Browsing Makaleler / Articles by Title
Now showing items 16-35 of 140
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Calpain inhibitor AK 295 inhibits calpain-induced apoptosis and improves neurologic function after traumatic spinal cord injury in rats
(Soc Espanola Neurocirugia, C/O Dr Poza, Gran Via Salzillo 42, 30005 Murcia, Spain, 2009-06)Background. An increase in the level of intracellular calcium activates the calcium-dependent neutral protease calpain, which in turn leads to cellular dysfunction and cell death after an insult to the central nervous ... -
Calreticulin is a fine tuning molecule in epibrassinolide-induced apoptosis through activating endoplasmic reticulum stress in colon cancer cells
(Wiley, 111 River St, Hoboken 07030-5774, NJ USA, 2017-06)Epibrassinolide (EBR), a member of brassinostreoids plant hormones with cell proliferation promoting role in plants, is a natural polyhydroxysteroid with structural similarity to steroid hormones of vertebrates. EBR has ... -
Cathepsin K analysis in a pycnodysostosis cohort: demographic, genotypic and phenotypic features
(Biomed Central Ltd, 236 Grays Inn Rd, Floor 6, London Wc1X 8Hl, England, 2014-04-26)Background: To characterize cathepsin K (CTSK) mutations in a group of patients with pycnodysostosis, who presented with either short stature or atypical fractures to pediatric endocrinology or dysmorphic features to ... -
CDK Inhibitors Induce Mitochondria-mediated Apoptosis Through the Activation of Polyamine Catabolic Pathway in LNCaP, DU145 and PC3 Prostate Cancer Cells
(Bentham Science Publ Ltd, Executive Ste Y-2, Po Box 7917, Saif Zone, 1200 Br Sharjah, U Arab Emirates, 2014-01)Androgen signaling is critical in prostate cancer development and progression. The co-existence of hormone responsive and irresponsive cells due to functional androgen receptor (AR) in prostate gland is the major obstacle ... -
CDK inhibitors-induced SSAT expression requires NF kappa B and PPAR gamma in MCF-7 breast cancer cells
(TUBİTAK Scientific & Technical Research Council Turkey, Ataturk Bulvarı No 221, Kavaklıdere, Ankara, 00000, Turkey, 2015)The cyclin-dependent kinase (CDK) inhibitors purvalanol and roscovitine are therapeutic agents that control cell proliferation through regulating cell-cycle machinery. They also affect polyamine (PA) metabolism, which is ... -
Characterization of GH-1 Mutations in Children with Isolated Growth Hormone Deficiency in the Turkish Population
(FREUND PUBLISHING HOUSE LTD, PO BOX 35010, TEL AVIV 61350, ISRAEL, 2009-10)Isolated growth hormone deficiency (IGHD) is defined as a medical condition associated with growth failure due to insufficient production of growth hormone (GH) or lack of growth hormone action. It occurs with an incidence ... -
Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation
(Oxford University Press, 2009-09-01)Increased expression of antiapoptotic Bcl-2 proteins confers therapeutic resistance in various cancer types. Targeting Bcl-2 proteins by small molecules or activating alternative pathways to bypass Bcl-2-mediated protection ... -
Comparative transcriptional profiling of soybean orthologs of arabidopsis trichome developmental genes under salt stress
(Springer, 233 Spring St, New York, Ny 10013 USA, 2018-02)The aim of this study was to determine the ultrastructural changes and regulation of trichome-metabolism-related genes against salt stress in soybean (Glycine max L. Merr.) plants. The 14-day-old Ataem-7 and S04-05 soybean ... -
Comparison of the effects of meta-topolin and other cytokinins on chlorophyll and protein contents and peroxidase activity in cucumber cotyledons
(Taylor and Francis Online, 2003)Cytokinins play an important role in controlling many of the processes that contribute to plant senescence. The aim of this study was to compare the effect of different cytokinins, especially the new aromatic cytokinin ... -
