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Serum antioxidant enzyme levels are decreased in patients with urinary calcium oxalate stones

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Date
2017-07
Author
Çakır, Ömer Onur
Culha, Mehmet Gökhan
Arısan, Serdar
Arısan, Elif Damla
Altın, Murat
Ward, Sam
Zengi, Oğuzhan
Ergenekon, Erbil
Type
Article
Language
en_US
Metadata
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Abstract
Purpose: To compare the serum antioxidant enzyme levels between patients with urinary stone disease and healthy volunteers to determine the effect of cellular oxidative stress on urinary calcium oxalate stones formation. Materials & Methods: A total of 51 patients with proven urinary calcium oxalate stones (female 35.3%, mean age: 49.3 years) and 37 healthy subjects (female 45.9%, mean age: 44.1 years) were included. The serum levels of antioxidant catalase, glutathione peroxidase, superoxide dismutase and lipid peroxidation were measured in serum samples taken from the peripheral venous circulation. Results: Mean serum catalase level of patient group was insignificantly higher than healthy subjects (7.54 mmol-H2O/mg/sec versus 6.16 mmolH2O2/mg/sec, respectively; P = .06) whereas mean superoxide dismutase level (1.56 U/ml versus 3.86 U/ml, P = .047), glutathione peroxidase level (6.70 U/ml versus 8.19 U/ml, P = .022) and lipid peroxidation level (2.35 nmol/ml versus 3.31 nmol/ml, P = .034) of patient group were significantly lower than healthy subjects. Patients with family history of urinary stone disease had significantly lower mean serum levels of catalase (P = .037), superoxide dismutase (P = .047) and glutathione peroxidase (P = .01), compared with patients without family history. Conclusion: The findings of this study provide evidence regarding the role of oxidative stress in the development of urinary calcium oxalate stones. Future clinical trials are necessary to elucidate the actual mechanisms of the calcium oxalate stone formation in the environment with increased oxidative stress.
Subject
antioxidants
calcium oxalate
oxidative stress
reactive oxygen species
urinary stone disease
Induced Oxidative Stress
Kidney-Stones
Metabolic Syndrome
Pomegranate Juice
Risk-Factors
Nephrolithiasis
Hypertension
Association
Population
Obesity
URI
https://hdl.handle.net/11413/2382
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  • Makaleler / Articles [128]

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İstanbul Kültür University

Hakkında |Politika | Kütüphane | İletişim | Send Feedback | Admin

Istanbul Kültür University, Ataköy Campus E5 Karayolu Üzeri Bakırköy 34158, İstanbul / TURKEY
Copyright © İstanbul Kültür University

Creative Commons Lisansı
IKU Institutional Repository, Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.

Designed by  UNIREPOS