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Inhibition of extracellular signal-regulated kinase potentiates the apoptotic and antimetastatic effects of cyclin-dependent kinase inhibitors on metastatic DU145 and PC3 prostate cancer cells
(Wiley Online Library, 2018-10-15)
Purvalanol and roscovitine are specific cyclin‐dependent kinase (CDK) inhibitors,which have antiproliferative and apoptotic effects on various types of cancer.Although, the apoptotic accomplishment of purvalanol and ...
Bag-1L mediated chemoresistance mechanism through preventing downregulation of Mcl-1 and c-Raf by heat shock proteins in HeLa cells
Background: Cisplatin, a DNA damaging agent, induces apoptosis through increasing DNA fragmentation. However, identification of intrinsic resistance molecules against Cisplatin is vital to estimate the success of ...