Curcumin induced-apoptotic cell death in GH overexpressed MDA-MB-231 breast cancer in time dependent manner
(Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ USA, 2015-07) -
Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-kappa B signaling and polyamine metabolism in breast cancer cells
(2018-08)Curcumin is assumed to be a plant-derived therapeutic drug that triggers apoptotic cell death in vitro and in vivo by affecting different molecular targets such as NF-kappa B. Phase I/II trial of curcumin alone or with ... -
Curcumin Prevented Human Autocrine Growth Hormone (GH) Signaling Mediated NF-κB Activation and miR-183-96-182 Cluster Stimulated Epithelial Mesenchymal Transition in T47D Breast Cancer Cells
(2019-02)Autocrine growth hormone (GH) signaling is a promoting factor for breast cancer via triggering abnormal cell growth, proliferation, and metastasis, drug resistance. Curcumin (diferuloylmethane), a polyphenol derived from ... -
Cyclin-dependent kinase inhibitors, roscovitine and purvalanol, induce apoptosis and autophagy related to unfolded protein response in HeLa cervical cancer cells
(Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands, 2018-10)Roscovitine (Rosc) and purvalanol (Pur) are competitive inhibitors of cyclin-dependent kinases (CDKs) by targeting their ATP-binding pockets. Both drugs are shown to be effective to decrease cell viability and dysregulate ... -
Cytogenetic biomonitoring of primary school children exposed to air pollutants: micronuclei analysis of buccal epithelial cells
(Springer Heidelberg, Tiergartenstrasse 17, D-69121 Heidelberg, Germany, 2014-01)There is an increasing attempt in the world to determine the exposures of children to environmental chemicals. To analyze the genotoxic effect of air pollution, micronucleus (MN) assay was carried out in buccal epithelial ... -
Cytokine network is critical in growth hormone-induced resistance mechanism against curcumin which modulates JAK/STAT/SOCS pathway in MDA-MB-231 and MCF-7 breast cancer cells
(Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ USA, 2016-09) -
DENSpm overcame Bcl-2 mediated resistance against Paclitaxel treatment in MCF-7 breast cancer cells via activating polyamine catabolic machinery
(Elsevier France-Editions Scientifiques Medicales Elsevier, 23 Rue Linois, 75724 Paris, France, 2016-12)Purpose: The Bcl-2 mediated resistance is one of the most critical obstacle in cancer therapy. Conventional chemotherapeutics such as Paclitaxel, a commonly used in the treatment of metastatic breast cancer, is not sufficient ... -
Diclofenac induced apoptosis via altering PI3K/Akt/MAPK signaling axis in HCT 116 more efficiently compared to SW480 colon cancer cells
(Springer Link, 2018-12)Diclofenac is a preferential cyclooxygenase 2 inhibitor (COX-2) and member of non-steroidal anti-inflammatory drugs (NSAIDs). Inflammation is one of the main reason of poor prognosis of colon cancer cases; thereby NSAIDs ... -
Distribution of peroxidase activity and polyamine pattern of Heliotropium europeum in potassium deficiency conditions
(INDERSCIENCE ENTERPRISES LTD, WORLD TRADE CENTER BLDG, 29 ROUTE DE PRE-BOIS, CASE POSTALE 896, CH-1215 GENEVA, SWITZERLAND, 2007)Polyamines, especially putrescine, are reported to increase in higher plants in response to various stressors, in particular mineral deficiency, low pH and different atmospheric pollutants. Peroxidases are another stress ... -
Downregulation of c-Myc mediated ODC expression after purvalanol treatment is under control of upstream MAPK signaling axis in MCF-7 breast cancer cells
(Tubitak Scientific & Technical Research Council Turkey, Ataturk Bulvarı No 221, Kavaklıdere, Ankara, 00000, Turkey, 2014)Roscovitine and purvalanol are specific cyclin-dependent kinase (CDK) inhibitors, which induce apoptosis by triggering cell cycle arrest in various cancer cells such as colon, prostate, and breast cancer cells. Although ...
