Now showing items 1-2 of 2
Silencing Of The Polyamine Catabolic Key Enzyme SSAT Prevents CDK Inhibitor-Induced Apoptosis In Caco-2 Colon Cancer Cells
(Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2012-04)
Roscovitine and purvalanol are purine derivative cyclin-dependent kinase (CDK) inhibitors that induce apoptosis in various types of cancer cells. However, their impact on the apoptotic cell death mechanism requires further ...
Polyamine Depletion Enhances The Roscovitine-Induced Apoptosis Through The Activation Of Mitochondria In HCT116 Colon Carcinoma Cells
(Springer, 233 Spring St, New York, Ny 10013 Usa, 2012-02)
Small molecule inhibitors of cyclin-dependent kinases (CDKs) show high therapeutic potential in various cancer types which are characterized by the accumulation of transformed cells due to impaired apoptotic machinery. ...