pockets. Both drugs are shown to be effective to decrease cell viability and dysregulate ...
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DENSpm overcame Bcl-2 mediated resistance against Paclitaxel treatment in MCF-7 breast cancer cells via activating polyamine catabolic machinery 

Akyol, Zeynep; Çoker Gürkan, Ajda; Arısan, Elif Damla; Obakan Yerlikaya, Pınar; Palavan Ünsal, Zeynep Narçın (Elsevier France-Editions Scientifiques Medicales Elsevier, 23 Rue Linois, 75724 Paris, France, 2016-12)
Purpose: The Bcl-2 mediated resistance is one of the most critical obstacle in cancer therapy. Conventional chemotherapeutics such as Paclitaxel, a commonly used in the treatment of metastatic breast cancer, is not sufficient ...
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mTOR signalling alters cell fate following inhibition of cyclin-dependent kinases due to androgen receptor status in prostate cancer cells 

Arısan, Elif Damla; Berrak, Ozge; Obakan, Pınar; Çoker Gürkan, Ajda; Palavan Unsal, Narçin (Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2014)
Purvalanol and roscovitine are cyclin dependent kinase (CDK) inhibitors that induce cell cycle arrest and apoptosis in various cancer cells. We further hypothesized that co-treatment of CDK inhibitors with rapamycin, an ...
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AuthorArısan, Elif Damla (19)Çoker Gürkan, Ajda (17)Obakan Yerlikaya, Pınar (12)Palavan Ünsal, Zeynep Narçın (9)Özfiliz Kılbaş, Pelin (6)Obakan, Pınar (5)Palavan Unsal, Narçin (5)Dinler Doğanay, Gizem (3)Akkoç, Yunus (2)Berrak, Özge (2)... View MoreSubject
Apoptosis (20)
Autophagy (9)Roscovitine (7)Breast cancer (6)Colon cancer (5)Polyamines (5)Purvalanol (4)Bcl-2 (3)Death (3)DENSpm (3)... View MoreDate Issued2015 (7)2014 (5)2018 (4)2016 (2)2019 (2)Has File(s)No (19)Yes (1)

İstanbul Kültür University

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Istanbul Kültür University, Ataköy Campus E5 Karayolu Üzeri Bakırköy 34158, İstanbul / TURKEY
Copyright © İstanbul Kültür University

Creative Commons Lisansı
IKU Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Designed by  UNIREPOS