Scopus İndeksli Yayınlar / Scopus Indexed Publications

Permanent URI for this collectionhttps://hdl.handle.net/11413/6358

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4-Hydroxyquinolin-2(1H)-One Isolated in Cryogenic Argon and Xenon Matrices: Tautomers and Photochemistry
(Elsevier, 2024) Secrieru, A.; Lopes, S.; Nikitin, T.; Cristiano, Maria L. S.; FAUSTO, RUI
4-Hydroxyquinolin-2(1H)-one (4HQ2O) was synthesized, isolated in cryogenic matrices (argon and xenon), and studied by infrared spectroscopy. Quantum chemical calculations carried out at the DFT(B3LYP)/6-311++G (3df,3pd) level of theory were used to determine the conformational and tautomeric properties of the molecule. Two tautomeric forms were identified in the as-deposited matrices with the help of the theoretical data. To investigate the photochemistry of the compound, in situ broadband ultraviolet (lambda > 283 nm) irradiation of the asdeposited argon matrix was performed. This irradiation led to the generation of an additional tautomer, together with the products of fragmentation of the heterocyclic ring of the molecule, specifically isocyanic acid and carbon monoxide. Photoproducts such as 1,3-dihydro-2H-indol-2-one and cyclohepta-1,2,4,6-tetraene were also observed in the photolyzed argon matrix. A comprehensive assignment of the infrared spectra of all the species observed experimentally is presented.
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Adaptation of Gamification as a Man-Machine Interface to Franchise Management System
(Institute of Electrical and Electronics Engineers Inc., 2021) ALTUNEL, YUSUF; GÜNAYDIN, BURAK; KALABALIKOĞLU, FURKAN
Current man-machine interfaces are far from fitting human expectations in understanding and transmission of noteworthy signs and hints that are natural ingredients of human communication. There are certain indicators and interaction possibilities that can be passed between the two sides but as a result of complex behavior and dynamic changing conditions of environments they can be lost, or at least might require long and complex processing. Gamification is used to enhance the interaction possibilities providing the visual representation of environmental conditions and critical indicators, as well as providing the ability to send and receive requests using suitable techniques for human such as touches, and finger moves on Unity environment. Franchise Management System is selected as a case study and adapted to maintain the interactions between franchiser and franchisee. © 2021 IEEE.
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Adaptation, Reliability, and Validation of the Turkish Version of the Bad Sobernheim Stress Questionnaire-Deformity in Patients With Adolescent Idiopathic Scoliosis
(Wolters Kluwer Health, 2023) Akçay, Burçin; Kuru Çolak, Tuǧba; APTİ, ADNAN
Background:There is a limited number of disease-specific outcome measurement scales in Turkish, which can be used for individuals with adolescent idiopathic scoliosis (AIS). The aim of this study was to translate, adapt, and evaluate the validity and reliability of the Turkish version of the Bad Sobernheim Stress Questionnaire-Deformity (TRv.BSSQD) questionnaire in Turkish patients with AIS.Objective(s):After the translation and back-translation process, the TRv.BSSQD and Scoliosis Research Society-22 questionnaires were completed in face-to-face interviews with 49 patients with AIS. The TRv.BSSQD questionnaire was readministered to the same patients 2 weeks later to assess test-retest reliability.Results:The Cronbach alpha value calculated for internal reliability was 0.806. The intraclass correlation coefficient values of the items of the TRv.BSSQD ranged from 0.809 (P < 0.001) (question 8) to 0.955 (P < 0.001) (question 7). The test-retest correlation coefficient for the item-total score was 0.960 (P < 0.001). Validity analysis showed a significantly positive correlation between the TRv.BSSQD total score and pain, self-image, and mental subgroup and the total scores of the SRS-22r scale (P < 0.05).Conclusions:This patient-reported outcome instrument, the TRv.BSSQD, showed good internal consistency, good reliability with test-retest analysis, and construct validity, suggesting that it is an appropriate assessment instrument for Turkish patients with AIS.
