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Lack of functional p53 renders DENSpm-induced autophagy and apoptosis in time dependent manner in colon cancer cells
(Springer Wien, Sachsenplatz 4-6, Po Box 89, A-1201 Wien, Austria, 2015-01)
Polyamines (PAs), such as putrescine, spermidine and spermine, are alkyl-amines that are essential for cell growth, proliferation, differentiation and cancer progression in eukaryotic cells. A designed PA analogue; DENSpm, ...
EBR promotes p53 independent apoptosis in colon carcinoma cell lines
(Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ USA, 2015-07)
Serotonin altered receptor tyrosine signalling pathway differently in MCF-7 and MDA-MB-231 breast cancer cells
(Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2017)
The potential role of polyamine metabolism in different growth hormone mutations (E33G, N47D, T-24A, A13S, W-7X, IVS1+GAAA, IVS1+83C-1, F166Del) on Epithelial mesenchymal transition (EMT) in HEK293
(Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ USA, 2016-09)
The role of polyamine metabolism in curcumin induced apoptosis via reactive oxygene species (ROS) generation in growth hormone (GH) overexpressed T47D breast cancer cells
(Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ USA, 2016-09)
Investigation of Roscovitine (Cyc202)-Induced Apoptosis Related With Polyaminemetabolism in Mcf-7 Human Breast Cancer Cell Line
(John Wiley & Sons Inc, 111 River St, Hoboken, Nj 07030 USA, 2009-03)
Polyamines modulate the roscovitine-induced cell death switch decision autophagy vs. apoptosis in MCF-7 and MDA-MB-231 breast cancer cells
(Spandidos Publ Ltd, Pob 18179, Athens, 116 10, Greece, 2015-06)
Current clinical strategies against breast cancer mainly involve the use of anti-hormonal agents to decrease estrogen production; however, development of resistance is a major problem. The resistance phenotype depends on ...
Orlistat as a fatty acid synthase inhibitor blocks cell survival mechanism via activating PTEN, which controls PI3K/AKT/MAPK axis in PC3 prostate cancer cells
(Elsevier Science Bv, Po Box 211, 1000 AE Amsterdam, Netherlands, 2017-08-30)
Orlistat is a fatty acid synthase (FASN) inhibitor caused the modulation of AMPK and lipogenesis signaling axis in PC3 prostate cancer cells but not in PNT1A prostate epithelial cells
(Wiley, 111 River St, Hoboken 07030-5774, NJ USA, 2017-09)
Cyclin-dependent kinase inhibitors, roscovitine and purvalanol, induce apoptosis and autophagy related to unfolded protein response in HeLa cervical cancer cells
(Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands, 2018-10)
Roscovitine (Rosc) and purvalanol (Pur) are competitive inhibitors of cyclin-dependent kinases (CDKs) by targeting their ATP-binding pockets. Both drugs are shown to be effective to decrease cell viability and dysregulate ...