Browsing Makaleler / Articles by Title
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Activation of polyamine catabolic enzymes involved in diverse responses against epibrassinolide-induced apoptosis in LNCaP and DU145 prostate cancer cell lines
(Springer Wien, Sachsenplatz 4-6, Po Box 89, A-1201 Wien, Austria, 2014-03)Epibrassinolide (EBR) is a biologically active compound of the brassinosteroids, steroid-derived plant growth regulator family. Generally, brassinosteroids are known for their cell expansion and cell division-promoting ... -
Aging-related diseases and autophagy
(2016)Autophagy is fundamental, evolutionary conserved physiological process at molecular level which targets long-lived cytosolic proteins and organelles to be recycled through lysosomal degradation. Diminished autophagic ... -
Anti-metastatic effect of ranolazine in an in vivo rat model of prostate cancer, and expression of voltage-gated sodium channel protein in human prostate
(2019-03-20)Background Voltage-gated Na+ channels (VGSCs) are functionally upregulated in rat and human prostate cancer (PCa) where channel activity promotes cellular invasiveness in vitro and metastasis in vivo. Ranolazine is a ... -
Antioxidative defense system differences to drought stress of tomato cultivars
(Elsevier Science Bv, Po Box 211, 1000 Ae Amsterdam, Netherlands, 2014-09)The aim of this study is to investigate the enzymatic and non-enzymatic responses of two different industrial tomato varieties (X5671R and 5MX12956) against drought stress. Fourteen-day-old seedlings were subjected to ... -
Applications of Ionizing Radiation in Mutation Breeding
(InTech, 2017-05)As a predicted result of increasing population worldwide, improvements in the breeding strategies in agriculture are valued as mandatory. The natural resources are limited, and due to the natural disasters like sudden ... -
Assessment of Interleukin-1 Gene Cluster Polymorphisms in Lone Atrial Fibrillation: New Insight into the Role of Inflammation in Atrial Fibrillation
(Wiley-Blackwell, 111 River St, Hoboken 07030-5774, Nj USA, 2013-10)BackgroundSystemic inflammation is accepted as one of the pathophysiological mechanisms of atrial fibrillation (AF). The role of inflammation has been shown previously. Interleukin (IL) system is the main modulator of the ... -
Association between IL-1RN VNTR, IL-1 beta -511 and IL-6 (-174, -572, -597) Gene Polymorphisms and Urolithiasis
(Karger, Allschwilerstrasse 10, Ch-4009 Basel, Switzerland, 2013)Urolithiasis is a common multifactorial urological disorder that is characterized by stone formation. Interleukin (IL)-1 and IL-6 are pro-inflammatory cytokines that might be linked with urolithiasis. The single nucleotide ... -
Association Between Sporadic Parkinson Disease And Interleukin-1 Beta-511 Gene Polymorphisms In The Turkish Population
(John Libbey Eurotext Ltd, 127 Ave De La Republique, 92120 Montrouge, France, 2010-06)The pathogenesis of Parkinson Disease (PD) remains poorly understood; however, inflammation is thought to play an important role in disease progression. Recent reports suggest that IL-1, a major proinflammatory cytokine, ... -
Atiprimod induce apoptosis in pituitary adenoma: Endoplasmic reticulum stress and autophagy pathways
(WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2019-12)Pituitary adenoma is the most common tumor with a high recurrence rate due to a hormone-dependent JAK/signal transducer and activator of transcriptions (STAT) signaling. Atiprimod, a novel compound belonging to the azaspirane ... -
Bag-1 promotes cell survival through c-Myc-mediated ODC upregulation that is not preferred under apoptotic stimuli in MCF-7 cells
(Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ USA, 2015-07)Bag-1, Bcl-2 associated athanogene-1, is a multifunctional protein that can regulate a wide variety of cellular processes: proliferation, cell survival, transcription, apoptosis and motility. Bag-1 interacts with various ... -
Bag-1 silencing enhanced apoptosis via altering the ubiquitination process of Foxo3a in MCP-7 breast cancer cells
(Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2017) -
Bag-1 Silencing Enhanced Chemotherapeutic Drug-induced Apoptosis in MCF-7 Breast Cancer Cells Affecting PI3K/Akt/mTOR and MAPK Signaling Pathways
(2019-01-19)The multifunctional anti-apoptotic Bag-1 protein has important roles in apoptosis, proteasome-mediated degradation, transcriptional regulation, and intracellular signaling. Bag-1 promotes cell survival and proliferation, ... -
Bag-1L is a Stress-withstand Molecule Prevents the Downregulation of Mcl-1 and c-Raf Under Control of Heat Shock Proteins in Cisplatin Treated HeLa Cervix Cancer Cells
(Asian Pacific Organization Cancer Prevention, Apjcp Head Office, Korean Natl Cancer Center, 323 Ilan -Ro, Ilsandong-Gu, Goyang-Si, Gyeonggi-Do, 410-769, South Korea, 2014)Background: Cisplatin, a DNA damaging agent, induces apoptosis through increasing DNA fragmentation. However, identification of intrinsic resistance molecules against Cisplatin is vital to estimate the success of therapy. ... -
Bag-1L mediated chemoresistance mechanism through preventing downregulation of Mcl-1 and c-Raf by heat shock proteins in HeLa cells
(2014-11)Background: Cisplatin, a DNA damaging agent, induces apoptosis through increasing DNA fragmentation. However, identification of intrinsic resistance molecules against Cisplatin is vital to estimate the success of ... -
Biological responses of ultrafine grained pure titanium and their sand blasted surfaces
(Elsevier Science Bv, Po Box 211, 1000 Ae Amsterdam, Netherlands, 2018-10-01)The use of materials as implants has become vital for determining optimal product design to enhance the needs of usage and longevity in body. Ultrafine grained pure titanium offers advanced mechanical properties for medical ... -
Calpain inhibitor AK 295 inhibits calpain-induced apoptosis and improves neurologic function after traumatic spinal cord injury in rats
(Soc Espanola Neurocirugia, C/O Dr Poza, Gran Via Salzillo 42, 30005 Murcia, Spain, 2009-06)Background. An increase in the level of intracellular calcium activates the calcium-dependent neutral protease calpain, which in turn leads to cellular dysfunction and cell death after an insult to the central nervous ... -
Calreticulin is a fine tuning molecule in epibrassinolide-induced apoptosis through activating endoplasmic reticulum stress in colon cancer cells
(Wiley, 111 River St, Hoboken 07030-5774, NJ USA, 2017-06)Epibrassinolide (EBR), a member of brassinostreoids plant hormones with cell proliferation promoting role in plants, is a natural polyhydroxysteroid with structural similarity to steroid hormones of vertebrates. EBR has ... -
Cathepsin K analysis in a pycnodysostosis cohort: demographic, genotypic and phenotypic features
(Biomed Central Ltd, 236 Grays Inn Rd, Floor 6, London Wc1X 8Hl, England, 2014-04-26)Background: To characterize cathepsin K (CTSK) mutations in a group of patients with pycnodysostosis, who presented with either short stature or atypical fractures to pediatric endocrinology or dysmorphic features to ... -
CDK Inhibitors Induce Mitochondria-mediated Apoptosis Through the Activation of Polyamine Catabolic Pathway in LNCaP, DU145 and PC3 Prostate Cancer Cells
(Bentham Science Publ Ltd, Executive Ste Y-2, Po Box 7917, Saif Zone, 1200 Br Sharjah, U Arab Emirates, 2014-01)Androgen signaling is critical in prostate cancer development and progression. The co-existence of hormone responsive and irresponsive cells due to functional androgen receptor (AR) in prostate gland is the major obstacle ... -
CDK inhibitors-induced SSAT expression requires NF kappa B and PPAR gamma in MCF-7 breast cancer cells
(TUBİTAK Scientific & Technical Research Council Turkey, Ataturk Bulvarı No 221, Kavaklıdere, Ankara, 00000, Turkey, 2015)The cyclin-dependent kinase (CDK) inhibitors purvalanol and roscovitine are therapeutic agents that control cell proliferation through regulating cell-cycle machinery. They also affect polyamine (PA) metabolism, which is ...
