Akademik Merkezler / Academic Centers

Permanent URI for this communityhttps://hdl.handle.net/11413/4999

Browse

Browsing Akademik Merkezler / Academic Centers by Author "Babiloni, Claudio"

Filter results by typing the first few letters
Now showing 1 - 3 of 3
  • No Thumbnail Available
    PublicationMetadata only
    Neurophysiological Assessment of Alzheimer's Disease Individuals by a Single Electroencephalographic Marker
    (IOS Press, Nieuwe Hemweg 6B, 1013 Bg Amsterdam, Netherlands, 2016) Lizio, Roberta; Del Percio, Claudio; Marzano, Nicola; Soricelli, Andrea; Yener, Görsev G.; Mundi, Ciro; De Rosa, Salvatore; Triggiani, Antonio Ivano; Ferri, Raffaele; Arnaldi, Dario; Nobili, Flavio Mariano; Cordone, Susanna; Lopez, Susanna; Carducci, Filippo; Santi, Giulia; Gesualdo, Loreto; Rossini, Paolo M.; Cavedo, Enrica; Mauri, Margherita; Frisoni, Giovanni B.; Babiloni, Claudio; BAŞAR, EROL; 143760; 142226
    Here we presented a single electroencephalographic (EEG) marker for a neurophysiological assessment of Alzheimer's disease (AD) patients already diagnosed by current guidelines. The ability of the EEG marker to classify 127 AD individuals and 121 matched cognitively intact normal elderly (Nold) individuals was tested. Furthermore, its relationship to AD patients' cognitive status and structural brain integrity was examined. Low-resolution brain electromagnetic tomography (LORETA) freeware estimated cortical sources of resting state eyes-closed EEG rhythms. The EEG marker was defined as the ratio between the activity of parieto-occipital cortical sources of delta (2-4 Hz) and low-frequency alpha (8-10.5 Hz) rhythms. Results showed 77.2% of sensitivity in the recognition of the AD individuals; 65% of specificity in the recognition of the Nold individuals; and 0.75 of area under the receiver-operating characteristic curve. Compared to the AD subgroup with the EEG maker within one standard deviation of the Nold mean (EEG-), the AD subgroup with EEG+ showed lower global cognitive status, as revealed by Mini-Mental State Evaluation score, and more abnormal values of white-matter and cerebrospinal fluid normalized volumes, as revealed by structural magnetic resonance imaging. We posit that cognitive and functional status being equal, AD patients with EEG+ should receive special clinical attention due to a neurophysiological "frailty". EEG+ label can be also used in clinical trials (i) to form homogeneous groups of AD patients diagnosed by current guidelines and (ii) as end-point to evaluate intervention effects.
  • Thumbnail Image
    PublicationOpen Access
    Occipital sources of resting-state alpha rhythms are related to local gray matter density in subjects with amnesic mild cognitive impairment and Alzheimer's disease
    (Elsevier Science Inc, 360 Park Ave South, New York, Ny 10010-1710 USA, 2015-02) Yener, Görsev; Emek Savaş, Derya Durusu; Babiloni, Claudio; Del Percio, Claudio; Boccardi, Marin; Lizio, Roberta; Lopez, Susanna; Carducci, Filippo; Marzano, Nicola; Soricelli, Andrea; Ferri, Raffaele; Triggiani, Antonio Ivano; Prestia, Annapaola; Salinari, Serenella; Rasser, Paul E.; Fama, Francesco; Nobili, Flavio; Gesualdo, Loreto; Mundi, Ciro; Thompson, Paul M.; Rossini, Paolo M.; Frisoni, Giovanni B.; BAŞAR, EROL; 142226
    Occipital sources of resting-state electroencephalographic (EEG) alpha rhythms are abnormal, at the group level, in patients with amnesic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Here, we evaluated the hypothesis that amplitude of these occipital sources is related to neuro-degeneration in occipital lobe as measured by magnetic resonance imaging. Resting-state eyes-closed EEG rhythms were recorded in 45 healthy elderly (Nold), 100 MCI, and 90 AD subjects. Neuro-degeneration of occipital lobe was indexed by weighted averages of gray matter density, estimated from structural MRIs. EEG rhythms of interest were alpha 1 (8-10.5 Hz) and alpha 2 (10.5-13 Hz). EEG cortical sources were estimated by low-resolution brain electromagnetic tomography. Results showed a positive correlation between occipital gray matter density and amplitude of occipital alpha 1 sources in Nold, MCI, and AD subjects as a whole group (r = 0.3, p = 0.000004, N = 235). Furthermore, there was a positive correlation between the amplitude of occipital alpha 1 sources and cognitive status as revealed by Mini Mental State Examination score across all subjects (r = 0.38, p = 0.000001, N = 235). Finally, amplitude of occipital alpha 1 sources allowed a moderate classification of individual Nold and AD subjects (sensitivity: 87.8%; specificity: 66.7%; area under the receiver operating characteristic curve: 0.81). These results suggest that the amplitude of occipital sources of resting- state alpha rhythms is related to AD neurodegeneration in occipital lobe along pathologic aging. (C) 2015 Elsevier Inc. All rights reserved.
  • No Thumbnail Available
    PublicationMetadata only
    Resting state Rolandic mu rhythms are related to activity of sympathetic component of autonomic nervous system in healthy humans
    (Elsevier Science Bv, Po Box 211, 1000 AE Amsterdam, Netherlands, 2016-05) Triggiani, Antonio Ivano; Valenzano, Anna; Del Percio, Claudio; Marzano, Nicola; Soricelli, Andrea; Petito, Annamaria; Bellomo, Antonello; Mundi, Ciro; Cibelli, Giuseppe; Babiloni, Claudio; BAŞAR, EROL; 142226
    We tested the hypothesis of a relationship between heart rate variability (HRV) and Rolandic mu rhythms in relaxed condition of resting state. Resting state eyes-closed electroencephalographic (EEG) and electrocardiographic (ECG) data were recorded (10-20 System) in 42 healthy adults. EEG rhythms of interest were high frequency alpha (10.5-13 Hz) and low-frequency beta (13-20 Hz), which are supposed to form Rolandic mu rhythms. Rolandic and occipital (control) EEG sources were estimated by LORETA software. Results showed a statistically significant (p < 0.05, corrected) negative correlation across all subjects between Rolandic cortical sources of low-frequency beta rhythms and the low-frequency band power (LF, 0.04-0.15 Hz) of tachogram spectrum as an index of HRV. The lower the amplitude of Rolandic sources of low-frequency beta rhythms (as a putative sign of activity of somatomotor cortex), the higher the LF band power of tachogram spectrum (as a putative sign of sympathetic activity). This effect was specific as there was neither a similar correlation between these EEG rhythms and high-frequency band power of tachogram spectrum (as a putative sign of parasympathetic vagal activity) neither between occipital sources of low-frequency beta rhythms (as a putative sign of activity of visual cortex) and LF band power of tachogram spectrum. These results suggest that Rolandic low frequency beta rhythms are related to sympathetic activity regulating heart rate, as a dynamic neurophysiologic oscillatory mechanism sub-serving the interaction between brain neural populations involved in somatomotor control and brain neural populations regulating ANS signals to heart for on-going homeostatic adaptations. (C) 2015 Elsevier B.V. All rights reserved.