İKÜ Dergiler / IKU Journals
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Publication 39 spatial arrangement of the animal male germ cell genome: II. 2d-3d Simulation and visualization of spatial configuration of major chromosome 2 in Drosophila sperm(İstanbul Kültür Üniversitesi, 2007-09) Alexandrov, Igor D.; Stepanenko, Victor A.; Alexandrova, Margarita V.Data on the non-random distribution of radiationinduced inversion breakpoints were used as genetic markers for 2D and 3D modeling of the largescale architecture of the chromosome 2 in Drosophila sperm genome at the time of irradiation. During modeling, Gmax program with application of splines, the additional objects and operations as well as the methods of visualization of macromolecular biostructures were employed. A specific megarosette-loop model of spatial arrangement of chromatin fiber in the haploid sperm nucleus can account well for the experimental data.Publication AB Hukukunda Tüketici Kredileri (AB Hukukundaki Çözümlerin Işığında 4077 Sayılı Tüketicinin Korunması Hakkında Kanun ‘un Tüketici Kredilerine İlişkin Çözümlerinin Değerlendirilmesi)(İstanbul Kültür Üniversitesi, 2004) ÖZSUNAY, ERGUN; İlhan Ulusan; Cem AkbıyıkPublication Adalet ve İçişleri Alanında İşbirliği Sürecinde AB'nin Uluslararası Hukuk'daki Yeri(İstanbul Kültür Üniversitesi, 2005) Günel, Reşat Volkan; ed., Cem AkbıyıkPublication Alman Hukukunda Aynen Tazminin Önceliği İlkesinin Yumuşatıldığı Hâllere Genel Bir Bakış(İstanbul Kültür Üniversitesi, 2006) Ergüne, Mehmet Serkan; ed., Cem AkbıyıkPublication Aluminum toxicity and resistance in higher plants(İstanbul Kültür Üniversitesi, 2007-03) Vardar, Filiz; Ünal, MeralAluminum (Al) is the major element in the soil and exists as a stable complex with oxygen and silicate. When the soil pH is below 5, Al is solubilized in the soil water and absorbed by plant roots. Absorbed Al inhibits root elongation severely within hours. Al toxicity is a very important limitation to worldwide crop production, because 50% of the world’s potentially arable lands are acidic. Thus, many research has been conducted to understand the mechanism of Al toxicity and resistance which is important for stable food production in future. Al resistance can be achieved by mechanisms that facilitate Al exclusion from the root apex and/or by mechanisms that confer the ability of plants to tolerate Al in the plant symplasm. However, despite intense research efforts, there are many aspects of Al toxicity and resistance remain unclear. In this review, Al toxicity and resistance mechanisms are described with the physiological and molecular basis.Publication Aristo Düşüncesinin Roma Hukuku Üzerindeki Etkileri(İstanbul Kültür Üniversitesi, 2003) TAHİROĞLU, BÜLENT; İlhan UlusanPublication Aspect and Scope of Turkish Consumer Law(İstanbul Kültür Üniversitesi, 2005) ÖZ, MAYA TURGUT; ed., Cem AkbıyıkPublication Avrupa Birliği Roma Konvansiyonuna Göre Tüketici Sözleşmelerine Uygulanacak Hukuk(İstanbul Kültür Üniversitesi, 2004) EKŞİ, NURAY; İlhan Ulusan; Cem AkbıyıkPublication Bankanın İvazsız Olarak Müşterisi Olmayan Üçüncü Kişilere Verdiği Hatalı Banka Bilgilerinden Sorumluluğu(İstanbul Kültür Üniversitesi, 2002) ALTOP, ATİLLA; İlhan UlusanPublication Bilim, Araştırma ve Uygulamalı Hukukta Yöntem(İstanbul Kültür Üniversitesi, 2002) DÜNDAR, DURMUŞ; İlhan UlusanPublication Borçlar Kanunu Tasarısı Hükümleri Çerçevesinde Kefalete İlişkin Hükümlerin İncelenmesi(İstanbul Kültür Üniversitesi, 2005) Grassinger, Gülçin Elçin; ed., Cem AkbıyıkPublication Building Bridges: The Effects of Having an Adult Learner in a Language Class(İstanbul Kültür Üniversitesi, 2023) BATAKLAR, SİNAN; BAHADIR, AYGÜLThe purpose of the study is to analyse the effects of having an adult learner in a language class. The study was conducted in a university Preparatory Class (EPC) and was carried out with 4 EPC instructors, 5 EPC students and 1 adult learner (AL). The EPC instructors’ ages are between 36-49 and their teaching experiences are from 10 years to 24., the EPC students’ ages are between 19-21 and the adult learner is 42 and has a PhD in education. The research was designed using the convenience and purposive sampling approach. The data was collected using open-ended questions and the phenomenology technique, which is one of