Now showing items 1-3 of 3
Polyamine Depletion Enhances The Roscovitine-Induced Apoptosis Through The Activation Of Mitochondria In HCT116 Colon Carcinoma Cells
(Springer, 233 Spring St, New York, Ny 10013 Usa, 2012-02)
Small molecule inhibitors of cyclin-dependent kinases (CDKs) show high therapeutic potential in various cancer types which are characterized by the accumulation of transformed cells due to impaired apoptotic machinery. ...
Inhibition Of Ornithine Decarboxylase Alters The Roscovitine-Induced Mitochondrial-Mediated Apoptosis In MCF-7 Breast Cancer Cells
(Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2012-05)
Polyamines (PAs) are small aliphatic amines that play a major role in multicellular functions. The PA levels are controlled by ornithine decarboxylase (ODC), the rate limiting enzyme of PA biosynthesis. alpha-difluoromet ...
Silencing Of The Polyamine Catabolic Key Enzyme SSAT Prevents CDK Inhibitor-Induced Apoptosis In Caco-2 Colon Cancer Cells
(Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2012-04)
Roscovitine and purvalanol are purine derivative cyclin-dependent kinase (CDK) inhibitors that induce apoptosis in various types of cancer cells. However, their impact on the apoptotic cell death mechanism requires further ...