Show simple item record

dc.contributor.authorYener, Görsev
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorBaşar, Erol
dc.date.accessioned2016-04-26T08:23:12Z
dc.date.available2016-04-26T08:23:12Z
dc.date.issued2008-06
dc.identifier.issn1351-5101
dc.identifier.urihttp://hdl.handle.net/11413/1174
dc.description.abstractBackground and purpose: Alzheimer type of dementia (AD) is the most common neuropsychiatric morbidity in elderly individuals. Event-related oscillations (ERO) provide an useful tool for detecting subtle abnormalities of cognitive processes with high temporal resolution. Methods: In the present report, event-related oscillations of patients with AD were analyzed by using a visual oddball paradigm. A total of 22 mild probable AD subjects according to NINCDS-ADRDA criteria and 20 age-, gender-, and education-matched healthy control subjects were compared. AD group consisted from 11 untreated patients and 11 patients treated with cholinesterase inhibitor. Oscillatory responses were recorded from 13 scalp electrodes. Results: Significant differences in delta frequency range were seen between the groups by using repeated measures of ANOVA analysis [F(9.120) = 2.228; P = 0.022]. Post-hoc analyses using Wilcoxon test showed that at mid- and left central regions, (Cz, C3) peak amplitudes of delta responses of healthy subjects were significantly higher than either group. Also cholinesterase inhibitors did not have effect on delta oscillatory responses. Conclusions: Our findings imply that the delta oscillatory responses at central locations are highly instable in mild probable AD patients regardless of treatment when compared to the healthy aged controls. This study supports the importance of oscillatory event-related potentials for investigating AD brain dynamics.tr_TR
dc.language.isoen_UStr_TR
dc.publisherWILEY-BLACKWELL, COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USAtr_TR
dc.relationEUROPEAN JOURNAL OF NEUROLOGYtr_TR
dc.subjectalzheimertr_TR
dc.subjectdeltatr_TR
dc.subjectdementiatr_TR
dc.subjectevent-related potentialstr_TR
dc.subjectoscillationstr_TR
dc.subjectP300tr_TR
dc.subjectvisualtr_TR
dc.subjectmild cognitive impairmenttr_TR
dc.subjectworking-memory tasktr_TR
dc.subjecttheta-oscillationstr_TR
dc.subjectbrain oscillationstr_TR
dc.subjectcat hippocampustr_TR
dc.subjectdiseasetr_TR
dc.subjecteegtr_TR
dc.subjectpotentialstr_TR
dc.subjectrhythmstr_TR
dc.subjectdementiaworking-memory tasktr_TR
dc.subjectbunaklıktr_TR
dc.subjectolaya ilişkin potansiyellertr_TR
dc.subjectsalınımlartr_TR
dc.subjectgörseltr_TR
dc.subjecthafif kognitif bozukluktr_TR
dc.subjectİşçi bellek görevitr_TR
dc.subjectteta-titreşimlertr_TR
dc.subjectbeyin salınımlartr_TR
dc.subjectkedi hipokampustr_TR
dc.subjecthastalıktr_TR
dc.subjectpotansiyellertr_TR
dc.subjectritimlertr_TR
dc.subjectbunama işçi bellek görevitr_TR
dc.titleEvent-related delta oscillatory responses of Alzheimer patientstr_TR
dc.typeArticletr_TR
dc.contributor.authorIDTR142226tr_TR
dc.contributor.authorIDTR143760tr_TR
dc.contributor.authorIDTR204666tr_TR


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record