the qualitative research methodologies employed. The data was analysed using the qualitative content analysis approach. Based on the data analysis, noteworthy themes regarding having adult learners in a language class were discovered. The following are the themes and sub-themes: ‘challenges in having an adult learner during language learning process’ contains the sub-themes of bias to language learning, dominance of the adult learner in classroom interaction, the theme ‘benefits of having adult learner in a language class’ contains the sub-themes of motivation, raising language learning awareness, adult learner’s being a role model, knowledge transfer, career planning and the theme ‘the effects of having an adult learner in language learning process’ contains transfer of experience, strategy training, lesson planning and material design.Publication Challenges of COVID-19: Preschool Teachers’ Views and Experiences During the Quarantine(İstanbul Kültür Üniversitesi, 2022) Güneş, Gökhan; TORAN, MEHMETThe purpose of the study is to analyze the evidence gathered from the preschool teachers’ experiences during the COVID-19 pandemic quarantine. The study was carried out with 11 teachers who have professional experience ranging between 3 to 19 years from private and public preschools. The study was specified according to criterion sampling strategy under the purposeful sampling method. The data gathered via open-ended questions and the phenomenology method, one of the qualitative research designs, was used. The qualitative content analyses technique was applied for analyzing the data. It was reached remarkable themes about the preschool teachers’ pedagogical challenges during the COVID-19 pandemic based on the analysis of data. The themes and their subthemes are as follows: The theme “challenges in the distance education process” contains the sub-themes of children, teachers, and parents, the theme “views about educational policy in new normal” contains the sub-themes of technological infrastructure problems, unpreparedness, and negative attitudes, the theme “expectations for the improvement of distance education” contains the sub-themes of teacher training, effective family involvement activities, and technology-based programs.Publication Characteristics of Fabricated Soil for Landscape Rehabilitation: The Four Crop Test for Biological Activity(İstanbul Kültür Üniversitesi, 2008) Kefeli, Valentine; Leininger, Christopher; Mastalski, Shari; Kimberly, PincinFabricated soil (FS) is a mixture of substrates containing balanced amounts of carbon, nitrogen, phosphorus, potassium and mineral elements that support plant growth . In our experiments, we use FS for the rehabilitatio n of land f r om mining soil pollutants. Characteristics of fabricated soil were determined including measurements of N, P, K; other nutritive elements including Mg, Ca, S, and Fe; and micro-elements and toxic elements including Mn, Zn, A l , Ni, and Pb. Also , microbial activity of the soil was tested to determine fungal and bacterial presence. After investigating these soil characteristics, we used a four - crop test to investigate fabricated soils and related substrates for biological activity. Soil health includes a balance of mineral and organic elements and healthy microbial activity. These characteristics play the key role in the soil ' s ability to support the growth of higher plants which complete the regenerative process of soil cycling. Healthy soils provide materials for food, energy, and shelter. Healthy soils are crucial to all biological, geological, and water cycles.Publication A Comparative Study of Consumers Rights to Terminate Contract Turkish Law and Related Provisions in EU Directives(İstanbul Kültür Üniversitesi, 2004) ÖZ, MAYA TURGUT; İlhan Ulusan; Cem AkbıyıkPublication Cytological evidences of the role of Meta-topolin and Benzyladenin in barley root tips(İstanbul Kültür Üniversitesi, 2008) Huyluoğlu, Zekiye; Ünal, Meral; Palavan-Ünsal, NarçinThe responses of mitotic activity affecting root growth to benzyladenine (BA) and meta-topolin (mT) which is thought to be alternative of BA were studied with time and dose dependent experiments in Hordeum vulgare Tarm-92. The all concentrations of mT caused an induction on mitotic index. 