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dc.contributor.authorÇoker Gürkan, Ajda
dc.contributor.authorGüngör, Barış
dc.contributor.authorEkmekçi, Ahmet
dc.contributor.authorArman, Ahmet
dc.contributor.authorÖzcan, Kazım S.
dc.contributor.authorÜçer, Ekrem
dc.contributor.authorÇalık, Nazmi
dc.contributor.authorYılmaz, Hale
dc.contributor.authorTezel, Tuna
dc.contributor.authorBolca, Osman
dc.description.abstractBackgroundSystemic inflammation is accepted as one of the pathophysiological mechanisms of atrial fibrillation (AF). The role of inflammation has been shown previously. Interleukin (IL) system is the main modulator of the inflammatory responses and genetic polymorphisms of IL-1 cluster genes are associated with increased risk for inflammatory diseases. ObjectivesTo investigate the association between polymorphisms of IL-1 cluster genes and lone AF. Subjects and MethodsDNA samples were collected from 70 proven lone AF patients and 70 healthy subjects. Genomic DNA was typed for the variable number of the tandem repeat (VNTR) IL-1 receptor antagonist (RN) gene polymorphism, IL-1B -511 C > T(rs16944) promoter polymorphism, and +3953 C > T(rs1143634) polymorphism in exon 5 by polymerase chain reaction. ResultsIn lone AF group the frequency of IL-1RN2/2 and IL-1RN1/2 genotypes were higher than in the control group (7.2% vs 4.3% and 48.5% vs 22.8%, respectively; (2) = 14.1; P = 0.028). The frequency of allele 2 was significantly higher in the lone AF group (32.1% vs 15.7%; (2) = 10.7; P = 0.005). Allele and genotype distribution of IL-1B -511 C > T and +3953 C > T polymorphisms were not statistically different between the groups. C-reactive protein (CRP) levels were higher in lone AF patients compared to the control group (median = 1.25, interquartile range [IQR] = 0.85 vs median = 1.08, IQR 0.46 mg/L, respectively; P = 0.02). In multivariate regression analysis, presence of allele 2 of IL-1 VNTR polymorphism and elevated plasma high-sensitive-CRP levels were the independent predictors of lone AF. ConclusionPresence of allele 2 of VNTR polymorphism of IL-1RN gene may cause increased risk for lone AF probably due to the inadequate limitation of inflammatory reactions.tr_TR
dc.publisherWiley-Blackwell, 111 River St, Hoboken 07030-5774, Nj USAtr_TR
dc.relationPace-Pacing And Clinical Electrophysiologytr_TR
dc.subjectLone Atrial Fibrillationtr_TR
dc.subjectInterleukin Polymorphismtr_TR
dc.subjectC-Reactive Proteintr_TR
dc.subjectOf-Function Mutationtr_TR
dc.subjectReceptor Antagonisttr_TR
dc.subjectYalnız Atriyal Fibrilasyontr_TR
dc.subjectInterlökin Polimorfizmtr_TR
dc.subjectC-Reaktif Proteintr_TR
dc.subjectKoroner Arter Hastalığıtr_TR
dc.subjectFonksiyon Değiştirme Mutasyonutr_TR
dc.subjectReseptör Antagonistitr_TR
dc.subjectMiyokardiyal Enfarktüstr_TR
dc.subjectIskemik İnmetr_TR
dc.titleAssessment of Interleukin-1 Gene Cluster Polymorphisms in Lone Atrial Fibrillation: New Insight into the Role of Inflammation in Atrial Fibrillationtr_TR

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