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Adaptive Direction-Guided Structure Tensor Total Variation
(Elsevier, 2021) Kamasak, Mustafa E.; TÜREYEN, EZGİ DEMİRCAN
Direction-guided structure tensor total variation (DSTV) is a recently proposed regularization term that aims at increasing the sensitivity of the structure tensor total variation (STV) to the changes towards a predetermined direction. Despite of the plausible results obtained on the uni-directional images, the DSTV model is not applicable to the arbitrary (multi-directional and/or partly nondirectional) images. In this study, we build a two-stage denoising framework that brings adaptivity to the DSTV based denoising. We design a DSTV-like alternative to STV, which encodes the first-order information within a local neighborhood under the guidance of spatially varying directional descriptors (i.e., orientation and the dose of anisotropy). In order to estimate those descriptors, we propose an efficient preprocessor that captures the local geometry based on the structure tensor. Through the extensive experiments, we demonstrate how beneficial the involvement of the directional information in STV is, by comparing the proposed method with the state-of-the-art analysis-based denoising models, both in terms of quality and computational efficiency.
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After the Protest: Istanbul Park Forums and People's Engagement in Political Action
(Routledge Journals, Taylor & Francis Ltd., 2022) RAMAZANOĞULLARI, HANDE
This article presents an overview of the Istanbul park forums that emerged in parallel with the Gezi events - social protest movements that took place in summer 2013. Despite the criticism that Gezi events were short-lived, impulsive, and ineffectual I argue that they have a long-lasting influence on democratic consciousness and new forms of political action. Istanbul park forums, the street and urban squares have become an important link between those who wish to transform the qualities of both democracy and the regime at large with efforts to create influence over local and national policy-making processes through engagement in political action. Drawing from the political theory of Hannah Arendt, this study assigns the capacities of 'deed and speech' to redefine 'politics'. Analyzing the politics of the park forum process through the lens and concepts of Arendt's political theory suggests an alternative way of evaluating the eventual dissolution of the Gezi events: rather than suffering from the inability to organize themselves within the conventional format of party politics, I show that the Gezi community deliberately created a new manner of engagement through political action, and thereby cast its influence as a historic landmark in the future of Turkish politics.
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Analyzing the Wastewater Treatment Facility Location/Network Design Problem via System Dynamics: Antalya, Turkey Case
(Academic Press Ltd. - Elsevier Science Ltd., 2022) DEMİREL, DUYGUN FATİH; Gönül-Sezer, Eylül Damla; Pehlivan, Seyda Alperen
Wastewater treatment facility location selection and network design issues have become attractive topics in the field of wastewater management due to increasing human population, resource scarcity, environmental concerns, and rise of necessity for sustainable solutions for future policy designs. Especially in areas where the demand for wastewater treatment increases dramatically over the years because of reasons such as high migration levels, rapid industrialization, and tourism activities, the problem turns out to be more critical and dynamic. The existing studies try to deal with the issue through mathematical modeling approaches based on optimization perspectives, which require significant computational effort. In this study, an alternative approach based on system dynamics (SD) method is proposed to examine the complex dynamic and nonlinear structure of waste-water treatment facility location selection and network design problems. The proposed SD simulation model is designed for a densely populated industrial and tourism spot, the city of Antalya, located on the Mediterranean coast of Turkey. The model is capable of determining where and when to build a new wastewater treatment facility as well as generating the generic wastewater network structure to be built for the five districts situated in the city center based on cost issues for 2015-2040 period. In addition, the impacts of demand level changes for wastewater treatment due to population variations are analyzed via several scenarios to help decision makers to develop sustainable and cost-efficient management policies. Although SD is a frequently utilized approach in the water/wastewater management arena, to the best of our knowledge, this study is the first attempt to examine the complex and dynamic nature of wastewater treatment facility location selection and network design problems through SD approach.
