Now showing items 1-4 of 4
Polyamine Depletion Enhances The Roscovitine-Induced Apoptosis Through The Activation Of Mitochondria In HCT116 Colon Carcinoma Cells
(Springer, 233 Spring St, New York, Ny 10013 Usa, 2012-02)
Small molecule inhibitors of cyclin-dependent kinases (CDKs) show high therapeutic potential in various cancer types which are characterized by the accumulation of transformed cells due to impaired apoptotic machinery. ...
Inhibition of Polyamine Oxidase Prevented Cyclin-Dependent Kinase Inhibitor-Induced Apoptosis in HCT 116 Colon Carcinoma Cells
(Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands, 2013-12)
Roscovitine and purvalanol are novel cyclin-dependent kinase (CDK) inhibitors that prevent cell proliferation and induce apoptotic cell death in various cancer cell lines. Although a number of studies have demonstrated the ...
Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation
(Oxford University Press, 2009-09-01)
Increased expression of antiapoptotic Bcl-2 proteins confers therapeutic resistance in various cancer types. Targeting Bcl-2 proteins by small molecules or activating alternative pathways to bypass Bcl-2-mediated protection ...
Inhibition of extracellular signal-regulated kinase potentiates the apoptotic and antimetastatic effects of cyclin-dependent kinase inhibitors on metastatic DU145 and PC3 prostate cancer cells
(Wiley Online Library, 2018-10-15)
Purvalanol and roscovitine are specific cyclin‐dependent kinase (CDK) inhibitors,which have antiproliferative and apoptotic effects on various types of cancer.Although, the apoptotic accomplishment of purvalanol and ...