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dc.contributor.authorGürkan, Güray
dc.contributor.authorAkan, Aydın
dc.contributor.authorÖzkan Seyhan, Tülay
dc.description.abstractIn this paper we present a method for the analysis of multichannel EEG by using Generalized Partial Directed Coherence (gPDC) to extract cortical connectivity changes under anesthesia. 15 channel EEG data were recorded from female subjects undergoing general anesthesia for gynecological surgery. Multivariate Autoregressive (MAR) modeling was applied to multichannel, bipolar EEG segments of awake and anesthetized states. gPDCs were calculated using the derived MAR model and averaged through EEG alpha frequency band (8-14 Hz) and through a number of data segments. The gPDC calculation was performed for three different sets of bipolar EEG channel pairs each of which mainly represent a specific scalp area. To derive consistency levels of gPDC values, surrogate analysis is also performed. Using paired t-test for 12 patients, we extracted significant gPDC changes between. awake and anesthetized stages for each set. Analysis revealed that during transition from awake to anesthetized stage, gPDCs of central. to parietal directions were suppressed whereas gPDCs of parietal to central directions were increased. The results indicate that the proposed gPDC analysis method can be used to track the changes in brain connectivity and hence to estimate the depth of anesthesia. (C) 2013 Elsevier Inc. All rights reserved.tr_TR
dc.publisherAcademic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, Ca 92101-4495 Usatr_TR
dc.relationDigital Signal Processingtr_TR
dc.subjectMultivariate autoregressive modelingtr_TR
dc.subjectGranger causalitytr_TR
dc.subjectFrontal alpha oscillationtr_TR
dc.subjectGeneralized partial directed coherencetr_TR
dc.titleAnalysis of brain connectivity changes after propofol injection by generalized partial directed coherencetr_TR

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