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Anxiolytic-Like Effects of Extremely Low Frequency Electric Field in Stressed Rats: Involvement of 5-HT2C Receptors
(Taylor & Francis Ltd., 2022) Kantar, Deniz; Acun, Alev Duygu; AFŞAR, EBRU; Yargıçoğlu, Piraye
Background Possible modulatory effects of noninvasive brain stimulation have gained interest recently. In our study, the effect of low frequency electric fields (LF-EF) on stress-induced electrophysiological, behavioral changes and the possible involvement of serotonergic 5-HT2C receptors were investigated. Materials and methods A total of eight groups including the control groups were formed by applying LF-EF with or without a 5-HT2C receptor agonist to naive or acute stress exposed rats to demonstrate the effects of LF-EF. LF-EF administration at 10 kV/m was started 30 min before acute stress application and lasted for 1 h in total. Anxiety levels and social interaction were evaluated using the elevated plus maze test and social interaction test, respectively. Auditory evoked potentials (AEP) were recorded by using ascending loudness paradigms. Loudness dependence AEP (LDAEP) was calculated by using amplitude values to analyze serotonergic transmission. Serotonin and glucocorticoid levels were measured in the frontal cortex and hippocampus. Results It was observed that the applied LF-EF reduced the anxiety behavior, and attenuated the LDAEP responses in stress and/or 5-HT2C receptor agonist applied groups. In parallel, an increase in serotonin levels and a decrease in glucocorticoid levels were observed. However, LF-EF exposure was ineffective in impaired social interaction. Conclusions Our findings show that 10 kV/m LF-EF administration may modulate the neural network and physiological responses associated with mild acute stress. 5-HT2C receptor dependent functions are thought to play a role in the anxiolytic effect of LF-EF.
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The Art of Machine Learning as Fashion Stylish for Designing Clothes
(Institute of Electrical and Electronics Engineers Inc., 2022) KEYDAL, DUYGU; OYMAK, ERENCAN; DEMİR, KADİR BATUHAN; Yılmaz, Güray; ŞAHİNGÖZ, ÖZGÜR KORAY
Over the years, designers have come to the fore with their originality and personal styles and have shaped the fashion industry with their designs. However, due to the progress of time, designers have become unable to meet the demands of all consumers. Since it takes a lot of time to produce an original design, the production process progresses slowly, and customers are uncomfortable with this situation. As in many other industries, designers are trying to solve this problem with the help of artificial intelligence, which is indispensable in the fields of commerce, art, and security. It first entered the fashion sector with drawing programs in the 1950s and has started to change the fashion sector since the 2000s. In the 1950s, artificial intelligence was used only to create a virtual drawing environment When the designer makes a mistake, he can simply erase the mistake and continue working on the design without having to start the whole design from scratch. These programs have greatly facilitated the work of designers. Designers are now able to draw their designs in a much shorter time. But even this shortened period is not enough for the whole fashion industry. Designers could still not keep up with the demands of all customers. Thanks to researchers who added different perspectives to artificial intelligence in the early 2000s with its usage not only for drawing but also for designing, Therefore, in this paper, it is aimed at producing some original designs by preserving the designer's style with the use of Aí techniques. With the proposed model, it has become able to produce ready-made designs by using features such as object detection and visual processing. The experimental results showed that Aí techniques are very successful for combining different patterns for producing an original fashion style. © 2022 IEEE.
