Now showing items 1-4 of 4
Epibrassinolide-induced apoptosis regardless of p53 expression via activating polyamine catabolic machinery, a common target for androgen sensitive and insensitive prostate cancer cells
(Wiley-Blackwell, 111 River St, Hoboken 07030-5774, Nj Usa, 2014-12)
BACKGROUNDEpibrassinolide (EBR), is a member of the brassinosteroids (BR), has been shown as an apoptotic inducer in different cancer cell lines. We previously showed that EBR induced apoptosis by activating polyamine ...
Inhibition Of Ornithine Decarboxylase Alters The Roscovitine-Induced Mitochondrial-Mediated Apoptosis In MCF-7 Breast Cancer Cells
(Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2012-05)
Polyamines (PAs) are small aliphatic amines that play a major role in multicellular functions. The PA levels are controlled by ornithine decarboxylase (ODC), the rate limiting enzyme of PA biosynthesis. alpha-difluoromet ...
Downregulation of c-Myc mediated ODC expression after purvalanol treatment is under control of upstream MAPK signaling axis in MCF-7 breast cancer cells
(Tubitak Scientific & Technical Research Council Turkey, Ataturk Bulvarı No 221, Kavaklıdere, Ankara, 00000, Turkey, 2014)
Roscovitine and purvalanol are specific cyclin-dependent kinase (CDK) inhibitors, which induce apoptosis by triggering cell cycle arrest in various cancer cells such as colon, prostate, and breast cancer cells. Although ...
Silencing Of The Polyamine Catabolic Key Enzyme SSAT Prevents CDK Inhibitor-Induced Apoptosis In Caco-2 Colon Cancer Cells
(Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2012-04)
Roscovitine and purvalanol are purine derivative cyclin-dependent kinase (CDK) inhibitors that induce apoptosis in various types of cancer cells. However, their impact on the apoptotic cell death mechanism requires further ...