10-5 mT was the most effective stimulator, increasing division frequency from 16 to 26 BA treatment exhibited variations; the low concentrations (10-5 M and 10-6 M) increased the mitotic index but the higher concentration (10-4 M) decreased. The values of mitotic index reflected to the elongation of roots, coordinately. BA and mT are both affected chromosomal behavior and caused abnormalities such as unoriented metaphase, chromosome bridges, 2 nucleate cells, micronuclei formation.Publication Determination of HER2/NEU gene amplification and protein overexpression ib bladder transitional cell carcinoma(İstanbul Kültür Üniversitesi, 2007-09) Atış, Gökhan; Arısan, Serdar; Ayhan, DalkılınçHER2/neu 185 kDa is a transmembrane receptor tyrosine kinase being a part of epidermal growth factor receptor family. Especially overexpression was shown in breast cancer and treatment procedures targeting this protein are in clinical use. The aim of this study is to show the overexpression of HER2/neu in bladder TCC patients by using immunohistochemical methods. 46 TCC and 15 healthy bladder tissues as a control group were used in the study. Deparafinized tumor specimens were marked by using monoclonal antihuman HER2 protein antibody and the protein was shown by using peroxidase secondary antibody. Non-staining or membrane staining less than 10% were classified as 0, while membrane staining partly more than 10% were 1, poor complete membrane staining or moderate staining more than 10% were 2 and complete membrane strongly staining were classified as 3. Classification 2 and 3 were evaluated as over staining of HER2/neu. Overexpression of HER2/Neu protein were shown in 12/46 (24.5%) of TCC specimens. Overexpression of HER2/neu were detected in 2 (12.5%) of Grade 1, 1 (16.6%) of Grade 2 and 12 (50%) of Grade 3 patients. Overexpression of HER2/Neu protein were positive in 5 (17.8%) of 28 superficial (Ta-T1) tumor specimens and 7 (38.8%) of 18 invasive (T2-T3) tumor specimens. Overexpression of HER2/neu in Grade III tumors were statistically significant when compared with Grade I and Grade II (p=0.012). Overexpression of HER2/neu detected in bladder TCC will be used in clinical setting as a treatment option targeting this protein as in the breast cancer in the future.Publication Determination of IL-10 levels in chronic pelvic pain syndrome patients(İstanbul Kültür Üniversitesi, 2008) Arısan, Serdar; Kiremit, Murat Can; Ergenekon, Erbil; Çaşkurlu, TurhanChronic pelvic pain syndrome (CPPS) is very common pathology that is characterized by pain in the perineum, pelvis, supra pubic area, or the external genitalia, with variable degrees of voiding or ejaculatory disturbance. The etiology of disorder is controversial with groups postulating infections, autoimmune, inflammatory and neuromascular mechanism. CPPS is the most commonurologic diagnosisin men younger than 50 years and the third most common urologic diagnosis in men older than 50 years after benign prostate hyperplasia and prostate cancer. Although high incidence rate, the etiology and pathophysiology of the disease are still poor.Publication Din ve Vicdan Hürriyeti ve Laik Devlet(İstanbul Kültür Üniversitesi, 2003) YAYLA, YILDIZHAN; İlhan ulusanPublication Effective Treatment in Amyotrophic Lateral Sclerosis? Invest in Each Player(İstanbul Kültür Üniversitesi, 2007-09) Chandawrkar, Akash; Özdinler, P. HandeALS (Amyotrophic lateral sclerosis) is a complex neurodegenerative disorder that affects corticospinal motor neurons in the cortex, corticobrainstem neurons and the spinal motor neurons in the spinal cord. ALS can develop both due to genetic or sporatic causes. The genetic causes of the disease are largerly unknown, but the cellular interactions between motor neurons and their environment are beginning to elicudate insights into the cellular pathogenesis of the disease. Even though cognition, memory and other brain functions are left intact in patient, the severed motor neuron circuitry leaves them paralyzed. To develop therapeutic approaches in ALS, there is a growing need to understand each and every component of the motor neuron circuitry, and their interaction in detail. In this rewiew, we will introduce cellular components of the complex neurocircuitry and discuss their possible contribution for therapeutic approaches in ALS.