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Assessment of Nutritional Status, Body Composition and Blood Biochemical Parameters of Patients Following Sleeve Gastrectomy: 6 Months Follow Up
(Elsevier, 2021) BATAR, NAZLI; Demir, Halime Pulat; Bayram, Hatice Merve
Background and aims: Today, Sleeve gastrectomy (SG) has recently become the most common bariatric procedure among various bariatric surgical procedures due to its advantages. The aim of this study is to investigate nutritional status, body composition and biochemical parameters following SG. Methods: This was a prospective study, the subjects were patients who underwent SG at a special obesity clinic in Istanbul, Turkey, between 01.05.2017 and 01.11.2017. The mean body mass index (BMI) of the participants was 42.15 +/- 4.84 kg/m(2) for men and 41.44 +/- 4.34 kg/m(2) for women, preoperatively. Nutritional status, some anthropometric measurements and blood sampling were taken at each visit. Data were collected and analyzed for the present study at the following periods: pre-operation (pre-op), 1 month, 3 months and 6 months after surgery. Results: A total of 47 SG patients (20 men, 27 women) were evaluated. The mean BMI was 30.23 +/- 3.56 kg/m(2) for men and 30.35 +/- 4.36 kg/m(2) for women after 6 months and the amount of excess weight loss (EWL) increased in the 3 months (p <.001). Mean energy, fiber, vitamin A, vitamin C, vitamin B-1, niacin, vitamin B-12, folate, calcium, magnesium, iron, zinc, phosphorus and iodine were above the Dietary Reference Intake (DRI) recommendations. A significant association was found between protein intake and fat free mass loss in both genders after SG at 6 months (p <.05). Conclusion: Nutrition deficiencies are common for patients after SG. Therefore, it is important to routinely monitor these patients with a professional team. (C) 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
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Assessment of Psychometric Characteristics of the Coronavirus Anxiety Scale in Patients with Preexisting Psychiatric Disorders
(Taylor & Francis, 2022) Karahamet, Elif; Angın, Ülkem; Yılmaz, Onat; DENİZ, DERYA; Konuk, Numan
This study aimed to evaluate the psychometric characteristics of the Turkish version of the CAS in a Turkish psychiatric outpatient setting. A total of 198 patients with a preexisting psychiatric disorder completed the CAS scale. The scale's validity and reliability were evaluated using convergent and concurrent validity, internal consistency, exploratory and confirmatory factor analyses, and ROC analysis. The Turkish version of CAS might help physicians assess the COVID-19 associated anxiety in patients with psychiatric comorbidities.
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Assessment of the Quality and Reliability of Information on Nutrition After Bariatric Surgery on YouTube
(Springer, 2020) BATAR, NAZLI; Yıldız, Nida; Güçlü, Duygu; SEVDİN, SEZEN; KERMEN, SEDA
Background YouTube (TM) is a platform that many people, including patients, use to access health information. Recent studies have revealed that videos on YouTube (TM) are misleading or that medical videos may not contain appropriate information. This study aimed to assess the quality and reliability of videos on nutrition after bariatric surgery. Materials and Methods The keywords "after bariatric surgery diet" and "weight loss surgery postop diet" were used, and the first 100 videos for each keyword on YouTube (TM) were analyzed by considering the source, duration, content, and the number of likes of the video. The popularity of the video was calculated using the video power index (VPI) and view rate. The educational quality of the videos was evaluated using the DISCERN score, the Journal of the American Medical Association (JAMA) score, the Global Quality Score (GQS), the usefulness score, and a novel postoperation nutrition score (PONS). Results One hundred fourteen patients were included in the study. The mean duration and number of views were 12.51 min and 87,558.46, respectively. The DISCERN score, JAMA score, GQS, and usefulness score of the physicians or dietician-based videos were significantly higher than those of the patient-based videos (p < 0.001). Positive correlations were found between the VPI and view ratio, as well as between the duration and number of likes. Additionally, the DISCERN score was significant correlated with the duration and number of likes. Significantly positive correlations were found between the usefulness score and duration, usefulness score and number of likes, and PONS and duration (p < 0.01). Conclusions Informational videos on nutrition after bariatric surgery on YouTube (TM) are of low quality. Although the videos uploaded by physicians and dieticians have higher quality, only a few are available. Additionally, patients prefer to watch low-quality videos.
