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dc.contributor.authorBaşar, Erol
dc.contributor.authorYener, Görsev
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorNecioğlu Örken, Dilek
dc.contributor.authorForta, H.
dc.date.accessioned2017-10-20T07:49:51Z
dc.date.available2017-10-20T07:49:51Z
dc.date.issued2012
dc.identifier.issn0953-4180
dc.identifier.urihttp://hdl.handle.net/11413/1715
dc.description.abstractBackground: Visual delta event-related (ERO) and evoked oscillations (EO) of Alzheimer patients (AD) are different than healthy. In the present study, the analysis is extented to include auditory ERO and EO in AD. The rationale is to reveal whether the auditory ERO delta responses are also reduced, and whether this is a general phenomenon in Alzheimer patients upon applying stimuli with cognitive load. Methods.: Thirty-four mild AD subjects 117 de-novo and 17 medicated (cholinergic)l and seventeen healthy controls were included. Auditory oddball paradigm and sensory auditory stimuli were applied to the subjects. Oscillatory responses were analyzed by measuring maximum amplitudes in delta frequency range (0.5-3.5 Hz). Results: Auditory delta ERO (0.5-3.5 Hz) responses of healthy controls were higher than either de-novo AD or medicated AD group, without a difference between two AD subgroups. Furthermore, the auditory EO after presentation of tone bursts yielded no group difference. Conclusion: Our findings imply that delta ERO is highly unstable in AD patients in comparison to age-matched healthy controls only during the cognitive paradigm. Our results favor the hypothesis that neural delta networks are activated during cognitive tasks and that the reduced delta response is a general phenomenon in AD, due to cognitive impairment.tr_TR
dc.language.isoentr_TR
dc.publisherIos Press, Nieuwe Hemweg 6B, 1013 Bg Amsterdam, Netherlandstr_TR
dc.relationBehavioural Neurologytr_TR
dc.subjectalzheimertr_TR
dc.subjectP300tr_TR
dc.subjectoscillationstr_TR
dc.subjectauditorytr_TR
dc.subjectdeltatr_TR
dc.subjectcholinergictr_TR
dc.subjectmild cognitive impairmenttr_TR
dc.subjectworking-memory tasktr_TR
dc.subjectbrain oscillationstr_TR
dc.subjecttheta-oscillationstr_TR
dc.subjectEEGtr_TR
dc.subjectalphatr_TR
dc.subjectrhythmstr_TR
dc.subjectelectroencephalographytr_TR
dc.subjectschizophreniatr_TR
dc.subjectsalınımlartr_TR
dc.subjectişitseltr_TR
dc.subjectdeltatr_TR
dc.subjectkolinerjiktr_TR
dc.subjecthafif kognitif bozukluktr_TR
dc.subjectçalışma-bellek görevtr_TR
dc.subjectbeyin salınımlarıtr_TR
dc.subjectteta-salınımlarıtr_TR
dc.subjectalfatr_TR
dc.subjectritimlertr_TR
dc.subjectelektroensefalografitr_TR
dc.subjectşizofrenitr_TR
dc.titleAuditory Delta Event-related Oscillatory Responses are Decreased in Alzheimer's Diseasetr_TR
dc.typeArticletr_TR
dc.contributor.authorID142226tr_TR
dc.contributor.authorID143760tr_TR
dc.contributor.authorID204666tr_TR


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