Now showing items 31-40 of 91
Orlistat is a fatty acid synthase (FASN) inhibitor caused the modulation of AMPK and lipogenesis signaling axis in PC3 prostate cancer cells but not in PNT1A prostate epithelial cells
(Wiley, 111 River St, Hoboken 07030-5774, NJ USA, 2017-09)
CDK inhibitors-induced SSAT expression requires NF kappa B and PPAR gamma in MCF-7 breast cancer cells
(TUBİTAK Scientific & Technical Research Council Turkey, Ataturk Bulvarı No 221, Kavaklıdere, Ankara, 00000, Turkey, 2015)
The cyclin-dependent kinase (CDK) inhibitors purvalanol and roscovitine are therapeutic agents that control cell proliferation through regulating cell-cycle machinery. They also affect polyamine (PA) metabolism, which is ...
Cyclin-dependent kinase inhibitors, roscovitine and purvalanol, induce apoptosis and autophagy related to unfolded protein response in HeLa cervical cancer cells
(Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands, 2018-10)
Roscovitine (Rosc) and purvalanol (Pur) are competitive inhibitors of cyclin-dependent kinases (CDKs) by targeting their ATP-binding pockets. Both drugs are shown to be effective to decrease cell viability and dysregulate ...
Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-kappa B signaling and polyamine metabolism in breast cancer cells
Curcumin is assumed to be a plant-derived therapeutic drug that triggers apoptotic cell death in vitro and in vivo by affecting different molecular targets such as NF-kappa B. Phase I/II trial of curcumin alone or with ...
Biological responses of ultrafine grained pure titanium and their sand blasted surfaces
(Elsevier Science Bv, Po Box 211, 1000 Ae Amsterdam, Netherlands, 2018-10-01)
The use of materials as implants has become vital for determining optimal product design to enhance the needs of usage and longevity in body. Ultrafine grained pure titanium offers advanced mechanical properties for medical ...
Multiple Sclerosis: Association with the Interleukin-1 Gene Family Polymorphisms in the Turkish Population
(Informa Healthcare, Telephone House, 69-77 Paul Street, London Ec2A 4Lq, England, 2013-10)
Background: Multiple Sclerosis (MS) is a neurodegenerative disease. It involves inflammation and demyelination. Since cytokines play an important role in the development of MS, genes encoding cytokines such as the Interleukin ...
Polyamine Depletion Enhances The Roscovitine-Induced Apoptosis Through The Activation Of Mitochondria In HCT116 Colon Carcinoma Cells
(Springer, 233 Spring St, New York, Ny 10013 Usa, 2012-02)
Small molecule inhibitors of cyclin-dependent kinases (CDKs) show high therapeutic potential in various cancer types which are characterized by the accumulation of transformed cells due to impaired apoptotic machinery. ...
Percutaneous Valve Replacement: Where Do We Stand? Where Are We Going?
(Drunpp-Sarajevo, Bolnicka Bb, Sarajevo, 71000, Bosnia & Herceg, 2010)
Background: Percutaneous valve replacement is a relatively new treatment modality that is rapidly growing in application. Aim&Objectives: Percutaneous treatment of valve diseases has been an alternative to open surgery ...
Inhibition Of Ornithine Decarboxylase Alters The Roscovitine-Induced Mitochondrial-Mediated Apoptosis In MCF-7 Breast Cancer Cells
(Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2012-05)
Polyamines (PAs) are small aliphatic amines that play a major role in multicellular functions. The PA levels are controlled by ornithine decarboxylase (ODC), the rate limiting enzyme of PA biosynthesis. alpha-difluoromet ...
Lack Of Association Between IL-6 Gene Polymorphisms And Rheumatoid Arthritis In Turkish Population
(Springer Heidelberg, Tiergartenstrasse 17, D-69121 Heidelberg, Germany, 2012-07)
Inflammatory cytokines play an important role in the pathogenesis of rheumatoid arthritis (RA). One of candidate genes is interleukin-6 (IL-6), and single-nucleotide polymorphisms in the promoter region of IL-6 were found ...