Now showing items 31-40 of 96
Diclofenac induced apoptosis via altering PI3K/Akt/MAPK signaling axis in HCT 116 more efficiently compared to SW480 colon cancer cells
(Springer Link, 2018-12)
Diclofenac is a preferential cyclooxygenase 2 inhibitor (COX-2) and member of non-steroidal anti-inflammatory drugs (NSAIDs). Inflammation is one of the main reason of poor prognosis of colon cancer cases; thereby NSAIDs ...
Endoplasmic reticulum stress is activated after epibrassinolide treatment leading autophagy in wild type and Atg5/ mouse embryonic fibroblasts: a survival mechanism in nonmalignant cells.
Autophagy is a process of cellular selfdegradation during which macromolecules, damaged/aged organelles and proteins are delivered to the lysosome by engulfment within doublemembrane vesicles. The accumulation of ...
Autocrine Growth Hormone-Triggered Curcumin Resistance Abolished by NF-κB Signaling Pathway Dependent on Inflammatory Cytokines and Active Polyamine Catabolic Machinery in MCF-7, MDA-MB-453 and MDA-MB-231 Breast Cancer Cells
Autocrine Growth Hormone (GH) induces cell growth, proliferation metastasis in breast cancer. Curcumin is a promising therapeutic agent in cancer through affecting different molecular targets. Our aim was to demonstrate ...
Celastrol Modulates Lipid Synthesis via PI3K/Akt/mTOR Signaling Axis to finalize Cell Death Response in Prostate Cancer Cells
FASN is key enzyme during lipid biogenesis is associated with prostate cancer. In this study, we aim to investigate the potential role of celastrol, root extracts of Tripterygium wilfordii on modulation of lipid ...
Roscovitine treatment inhibited cell proliferation and induced apoptosis via modulating activity of Stat3 and Foxo1 under control of Akt in LNCaP prostate cancer cells
Cyclin dependent kinases (CDKs) are known activators of nuclear hormone receptors; such as androgen receptor (AR) via modulating several cell survival signaling routes. However, novel CDK inhibitors might also prevent cell ...
Orlistat is a fatty acid synthase (FASN) inhibitor caused the modulation of AMPK and lipogenesis signaling axis in PC3 prostate cancer cells but not in PNT1A prostate epithelial cells
Prostate cancer is one the leading cancer type after lung cancer among male. Obesity is one of the known risk factor for developing highly aggressive and metastatic prostate cancer, which is an obstacle in cancer therapy. ...