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dc.contributor.authorBaşar, Erol
dc.contributor.authorYener, Görsev
dc.contributor.authorEmek Savaş, Derya Durusu
dc.contributor.authorBabiloni, Claudio
dc.contributor.authorDel Percio, Claudio
dc.contributor.authorBoccardi, Marin
dc.contributor.authorLizio, Roberta
dc.contributor.authorLopez, Susanna
dc.contributor.authorCarducci, Filippo
dc.contributor.authorMarzano, Nicola
dc.contributor.authorSoricelli, Andrea
dc.contributor.authorFerri, Raffaele
dc.contributor.authorTriggiani, Antonio Ivano
dc.contributor.authorPrestia, Annapaola
dc.contributor.authorSalinari, Serenella
dc.contributor.authorRasser, Paul E.
dc.contributor.authorFama, Francesco
dc.contributor.authorNobili, Flavio
dc.contributor.authorGesualdo, Loreto
dc.contributor.authorMundi, Ciro
dc.contributor.authorThompson, Paul M.
dc.contributor.authorRossini, Paolo M.
dc.contributor.authorFrisoni, Giovanni B.
dc.date.accessioned2018-07-16T06:58:11Z
dc.date.available2018-07-16T06:58:11Z
dc.date.issued2015-02
dc.identifier.issn0197-4580
dc.identifier.other1558-1497
dc.identifier.urihttps://doi.org/10.1016/j.neurobiolaging.2014.09.011
dc.identifier.urihttps://hdl.handle.net/11413/2093
dc.description.abstractOccipital sources of resting-state electroencephalographic (EEG) alpha rhythms are abnormal, at the group level, in patients with amnesic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Here, we evaluated the hypothesis that amplitude of these occipital sources is related to neuro-degeneration in occipital lobe as measured by magnetic resonance imaging. Resting-state eyes-closed EEG rhythms were recorded in 45 healthy elderly (Nold), 100 MCI, and 90 AD subjects. Neuro-degeneration of occipital lobe was indexed by weighted averages of gray matter density, estimated from structural MRIs. EEG rhythms of interest were alpha 1 (8-10.5 Hz) and alpha 2 (10.5-13 Hz). EEG cortical sources were estimated by low-resolution brain electromagnetic tomography. Results showed a positive correlation between occipital gray matter density and amplitude of occipital alpha 1 sources in Nold, MCI, and AD subjects as a whole group (r = 0.3, p = 0.000004, N = 235). Furthermore, there was a positive correlation between the amplitude of occipital alpha 1 sources and cognitive status as revealed by Mini Mental State Examination score across all subjects (r = 0.38, p = 0.000001, N = 235). Finally, amplitude of occipital alpha 1 sources allowed a moderate classification of individual Nold and AD subjects (sensitivity: 87.8%; specificity: 66.7%; area under the receiver operating characteristic curve: 0.81). These results suggest that the amplitude of occipital sources of resting- state alpha rhythms is related to AD neurodegeneration in occipital lobe along pathologic aging. (C) 2015 Elsevier Inc. All rights reserved.tr_TR
dc.language.isoen_UStr_TR
dc.publisherElsevier Science Inc, 360 Park Ave South, New York, Ny 10010-1710 USAtr_TR
dc.relationNeurobiology of Agingtr_TR
dc.subjectMild cognitive impairment (MCI)tr_TR
dc.subjectAlzheimer's disease (AD)tr_TR
dc.subjectElectroencephalography (EEG)tr_TR
dc.subjectMagnetic resonance imaging (MRI)tr_TR
dc.subjectGray matter density (GMD)tr_TR
dc.subjectVoxel-based morphometrytr_TR
dc.subjectTranscranial magnetic stimulationtr_TR
dc.subjectElectromagnetic tomography loretatr_TR
dc.subjectCerebral-blood-flowtr_TR
dc.subjectEeg alphatr_TR
dc.subjectQuantitative electroencephalographytr_TR
dc.subjectClinical neurophysiologytr_TR
dc.subjectInternational workshoptr_TR
dc.subjectHippocampal Atrophytr_TR
dc.subjectCortical rhythmstr_TR
dc.titleOccipital sources of resting-state alpha rhythms are related to local gray matter density in subjects with amnesic mild cognitive impairment and Alzheimer's diseasetr_TR
dc.typeArticletr_TR
dc.contributor.authorID142226tr_TR


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