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Browsing Akademik Merkezler / Academic Centers by Subject "Aging"

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    A review of alpha activity in integrative brain function: Fundamental physiology, Sensory coding, cognition and pathology
    (Elsevier Science Bv, Po Box 211, 1000 Ae Amsterdam, Netherlands, 2012-10) BAŞAR, EROL; TR142226
    Aim of the review: Questions related to the genesis and functional correlates of the brain's alpha oscillations around 10 Hz (Alpha) are one of the fundamental research areas in neuroscience. In recent decades, analysis of this activity has been not only the focus of interest for description of sensory-cognitive processes, but has also led to trials for establishing new hypotheses. The present review and the companion review aim to constitute an ensemble of "reasonings and suggestions" to understand alpha oscillations based on a wide range of accumulated findings rather than a trial to launch a new "alpha theory". Surveyed descriptions related to physiology and brain function: The review starts with descriptions of earlier extracellular recordings, field potentials and also considers earlier alpha hypotheses. Analytical descriptions of evoked and event-related responses, event-related desynchronization, the relationship between spontaneous activity and evoked potentials, aging brain, pathology and alpha response in cognitive impairment are in the content of this review. In essence, the gamut of the survey includes a multiplicity of evidence on functional correlates in sensory processing, cognition, memory and vegetative system, including the spinal cord and heart. (C) 2012 Elsevier B.V. All rights reserved.
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    Association Of Peripheral Visfatin Levels And Visfatin G-948T Gene Polymorphism With Alzheimer's Disease In A Turkish Population
    (Güneş Kitabevi Ltd Sti, M Rauf Inan Sok No 3, Ankara, Sıhhıye 06410, Turkey, 2013) Vurgun, Ufuk; Şahin, Özlem; Tüfekçi, Kemal Uğur; Keskinoğlu, Pembe; Yener, Görsev; Genç, Kemal Kürşad; Genç, Sermin; 167754; 190994; 143760; 166828; 2453
    Introduction: Visfatin is a pleiotropic cytokine implicated in several physiological and pathophysiological processes such as innate immunity, cellular metabolism, longevity, and inflammation. Altered visfatin levels and visfatin gene polymorphisms have been reported in various human diseases, including type 2 diabetes mellitus, rheumatoid arthritis, obesity, coronary artery disease and stroke.. Materials and Method: In this study, we investigated whether serum visfatin levels were changed in volunteers with Alzheimer's disease (AD) (n = 40) or healthy controls (n=40) and whether visfatin gene G-948T polymorphism was associated with the disease. Results: Visfatin levels were not significantly different in AD patients compared with healthy aged control subjects. In this relatively small population, we found a significant, but weak association between GT heterozygous genotype at position -948 of visfatin gene and AD. However, there was no association between G-948T polymorphism and visfatin levels, and any demographic, anthropometric or biochemical parameters. Conclusion: Further studies in larger and different populations are needed to fully elaborate the involvement of visfatin gene in AD.
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    Decrease of delta oscillatory responses is associated with increased age in healthy elderly
    (Elsevier Science Bv, Po Box 211, 1000 AE Amsterdam, Netherlands, 2016-05) Emek Savaş, Derya Durusu; Güntekin, Bahar; Yener, Görsev G.; BAŞAR, EROL; 204666; 143760; 142226
    Background: The purpose of this study was to investigate changes in delta event-related oscillations (EROs) in younger and older healthy elderly subjects. We hypothesized that delta EROs were affected by age-related changes, which could be reflected in a visual oddball paradigm. Method: The study included two groups of subjects, 17 younger healthy elderly (mean age: 63.1 +/- 2.8 years) and 17 gender- and education-matched older healthy elderly (mean age: 79.6 +/- 5.2 years), who performed a visual oddball paradigm. EEG was recorded from F-3, F-z, F-4, C-3, C-z, C-4, P-3, P-z, P-4, O-1, O-z and O-2 locations. Peak-to-peak amplitudes of delta (0.5-3 Hz) target ERO responses during the post-stimulus 0-800 ms time window were measured. Repeated measures of ANOVA was used to analyze four locations (frontal, central, parietal, occipital), at three sagittal (left, midline, right) sites. Independent t-tests were applied for post-hoc analyses. Results: The older healthy elderly group had 16-25% lower values for the maximum peak-to-peak amplitudes of delta ERO compared with the younger healthy elderly group over frontal (p < 0.003), central (p < 0.0001) and parietal (p < 0.007) locations [F-3.95 = 4396, p = 0.015] Furthermore, there was a moderate negative correlation between age and C-z peak-to-peak amplitude of target delta responses [r = -0.401, p < 0.02], indicating the notion that peak-to-peak amplitude of C-z decreases as age increases. Conclusion: In the present study younger healthy elderly showed significantly higher event-related delta responses than older healthy elderly at frontal, central and parietal locations. Moreover, delta ERO responses decreased in accordance with age. (C) 2015 Elsevier B.V. All rights reserved.