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Purvalanol induces endoplasmic reticulum stress-mediated apoptosis and autophagy in a time-dependent manner in HCT116 colon cancer cells
(Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2015-06)
Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. Various ...
Cytokine network is critical in growth hormone-induced resistance mechanism against curcumin which modulates JAK/STAT/SOCS pathway in MDA-MB-231 and MCF-7 breast cancer cells
(Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ USA, 2016-09)
Growth hormone mediated resistance against curcumin induced-apoptosis via modulating of JAK/STAT/SOCS pathway and inflammatory cytokines in MDA-MB-453 breast cancer cells
(Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ USA, 2016-09)
The inhibition of PI3K and NF kappa B promoted curcumin-induced cell cycle arrest at G2/M via altering polyamine metabolism in Bcl-2 overexpressing MCF-7 breast cancer cells
(Elsevier France-Editions Scientifiques Medicales Elsevier, 23 Rue Linois, 75724 Paris, France, 2016-02)
Bcl-2 protein has been contributed with number of genes which are involved in oncogenesis. Among the many targets of Bcl-2, NF kappa B have potential role in induction of cell cycle arrest. Curcumin has potential therapeutic ...
Endoplasmic reticulum stress is activated after epibrassinolide treatment leading autophagy in wild type and Atg5-/- mouse embryonic fibroblasts: a survival mechanism in nonmalignant cells
(Wiley, 111 River St, Hoboken 07030-5774, NJ USA, 2017-09)
Inhibition of PI3K signaling triggered apoptotic potential of curcumin which is hindered by Bcl-2 through activation of autophagy in MCF-7 cells
(Elsevier France-Editions Scientifiques Medicales Elsevier, 23 Rue Linois, 75724 Paris, France, 2015-04)
Curcumin is a natural anti-cancer agent derived from turmeric (Curcuma longa). Curcumin triggers intrinsic apoptotic cell death by activating mitochondrial permeabilization due to the altered expression of pro-and ...
Roscovitine-treated He La cells finalize autophagy later than apoptosis by downregulating Bcl-2
(Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2015-03)
The cell cycle is tightly regulated by the family of cyclin-dependent kinases (CDKs). CDKs act as regulatory factors on serine and threonine residues by phosphorylating their substrates and cyclins. CDK-targeting drugs ...
Curcumin induced-apoptotic cell death in GH overexpressed MDA-MB-231 breast cancer in time dependent manner
(Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ USA, 2015-07)
EBR promotes p53 independent apoptosis in colon carcinoma cell lines
(Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ USA, 2015-07)
Lack of functional p53 renders DENSpm-induced autophagy and apoptosis in time dependent manner in colon cancer cells
(Springer Wien, Sachsenplatz 4-6, Po Box 89, A-1201 Wien, Austria, 2015-01)
Polyamines (PAs), such as putrescine, spermidine and spermine, are alkyl-amines that are essential for cell growth, proliferation, differentiation and cancer progression in eukaryotic cells. A designed PA analogue; DENSpm, ...