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Assessment of the Risk of Pressure Ulcer During the Perioperative Period: Adaptation of the Munro Scale to Turkish
(Elsevier Science Ltd., 2021) GÜL, ASİYE; Şengül, Tuba; Yavuz, Hafize Özge
Aim of the study: This study was conducted to adapt the Munro Pressure Ulcer Risk Assessment Scale (Munro Scale) to Turkish and to test its validity and reliability. Materials and methods: In the methodological study, the data were collected using the patient identification form, the Braden Scale, and the Munro Scale. A total of 188 patients were diagnosed for the risk of preoperative and intraoperative pressure ulcer, and then re-evaluated in the recovery room and in their bed. Results: The study group consisted of 81 (43.1%) males and 107 (56.9%) females with a mean age of 51.98 ± 16.87. The Kaiser-Meyer-Olkin sampling adequacy test was 0.588 and the Bartlett's test was 430.471. The results of goodness of fit indices were not as expected value in the confirmatory factor analysis. In the exploratory factor analysis, it was determined that the factor loadings of the Munro Scale varied between 0.336 and 0.873 and explained 62% of the total variance. In the parallel-form method performed for the reliability of the scale, it was observed that there was a weak and negative correlation between the total scores of the Munro Scale and Braden Scales before the surgery and a negative and moderate correlation between the total scores after the surgery. The total Cronbach's alpha value was found to be 0.504. In the reliability analysis of the scale, interrater correlation coefficients were found to be 0.865-0.998.
Open Access
The Association of Child Abuse Experiences and Intolerance of Uncertainty in Young Adults
(Routledge, 2023) Dirican, Ayşe Hatun; Kozak, Ekin Doğa; Kavakcı, Önder; SÖNMEZ, BERNA
Objective: Drawing upon the identity disruption model, we investigated the association between child abuse experiences (emotional, physical, and sexual) and intolerance of uncertainty. We also addressed demographic differences in uncertainty intolerance in this study. Methods: Using online survey questionnaires, we collected data from a sample of 302 young adults in Turkey. The data were analyzed using confirmatory factor analysis, structural equation modeling, one-way analysis of variance, and independent samples t-test. Results: The results showed that of the three types of child abuse analyzed, only emotional abuse was significantly and positively associated with intolerance of uncertainty. In contrast, age was negatively associated with intolerance of uncertainty. Regarding demographic differences, we found that the level of intolerance of uncertainty differed based on young adults’ gender, psychiatric diagnosis, and education. Specifically, our findings indicated that intolerance of uncertainty is significantly higher in females compared to males. It is also significantly higher in young adults with a diagnosis for psychiatric disorders than those without. Moreover, intolerance of uncertainty is significantly higher in young adults who have a high school graduate degree than their undergraduate and graduate counterparts. We discussed how child abuse is associated with heightened intolerance of uncertainty in young adulthood as well as why demographic differences may exist in uncertainty intolerance. Conclusions: The present study expanded the existing research on the psychological consequences of childhood abuse experiences by linking child abuse to intolerance of uncertainty. Particularly, exposure to emotional abuse in early life can be a risk factor to cope with uncertainty in later life.
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Auxiliary Differential Diagnosis of Schizophrenia and Phases of Bipolar Disorder Based on the Blood Serum Raman Spectra
(Wiley, 2020) ILDIZ, GÜLCE ÖĞRÜÇ; Bayari, Sevgi; Aksoy, Umut M.; Yorguner, Neşe; Bulut, Hüseyin; Yılmaz, Sultan S.; Halimoğlu, Gökhan; Kabuk, Hayrunnisa Nur; YAVUZ, GİZEM; Fausto, Rui
Schizophrenia (SZ) and bipolar disorder (BP) are severe psychiatric disorders that are characterized by an extensive spectrum of symptoms and affect approximately 2% of the world population. BP exhibits three well-distinct phases, which are classified as manic and depressive episodes and euthymic phase. These disorders are of difficult differential clinical diagnosis due to the similarity of their symptoms. Diagnostic approaches for SZ and BP are based on constructed patient interviews and subjective evaluations of clinical symptoms, and there are still no molecular-based auxiliary diagnostic tools to support the clinical diagnosis. In this study, an analytical model for auxiliary differential diagnosis of SZ and BP, based on the analysis of patients' blood serum Raman spectra, is developed, which is able to account for the different BP phases and can also differentiate SZ and BP patients from healthy individuals. The model is based on a hierarchical sequence of four two-class PLS-DA steps where the Raman spectra are theX-predictor variables. It is concluded that the full 400-3,100 cm(-1)Raman spectroscopic range is a sensitive probe for the disorders, thus working as a general spectroscopic biomarker for the illnesses. The proposed methodology is reliable, fast, cheap, essentially minimal-invasive, and might be implemented easily in the clinical environment.
