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dc.contributor.authorKurt, Pınar
dc.contributor.authorEmek Savaş, Derya Durusu
dc.contributor.authorBatum, Kübra
dc.contributor.authorTurp, Bilge
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorKarşıdağ, Sibel
dc.contributor.authorYener, Görsev
dc.date.accessioned2018-07-13T08:15:18Z
dc.date.available2018-07-13T08:15:18Z
dc.date.issued2014
dc.identifier.issn0953-4180
dc.identifier.urihttps://doi.org/10.1155/2014/268967
dc.identifier.urihttps://hdl.handle.net/11413/2072
dc.description.abstractBackground. Event-related oscillations (ERO) may provide a useful tool for the identification of cognitive deficits in mild cognitive impairment (MCI) and Alzheimer's disease (AD). In the present study, we investigate peak-to-peak amplitude of auditory eventrelated delta oscillations of MCI subjects. Method. The study included twenty-two consecutive patients with MCI recruited in neurology clinic and 21 age-and education-matched normal elderly controls. A classical auditory oddball paradigm was used in the experiments. EEG was recorded from F-3, F-z, F-4, C-3, C-z, C-4, P-3, P-z, P-4, O-1, O-z, and O-2 locations. The maximum peak-to-peak amplitudes for each subject's averaged delta response (0.5-2.2Hz) weremeasured. Results. The amplitudes between groups differed significantly at the frontal and mid-centroparietal locations. ANOVA on delta responses revealed a significant effect for groups (F-(1.41) = 4.84, P = 0.033), indicating a larger delta response for healthy controls thanMCI subjects. Post hoc comparisons revealed that peak-to-peak delta response was significantly larger for healthy controls than for MCI over electrode sites F-3, F-z, F-4, C-z, C-4, and Pz. Discussion. Event-related delta frequency band seems to be the most affected oscillatory response in cognitive impairment due to AD. Therefore, it deserves to be investigated as a candidate electrophysiological biomarker in further studies.tr_TR
dc.language.isoen_UStr_TR
dc.publisherHindawi Publishing Corporation, 410 Park Avenue, 15Th Floor, #287 Pmb, New York, Ny 10022 Usatr_TR
dc.relationBehavioural Neurologytr_TR
dc.subjectAlzheimers-Diseasetr_TR
dc.subjectPotentialstr_TR
dc.subjectThetatr_TR
dc.subjectDementiatr_TR
dc.subjectScaletr_TR
dc.subjectElectroencephalographytr_TR
dc.subjectConversiontr_TR
dc.subjectDiagnosistr_TR
dc.subjectAttentiontr_TR
dc.subjectNetworkstr_TR
dc.titlePatients with Mild Cognitive Impairment Display Reduced Auditory Event-Related Delta Oscillatory Responsestr_TR
dc.typeArticletr_TR
dc.contributor.authorID24351tr_TR
dc.contributor.authorID227002tr_TR
dc.contributor.authorID142090tr_TR
dc.contributor.authorID204666tr_TR
dc.contributor.authorID9297tr_TR
dc.contributor.authorID143760tr_TR


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