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dc.contributor.authorYener, Görsev G.
dc.contributor.authorEmek Savaş, Derya Durusu
dc.contributor.authorLizio, Roberta
dc.contributor.authorÇavuşoğlu, Berrin
dc.contributor.authorCarducci, Filippo
dc.contributor.authorAdem, Emel
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorBabiloni, Claudio C.
dc.contributor.authorBaşar, Erol
dc.date.accessioned2018-07-18T11:28:01Z
dc.date.available2018-07-18T11:28:01Z
dc.date.issued2016-05
dc.identifier.issn0167-8760
dc.identifier.other1872-7697
dc.identifier.urihttps://doi.org/10.1016/j.ijpsycho.2015.02.005
dc.identifier.urihttps://hdl.handle.net/11413/2177
dc.description.abstractAmnesic mild cognitive impairment (MCI) represents a risk of developing Alzheimer's disease (AD), but not all MCI subjects progress to dementia of AD type. Magnetic resonance imaging (MRI) of cortical and hippocampal atrophy supports early diagnosis of AD in MCI subjects, while frontal event-related oscillations (EROS) at delta frequencies (<4 Hz) are appealing markers for this purpose, as they are both cost-effective and largely available. The present study tested the hypothesis that these EROs reflect cortical frontal neurodegeneration in the continuum between normal and amnesic MCI subjects. EROs and volumetric MRI data were recorded in 28 amnesic MCI and in 28 healthy elderly controls (HCs). EROs were collected during a standard visual oddball paradigm including frequent (66.6%) and rare (33.3%; targets to be mentally counted) stimuli. Peak-to-peak amplitude of delta target EROs (<4 Hz) was measured. Volume of frontal cortex was estimated from MRIs. Frontal volume was lower in MCI compared to the HC group. Furthermore, widespread delta target EROs were lower in amplitude in the former than in the latter group. Finally, there was a positive correlation between frontal volume and frontal delta target EROs in MCI and HC subjects as a whole group. These results suggest that frontal delta EROs reflect frontal neurodegeneration in the continuum between normal and amnesic MCI subjects. (C) 2015 Published by Elsevier B.V.tr_TR
dc.language.isoen_UStr_TR
dc.publisherElsevier Science Bv, Po Box 211, 1000 AE Amsterdam, Netherlandstr_TR
dc.relationInternational Journal of Psychophysiologytr_TR
dc.subjectEvent-relatedtr_TR
dc.subjectOscillationstr_TR
dc.subjectEEGtr_TR
dc.subjectMRItr_TR
dc.subjectFrontaltr_TR
dc.subjectVolumetrytr_TR
dc.subjectDeltatr_TR
dc.subjectMCItr_TR
dc.subjectAlzheimertr_TR
dc.subjectDementiatr_TR
dc.subjectAlzheimers Association Workgroupstr_TR
dc.subjectCerebral-Blood-Flowtr_TR
dc.subjectQuantitative Electroencephalographytr_TR
dc.subjectCholinesterase-Inhibitorstr_TR
dc.subjectClinical Characterizationtr_TR
dc.subjectDiagnostic Guidelinestr_TR
dc.subjectNational Institutetr_TR
dc.subjectTheta-Oscillationstr_TR
dc.subjectFrequency-Analysistr_TR
dc.subjectWavelet Transformtr_TR
dc.titleFrontal delta event-related oscillations relate to frontal volume in mild cognitive impairment and healthy controlstr_TR
dc.typeArticletr_TR
dc.contributor.authorID143760tr_TR
dc.contributor.authorID204666tr_TR
dc.contributor.authorID142226tr_TR


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