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Biosignal Based Emotion-Oriented Video Summarization
(Springer, 2023) DERDİYOK, ŞEYMA; AKBULUT, FATMA PATLAR
Digital video is a crucial component of multimedia that enhances presentations with accurate, engaging visual and aural data that affects several industries. The transition of video storage from analog to digital is being fueled by a variety of causes. Improved compression methods, cheaper technology, and more network needs are some of these drivers. This paper presents a novel video summarization based on physiological signals provided by emotional stimuli. Through these stimuli, 15 emotions are analyzed using physiological signals. The dataset was gathered from 15 participants who watched 61 episodes of 14 television series while wearing a wristband. We built several deep-learning models for the main purpose of recognizing emotions to summarize video. Among the established networks, the best performance has been obtained with the 1D-CNN, with 92.87% accuracy. This work has been done through a series of empirical experiments; since the frequency of the physiological signals is different, we used models with original and resampled configurations in each experiment. The comprehensive comparison result indicates that the oversampling approach gives the highest accuracy as well as the lowest computational complexity. The performance of the proposed video summarization approach was evaluated by a survey of participants, and the results showed that the summaries contained the critical moments of the video. The proposed approach may be useful and effective in physiological signal-based applications requiring emotion recognition, such as emotion-based video summarization or film genre detection. Additionally, reading such summaries facilitates comprehension of the significance of making rapid judgments regarding likes, ratings, comments, etc.
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Burnout Levels and Care Behaviours in Intensive Care Nurses: A Cross-Sectional, Multicentre Study
(Elsevier Sci Ltd., 2022) Efil, Sevda; TÜREN, SEVDA; Ayvaz, Meryem Yıldız; Bülbül, Elif; Yeni, Tuğba
Objective: To examine the relation between burnout levels and caring behaviours in intensive care nurses in Turkey, and the affecting factors. Research methodology/design: The research was conducted as a descriptive, cross-sectional and multi-centred study. Setting: In this study, an online questionnaire was applied in April and May 2021, using Google Form. A total of 460 intensive vare nurses responded to the questionnaire. Main outcome measures: Burnout was assessed with the Maslach Burnout Inventory, and care behaviours with the Caring Behaviours Inventory-24. Results: The nurses reported a high level of emotional exhaustion (73.9%) and depersonalization (52.2%), and a medium level of personal accomplishment (40%). The nurses' levels of perception of care quality were high (5.4 +/- 0.6). It was found that their highest score on the subdimensions was on knowledge and skills (5.6 +/- 0.5), and the lowest was on connectedness (5.2 +/- 0.7). There was a very weak, respectively weak correlation, between nurses' emotional exhaustion (r = -0.1), respectively depersonalization (r = -0.2), and poor care behaviours. There was a strong correlation between low personal accomplishment scores and poor care behaviours (r = 0.8). It was found that the mean scores of the nurses' exhaustion and care behaviours varied according to many descriptive characteristics, such as education, age, professional experience, the unit where they worked, communication difficulties, living conditions and whether they had chosen nursing willingly. Conclusions: It appears that the level of personal accomplishment, is the only subscale reflecting risk of burnout, that strongly correlates with care behaviour.
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Capacity Loss Analysis Using Machine Learning Regression Algorithms
(IEEE, 2022) Atay, Sergen; AYRANCI, AHMET AYTUĞ; Erkmen, Burcu
In this study, time dependent measurements of the power capacitor, which is the main equipment of a compensation unit, are given. The power capacitor is actively working in an industrial facility. Six months of the data from this capacitor were recorded and tests were carried out using Machine Learning (ML) algorithms for its remaining useful life. ML algorithms were selected from the algorithms that used for regression problems. In the study, Support Vector Machine (SVM), Linear Regression (LR) and Regression Trees (RT) algorithms were used. The rated powers of the analyzed capacitor are 50kVAR and 25kVAR from the active plant. The data set was created by running the capacitor continuously for 6 months and the capacity loss was examined with using ML algorithms. The algorithm that gives the best result in the regression analyzes is the LR algorithm. With the results obtained, it is possible to analyze how long the useful life of capacitors with the same characteristics have under the same stress.
