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Bag-1 Silencing Enhanced Chemotherapeutic Drug-induced Apoptosis in MCF-7 Breast Cancer Cells Affecting PI3K/Akt/mTOR and MAPK Signaling Pathways
(2019-01-19)The multifunctional anti-apoptotic Bag-1 protein has important roles in apoptosis, proteasome-mediated degradation, transcriptional regulation, and intracellular signaling. Bag-1 promotes cell survival and proliferation, ... -
Curcumin Prevented Human Autocrine Growth Hormone (GH) Signaling Mediated NF-κB Activation and miR-183-96-182 Cluster Stimulated Epithelial Mesenchymal Transition in T47D Breast Cancer Cells
(2019-02)Autocrine growth hormone (GH) signaling is a promoting factor for breast cancer via triggering abnormal cell growth, proliferation, and metastasis, drug resistance. Curcumin (diferuloylmethane), a polyphenol derived from ... -
Anti-metastatic effect of ranolazine in an in vivo rat model of prostate cancer, and expression of voltage-gated sodium channel protein in human prostate
(2019-03-20)Background Voltage-gated Na+ channels (VGSCs) are functionally upregulated in rat and human prostate cancer (PCa) where channel activity promotes cellular invasiveness in vitro and metastasis in vivo. Ranolazine is a ... -
Effect of polyamines on leaf rolling during drought stress in Ctenanthe setosa (Rosc.) Eichler
(2002)The effects of the three main polyamines, putrescine, spermine, and spermidine, on the degree of leaf rolling in Ctenanthe setosa were investigated. In addition, the interactions between the amounts of endogenic polyamines ... -
Manganase superoxide dismutase polymorphism in chronic pelvic pain syndrome patients
(2006)Chronic pelvic pain syndrome (CPPS) is a common and serious health problem affecting the quality of life in men. In this study, we aim to investigate the manganase superoxide dismutase (MnSOD) polymorphism at nucleotide ... -
Lack of evidence for the association of ornithine decarboxylase (+316 G>A), spermidine/spermine acetyl transferase (‑1415 T>C) gene polymorphisms with calcium oxalate stone disease
(2013)Urolithiasis is a complex and multifactorial disorder characterized by the presence of stones in the urinary tract. Urea cycle is an important process involved in disease progression. L‑ornithine is a key amino acid in the ... -
Bag-1L mediated chemoresistance mechanism through preventing downregulation of Mcl-1 and c-Raf by heat shock proteins in HeLa cells
(2014-11)Background: Cisplatin, a DNA damaging agent, induces apoptosis through increasing DNA fragmentation. However, identification of intrinsic resistance molecules against Cisplatin is vital to estimate the success of ... -
Purvalanol induces endoplasmic reticulum stress mediated apoptosis and autophagy by purvalanol in HCT 116 colon cancer cells
(2015-06)Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. Various ...
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