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Inhibition of autophagy by 3-MA potentiates purvalanol-induced apoptosis in Bax deficient HCT 116 colon cancer cells 

Çoker Gürkan, Ajda; Arısan, Elif Damla; Obakan, Pınar; Güvenir, Esin; Palavan Unsal, Narçin (Elsevier Inc, 525 B Street, Ste 1900, San Diego, Ca 92101-4495 Usa, 2014-10-15)
The purine-derived analogs, roscovitine and purvalanol are selective synthetic inhibitors of cyclin-dependent kinases (CDKs) induced cell cycle arrest and lead to apoptotic cell death in various cancer cells. Although a ...
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CDK Inhibitors Induce Mitochondria-mediated Apoptosis Through the Activation of Polyamine Catabolic Pathway in LNCaP, DU145 and PC3 Prostate Cancer Cells 

Arısan, Elif Damla; Obakan, Pınar; Çoker Gürkan, Ajda; Calcabrini, Annarica; Agostinelli, Enzo; Palavan Unsal, Narçin (Bentham Science Publ Ltd, Executive Ste Y-2, Po Box 7917, Saif Zone, 1200 Br Sharjah, U Arab Emirates, 2014-01)
Androgen signaling is critical in prostate cancer development and progression. The co-existence of hormone responsive and irresponsive cells due to functional androgen receptor (AR) in prostate gland is the major obstacle ...
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Epibrassinolide-induced apoptosis regardless of p53 expression via activating polyamine catabolic machinery, a common target for androgen sensitive and insensitive prostate cancer cells 

Obakan, Pınar; Arısan, Elif Damla; Çoker Gürkan, Ajda; Palavan Unsal, Narçin (Wiley-Blackwell, 111 River St, Hoboken 07030-5774, Nj Usa, 2014-12)
BACKGROUNDEpibrassinolide (EBR), is a member of the brassinosteroids (BR), has been shown as an apoptotic inducer in different cancer cell lines. We previously showed that EBR induced apoptosis by activating polyamine ...
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Association between IL-1RN VNTR, IL-1 beta -511 and IL-6 (-174, -572, -597) Gene Polymorphisms and Urolithiasis 

Çoker Gürkan, Ajda; Arısan, Elif Damla; Palavan Unsal, Narçin; Arısan, Serdar; Sonmez, Nurettin Cem (Karger, Allschwilerstrasse 10, Ch-4009 Basel, Switzerland, 2013)
Urolithiasis is a common multifactorial urological disorder that is characterized by stone formation. Interleukin (IL)-1 and IL-6 are pro-inflammatory cytokines that might be linked with urolithiasis. The single nucleotide ...
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Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells 

Obakan, Pınar; Arısan, Elif Damla; Özfiliz Kılbaş, Pelin; Çoker Gürkan, Ajda; Palavan Unsal, Narçin (Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands, 2014)
Purvalanol A is a specific CDK inhibitor which triggers apoptosis by causing cell cycle arrest in cancer cells. Although it has strong apoptotic potential, the mechanistic action of Purvalanol A on significant cell signaling ...
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mTOR signalling alters cell fate following inhibition of cyclin-dependent kinases due to androgen receptor status in prostate cancer cells 

Arısan, Elif Damla; Berrak, Ozge; Obakan, Pınar; Çoker Gürkan, Ajda; Palavan Unsal, Narçin (Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2014)
Purvalanol and roscovitine are cyclin dependent kinase (CDK) inhibitors that induce cell cycle arrest and apoptosis in various cancer cells. We further hypothesized that co-treatment of CDK inhibitors with rapamycin, an ...
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Downregulation of c-Myc mediated ODC expression after purvalanol treatment is under control of upstream MAPK signaling axis in MCF-7 breast cancer cells 

Obakan, Pınar; Alkurt, Gizem; Köse, Betsi; Çoker Gürkan, Ajda; Arısan, Elif Damla; Coşkun, Deniz; Palavan Unsal, Narçin (Tubitak Scientific & Technical Research Council Turkey, Ataturk Bulvarı No 221, Kavaklıdere, Ankara, 00000, Turkey, 2014)
Roscovitine and purvalanol are specific cyclin-dependent kinase (CDK) inhibitors, which induce apoptosis by triggering cell cycle arrest in various cancer cells such as colon, prostate, and breast cancer cells. Although ...
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Bag-1L is a Stress-withstand Molecule Prevents the Downregulation of Mcl-1 and c-Raf Under Control of Heat Shock Proteins in Cisplatin Treated HeLa Cervix Cancer Cells 

Özfiliz Kılbaş, Pelin; Arısan, Elif Damla; Çoker Gürkan, Ajda; Obakan, Pınar; Eralp, Tuğçe Nur; Dinler Doğanay, Gizem; Palavan Unsal, Narçin (Asian Pacific Organization Cancer Prevention, Apjcp Head Office, Korean Natl Cancer Center, 323 Ilan -Ro, Ilsandong-Gu, Goyang-Si, Gyeonggi-Do, 410-769, South Korea, 2014)
Background: Cisplatin, a DNA damaging agent, induces apoptosis through increasing DNA fragmentation. However, identification of intrinsic resistance molecules against Cisplatin is vital to estimate the success of therapy. ...
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Activation of polyamine catabolic enzymes involved in diverse responses against epibrassinolide-induced apoptosis in LNCaP and DU145 prostate cancer cell lines 

Obakan, Pınar; Arısan, Elif Damla; Palavan Unsal, Narçin; Calcabrini, Annarica; Agostinelli, Enzo; Bolkent, Şehnaz (Springer Wien, Sachsenplatz 4-6, Po Box 89, A-1201 Wien, Austria, 2014-03)
Epibrassinolide (EBR) is a biologically active compound of the brassinosteroids, steroid-derived plant growth regulator family. Generally, brassinosteroids are known for their cell expansion and cell division-promoting ...

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AuthorArısan, Elif Damla (9)
Palavan Unsal, Narçin (9)
Obakan, Pınar (8)Çoker Gürkan, Ajda (8)Agostinelli, Enzo (2)Calcabrini, Annarica (2)Özfiliz Kılbaş, Pelin (2)Alkurt, Gizem (1)Arısan, Serdar (1)Berrak, Ozge (1)... View MoreSubjectApoptosis (5)apoptosis (3)Polyamines (3)Roscovitine (3)Autophagy (2)Bax (2)Bcl-2 (2)Breast cancer (2)CDK inhibitors (2)Cyclin-Dependent Kinases (2)... View MoreDate Issued2014 (8)2013 (1)Has File(s)No (6)Yes (3)

İstanbul Kültür University

Hakkında |Politika | Kütüphane | İletişim | Send Feedback | Admin

Istanbul Kültür University, Ataköy Campus E5 Karayolu Üzeri Bakırköy 34158, İstanbul / TURKEY
Copyright © İstanbul Kültür University

Creative Commons Lisansı
IKU Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Designed by  UNIREPOS