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Cesaro Vector Lattices and Their Ideals of Finite Elements
(Springer, 2023) GÖNÜLLÜ, UĞUR; Polat, Faruk; Weber, Martin R. R.
For the Cesaro matrix C = (c(nm))(n,m?N), where c(nm) = (1)/(n), if n = m and c(nm) = 0 otherwise, the Cesaro sequence spaces ces(0), ces(p) (for 1 < p < 8) and cesoo are defined. These spaces turn out to be real vector lattices and with respect to a corresponding (naturally introduced) norm they are all Banach lattices, and so possess (or not possess) some interesting properties. In particular, the relations to their generating ideals c(0), t(p) and t(8) are investigated. Finally the ideals of all finite, totally finite and selfmajorizing elements in ces(0), ces(p) (for 1 < p <8) and ces(8) are described in detail.
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Circulating MicroRNA Expression Profiles to Identify a Potential Link Between Prostate Cancer and Obesity
(Elsevier, 2022) Arışan, Serdar; KILBAŞ, PELİN ÖZFİLİZ; RENCÜZOĞULLARI, ÖZGE; Ünsal, Narcin Palavan; Çoker-Gürkan, Ajda; Uysal-Onganer, Pınar; ARISAN, ELİF DAMLA; YERLİKAYA, PINAR OBAKAN
Effective diagnostic methods are needed to apply appropriate treatment strategies in patients with aggressive prostate cancer. From this point of view, risk factors that cause prostate cancer or its aggressiveness should be considered. Obesity is a critical risk factor for triggering prostate cancer's metastatic properties. microRNAs are used as biomarkers in diagnosing cancer and obesity depending on their tissue-specific expression patterns. This study investigates the role of obesity in the metastatic profile of prostate cancer depending on the differential expression signatures of selected miRNAs in prostate cancer and obese patients. The roles of miR-100, miR-141 and miR-145 in prostate cancer and obesity are partially known. However, their potential to become circular biomarkers in the blood is not elucidated. There is no previous data on miR-4463 and miR-653 on prostate cancer and obesity association. In this study, the blood samples were taken and obtained serum from 69 patients of 6 subgroups that consisted of one healthy group and five unhealthy groups based on their different prostate cancer or obesity levels. Five selected miRNA expression analyses (miR-100, miR-141, miR-145, miR-4463, and miR-653) were performed through total RNA isolation, which was confirmed via synthetic cel-miR-39 miRNA. Quantitative Real-Time PCR analyzed the expression levels of selected miRNAs. Data analysis was performed via normalising target miRNA expression levels with cel-miR-39. In this study, we found that the relationship between prostate cancer and obesity was investigated at the molecular level. It was suggested that target miR-100 could be a promising biomarker for non-obese and aggressive prostate cancer patients. miR-145 is a more potential biomarker than miR-141 for non-aggressive and non-obese patients. miR-4463 can be used to predict more prostate cancer patients than obese patients. Lastly, miR-653 can be a biomarker for non-aggressive prostate cancer cells.
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Cognitive Control and Flexibility to Happiness: Distress Tolerance and Difficulties in Emotion Regulation as Serial Mediators
(Springer, 2024) Satıcı, Seydi Ahmet; ÖZTÜRK, MELTEM; Okur, Sinan; Deniz, M. Engin
Happiness is a positive construct that includes individual, interrelated cognitive and emotional components and is the pursuit of human nature. In this study, serial multiple mediation analysis was performed to test the hypothetical model that addresses distress tolerance and difficulties in emotion regulation as serial mediators in the relationship between cognitive control and flexibility, and happiness. The participants were 315 Turkish individuals from 34 cities in Turkiye. The structural equation modeling revealed that both distress tolerance and difficulties in emotion regulation have a full serial mediator role in the relationships between cognitive control and flexibility, and happiness. Limitations and future research suggestions are discussed.